Brigham and Women's Hospital

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Brigham and Women's Hospital sits in the top decile of US sponsors by registered trial count (#35 of 15,742 sponsors by registered trial count).

937 total trials 145 currently recruiting 608 completed early-phase tilt top decile by trial count

Brigham and Women's Hospital: 937 sponsored US clinical trials, 145 recruiting.

Brigham and Women's Hospital sponsors 937 registered US clinical trials on ClinicalTrials.gov, 145 of them currently recruiting, and 608 completed. 124 of these trials are in Phase 3-4 (later-stage) and 197 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Type 2 Diabetes, with 13 trials.

Top-decile sponsor footprint

Brigham and Women's Hospital ranks in the top decile of sponsors by registered trial count (#35 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 64/100

608 of 677 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (89.8%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

937 total, page 16 of 19

COMPLETED Phase 4

The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis

NCT01383954

TERMINATED NA

Collar Immobilization Following a Posterior Cervical Laminectomy and Fusion

NCT01383876

COMPLETED

Prediction of Findings From the Ongoing CAROLINA Trial Using Healthcare Database Analyses

NCT03648424

COMPLETED Phase 3

Optimizing Protein Intake in Older Americans With Mobility Limitations

NCT01275365

COMPLETED Phase 2

Sorbent Therapy of the Cutaneous Porphyrias

NCT01422915

COMPLETED

Use and Effectiveness of a Model Integrative Care Clinic in an Academic Hospital: Study 1-Survey

NCT01353560

COMPLETED Phase 3

A Risk Based Approach to Improving Chronic Kidney Disease Management

NCT01203813

COMPLETED Phase 1

Oral OKT3 for the Treatment of Active Ulcerative Colitis

NCT01287195

COMPLETED Phase 4

Oxytocin And Uterotonic Agent Use For Cesarean Delivery

NCT01549223

COMPLETED

Prediction of Outcomes Following Total Knee Replacement

NCT01370421

COMPLETED Phase 3

Blacks and Exacerbations on Long Acting Beta Agonists (LABA) vs. Tiotropium (BELT)

NCT01290874

COMPLETED NA

Multi-Center Medication Reconciliation Quality Improvement Study

NCT01337063

COMPLETED NA

Demonstration of Near Zero Antibiotic Prescribing for Acute Bronchitis

NCT01240174

COMPLETED NA

Sleep Apnea Intervention for Cardiovascular Disease Reduction

NCT01261390

COMPLETED Phase 3

Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function

NCT01320722

COMPLETED Phase 4

Integrated Dual Exercise and Lexiscan Positron Emission Tomography: IDEALPET

NCT01109992

COMPLETED NA

Hypoglycemia and the Mineralocorticoid Receptor

NCT01394627

COMPLETED Phase 4

Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis

NCT01207453

COMPLETED NA

Development of a Sign-Out Tool to Improve Handoffs in Care

NCT01398761

COMPLETED Phase 4

Barbed Suture vs Smooth Suture for Vaginal Cuff Closure

NCT01262573

COMPLETED

Quantification of Human Adipogenesis

NCT01257997

COMPLETED NA

Effects of Intravenous Lidocaine on Endometriosis Pain

NCT01968694

COMPLETED Phase 2

Effects of cKit Inhibition by Imatinib in Patients With Severe Refractory Asthma (KIA)

NCT01097694

COMPLETED NA

Integrating Patient Generated Family Health History From Varied Electronic Health Record (EHR) Entry Portals

NCT00977847

COMPLETED NA

Light Sensitization Study

NCT01327040

COMPLETED NA

An Automatic Notification System for Test Results Finalized After Discharge

NCT01153451

COMPLETED Phase 4

Clinical Trial of a Silver Eluting Dressing System

NCT01229358

COMPLETED Phase 3

Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation

NCT00970489

COMPLETED NA

Dietary Fat and High-Density Lipoprotein (HDL) Metabolism-Effect of Carbohydrate and Fat Intake

NCT01399632

COMPLETED NA

Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain

NCT01351805

COMPLETED NA

VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL

NCT01696435

COMPLETED NA

Positive Airway Pressure for the Treatment of Asthma

NCT01154699

TERMINATED NA

Novel Pathways to Manage Inflammation and Atherosclerosis in Dialysis Patients: Role of Nicotinic Acid

NCT01159054

COMPLETED Phase 3

Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis

NCT01132118

TERMINATED NA

Assessment of Renin Inhibition on Insulin Sensitivity, Diastolic Function and Aortic Compliance

NCT01252238

COMPLETED NA

Improving Glycemic Control on GMS: A Quality Improvement Study

NCT00271700

COMPLETED

Altered Brain GABA and Glutamate in Restless Legs Syndrome

NCT01109537

TERMINATED Phase 4

Effect of Short Term Aliskiren Treatment in Kidney Transplant Patients

NCT01437943

COMPLETED NA

Effect of Eplerenone on Postprandial Inflammatory Response in Healthy Adults

NCT01786551

COMPLETED NA

Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in Obesity

NCT01068418

COMPLETED Phase 2

Heart Biomarker Evaluation in Apnea Treatment

NCT01086800

COMPLETED NA

Risk Evaluation and Education for Alzheimer's Disease (REVEAL) IV

NCT01434667

COMPLETED Phase 4

Effect of Estradiol+Drospirenone Versus Estradiol+MPA on Endothelial Function

NCT01109979

COMPLETED NA

Human Circadian Sensitivity to Very Short Light Pulses

NCT01330992

COMPLETED Phase 2

Diabetes Prevention in Women With a Recent History of Gestational Diabetes Mellitus (GDM)

NCT01158131

COMPLETED NA

Face Transplantation for Treatment of Severe Facial Deformity

NCT01281267

COMPLETED NA

A Brief Intervention to Improve Cost-effective Resource Use Among Medicine Housestaff

NCT01303263

COMPLETED NA

Does Emotional Support Decrease In Vitro Fertilization Stress?

NCT01406028

COMPLETED NA

Melatonin Treatment for Induced Transient Insomnia

NCT00950885

COMPLETED Phase 3

Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART)

NCT00920621

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Phase Distribution

PhaseTrial count
Phase 1 90
Phase 2 107
Phase 3 47
Phase 4 77

What is open in the Brigham and Women's Hospital pipeline

145 recruiting of 937 indexed (15% open); 608 completed (65%).

Phase mix: 124 late (III/IV) vs 197 early (I/II) (early-phase heavy).

Top condition: Type 2 Diabetes (13 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Brigham and Women's Hospital: open-pipeline peers nationwide

Peers matched on 937 registered trials and 15% open enrollment, not the therapeutic-area sidebar.

Brigham and Women's Hospital sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,500 5%10%15%20% Total trials Recruiting share Brigham and Women's HospitalColumbia UniversityHoffmann-La RocheUniversity of MinnesotaUniversity of California, Los AngelesIncyte CorporationNorthwestern UniversityNationwide Children's HospitalUniversity of Michigan Rogel Cancer Center
Brigham and Women's Hospital sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Brigham and Women's Hospital sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 937 trials (± recruiting share)

Sponsors near 15% open enrollment (± trial volume)

What to do with this Brigham and Women's Hospital page

937 registered trials is a research-attention snapshot, not an endorsement of Brigham and Women's Hospital or any single study.

  • 145 of Brigham and Women's Hospital's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Type 2 Diabetes is the condition Brigham and Women's Hospital studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Type 2 Diabetes trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Brigham and Women's Hospital pipeline card: 937 registered trials from official public datasets.Report a data error.