Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)
NCT06362252 · View on ClinicalTrials.gov ↗
Study Summary
This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) atezolizumab with or without carboplatin in participants with extensive stage-small cell lung cancer (ES-SCLC) in the first-line (1L) setting.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Atezolizumab
- DRUG Ifinatamab deruxtecan
Study Locations (20)
New York
- New York University Cancer Center - Laura and Isaac Perlmutter Cancer Center At Nyu Langone — Mineola
- NYU Langone Hospital - Long Island — Mineola
- Memorial Sloan Kettering Cancer Center — New York
- Columbia University Hervert Irving Comprehensive Cancer Center — New York
- Montefiore Medical Center — New York
Florida
- Mayo Clinic-Jacksonville — Jacksonville
- Advent Health Orlando — Orlando
- Moffitt Cancer Center — Tampa
California
- David Geffen School of Medicine — Los Angeles
- Hoag Memorial Hospital Presbyterian — Newport Beach
Minnesota
- Regents of the University of Minnesota — Minneapolis
- Mayo Clinic — Rochester
New Jersey
- Astera Cancer Care — East Brunswick
- John Theurer Cancer Center At Hackensack Umc — Hackensack
Alabama
- University of Alabama -Birmingham — Birmingham
Arizona
- Mayo Clinic Arizona — Phoenix
Illinois
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 123 participants |
| Start Date | 2024-07-22 |
| Est. Completion | 2026-12-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06362252
The ClinicalTrials.gov registry entry for NCT06362252 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 123 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Daiichi Sankyo, which has 157 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Extensive Stage-small Cell Lung Cancer appearing as the primary indexed condition, and to 3 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06362252 reports 20 study locations spanning 11 distinct geographic areas — top geographies include New York, Florida, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06362252 about?
NCT06362252 is a clinical study titled "A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)". This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) atezolizumab with or without carboplatin in participants with extensive stage-small cell lung cancer (ES-SCLC) in the first-line (1L) setting.
What is the current status of trial NCT06362252?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 123 participants. The study started on 2024-07-22. Estimated completion is 2026-12-30.
What conditions does trial NCT06362252 study?
This clinical trial studies the following conditions: Extensive Stage-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06362252?
The interventions under investigation include: Carboplatin (DRUG), Atezolizumab (DRUG), Ifinatamab deruxtecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06362252?
This trial is sponsored by Daiichi Sankyo, which has 157 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06362252 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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