Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

NCT06819007 · View on ClinicalTrials.gov ↗

Study Summary

This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Trastuzumab Deruxtecan

Study Locations (20)

Florida

  • Broward Health Medical Center — Fort Lauderdale
  • Jupiter Medical Center — Jupiter
  • Mount Sinai Medical Center — Miami Beach
  • AdventHealth Cancer Institute — Orlando
  • Woman's Care FL — St. Petersburg

Michigan

  • Trinity Health St. Joseph Mercy Ann Arbor — Ann Arbor
  • Corewell Health — Grand Rapids

New York

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone — New York
  • Icahn School of Medicine at Mount Sinai — New York

California

  • Scripps Clinic — La Jolla

Georgia

  • Nancy N. & J.C Lewis Cancer & Research Pavillion- St. Josephs/ Candler Health System — Savannah

Indiana

  • Indiana University — Indianapolis

Louisiana

  • Trials365 LLC — Shreveport

Maryland

  • Greater Baltimore Medical Center — Towson

Trial Details

FieldValue
Enrollment Target 582 participants
Start Date 2025-03-19
Est. Completion 2032-01-31
Phase Phase 3

Sponsor

Daiichi Sankyo

157 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06819007

The ClinicalTrials.gov registry entry for NCT06819007 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 582 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Daiichi Sankyo, which has 157 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ovarian Cancer appearing as the primary indexed condition, and to 2 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06819007 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, Michigan, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06819007 about?

NCT06819007 is a clinical study titled "Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)". This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-...

What is the current status of trial NCT06819007?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 582 participants. The study started on 2025-03-19. Estimated completion is 2032-01-31.

What conditions does trial NCT06819007 study?

This clinical trial studies the following conditions: Ovarian Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06819007?

The interventions under investigation include: Bevacizumab (DRUG), Trastuzumab Deruxtecan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06819007?

This trial is sponsored by Daiichi Sankyo, which has 157 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06819007 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Indiana, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial