Brigham and Women's Hospital

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Brigham and Women's Hospital sits in the top decile of US sponsors by registered trial count (#35 of 15,742 sponsors by registered trial count).

937 total trials 145 currently recruiting 608 completed early-phase tilt top decile by trial count

Brigham and Women's Hospital: 937 sponsored US clinical trials, 145 recruiting.

Brigham and Women's Hospital sponsors 937 registered US clinical trials on ClinicalTrials.gov, 145 of them currently recruiting, and 608 completed. 124 of these trials are in Phase 3-4 (later-stage) and 197 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Type 2 Diabetes, with 13 trials.

Top-decile sponsor footprint

Brigham and Women's Hospital ranks in the top decile of sponsors by registered trial count (#35 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 64/100

608 of 677 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (89.8%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

937 total, page 12 of 19

COMPLETED Phase 2

Phase ll Study of Pirfenidone in Patients With RAILD (TRAIL1)

NCT02808871

COMPLETED

PREG-MS: New England MS Pregnancy Registry

NCT03368157

COMPLETED Phase 1

Fecal Microbiota Transplantation for the Treatment of Obesity

NCT02741518

COMPLETED Phase 1

Establishing 18F-PBR06 PET Imaging as a Viable Pharmacodynamic Endpoint in MSA

NCT03033680

COMPLETED Phase 2

Dexamethasone Solution for the Treatment of Oral Lichen Planus

NCT02850601

COMPLETED Phase 1

Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain

NCT02824276

COMPLETED NA

Conducting Perioperative Code Status and Goals of Care Discussions: A Bi-Institutional Study to Develop a Novel, Evidence-Based Curriculum for Anesthesiology Trainees

NCT04045886

COMPLETED NA

Interactive Digital Health Tools to Improve Patient Safety in Acute Care

NCT03116074

COMPLETED NA

A Novel Mobile App & Population Management System to Manage Rheumatoid Arthritis Flares

NCT02822521

COMPLETED NA

Risk Evaluation and Education for Alzheimer's Disease - the Study of Communicating Amyloid Neuroimaging (REVEAL-SCAN)

NCT02959489

COMPLETED NA

Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1

NCT02642640

COMPLETED NA

Influence of Sleep Regularity on Circadian Rhythms, Learning, Performance, and Mood

NCT02839070

COMPLETED

Lipids, Inflammation, and CV Risk in RA

NCT02714881

COMPLETED NA

Electronic Medication Adherence Reporting and Feedback During Care Transitions

NCT03475030

COMPLETED NA

Comparison of US-Guided Paravertebral and Proximal Intercostal Nerve Blocks

NCT02911168

COMPLETED NA

Bioboosti Device for Insomnia Treatment

NCT02924116

COMPLETED NA

Balance After Baby Intervention for Women With Recent Gestational Diabetes

NCT02744300

COMPLETED Phase 1

Atomoxetine and Oxybutynin in Obstructive Sleep Apnea

NCT02908529

COMPLETED NA

Hospitalization at Home: The Acute Care Home Hospital Program for Adults

NCT02864420

TERMINATED Phase 4

Pulmonary Artery Pressure Reduction With ENTresto (Sacubitril/Valsartan)

NCT02788656

COMPLETED Phase 4

INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure

NCT02787044

COMPLETED Phase 1

Effect of Background Noise on Sleep Quality

NCT02945254

COMPLETED NA

Integrating Online Weight Management With Primary Care Support

NCT02656693

COMPLETED

Role of Inflammatory Mediators in AERD

NCT02824523

COMPLETED NA

Targeted Adherence Intervention to Reach Glycemic Control With Insulin Therapy for Patients With Diabetes

NCT02846779

COMPLETED Phase 4

Treatments Against RA and Effect on FDG-PET/CT

NCT02374021

COMPLETED Phase 2

COLA: A Pilot Clinical Trial of COX-2 Inhibition in LAM and TSC

NCT02484664

COMPLETED

CMR Features in Patients With Suspected Myocarditis

NCT03470571

COMPLETED Early Phase 1

Assess Efficacy of of Oral Treprostinil in Patients With Symptomatic Primary or Secondary Raynaud's Phenomenon

NCT02583789

COMPLETED NA

Electronic Alerts for Stroke Prevention in Patients With Atrial Fibrillation or Atrial Flutter

NCT02339493

COMPLETED Early Phase 1

Personalized Immunotherapeutic for Antibiotic-resistant Infection

NCT02508584

COMPLETED NA

Quantifying and Developing Countermeasures for the Effect of Fatigue-Related Stressors on Automation Use and Trust During Robotic Supervisory Control

NCT02755493

COMPLETED NA

Improving Quality by Maintaining Accurate Problems in the EHR

NCT02596087

COMPLETED NA

Coronary Flow Reserve to Assess Cardiovascular Inflammation (CIRT-CFR)

NCT02786134

COMPLETED Phase 1

Effect of Statin Use on Aldosterone Secretion

NCT02871687

COMPLETED NA

Effects of Light and Exercise on Human Circadian Rhythms and Performance

NCT02747719

COMPLETED NA

Medication Adherence Improvement Support App For Engagement - Blood Pressure

NCT02727543

COMPLETED

Perioperative Outcomes of Common Methods of Minimally Invasive Contained Tissue Extraction

NCT02496130

TERMINATED Phase 2

Tocilizumab Augmentation in Treatment-Refractory Major Depressive Disorder

NCT02660528

COMPLETED Phase 1

Intravenous Indocyanine Green for Localization of Intra-thoracic Lesions

NCT03097627

COMPLETED Phase 1

Fecal Microbiota Transplantation for the Treatment of Primary Sclerosing Cholangitis.

NCT02424175

COMPLETED

Preoperative Cognitive Screening in Older Surgical Patients Utility for Predicting Morbidity

NCT02598050

COMPLETED NA

Impact of Antioxidant Juice Intake on Brain Injury and Placental Pathology in Infants With Intrauterine Growth Restriction (IUGR)

NCT04394910

COMPLETED Phase 2

Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults

NCT02656160

COMPLETED Phase 2

Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism

NCT02525796

COMPLETED Phase 1

The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production

NCT02871648

TERMINATED Phase 2

Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population.

NCT02631148

COMPLETED NA

Pilot Study of Health Information Technology for Chronic Kidney Disease Management

NCT02990897

COMPLETED NA

Implementation of the NPMS Obstetric Hemorrhage Bundle at a Tertiary Center: Utilization of the Delphi Method

NCT03018119

COMPLETED Phase 1

Clinical Trial to Evaluate the Safety and Analgesic Efficacy of VVZ-149 in Lumbar Radiculopathy (Sciatica)

NCT02644421

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Phase Distribution

PhaseTrial count
Phase 1 90
Phase 2 107
Phase 3 47
Phase 4 77

What is open in the Brigham and Women's Hospital pipeline

145 recruiting of 937 indexed (15% open); 608 completed (65%).

Phase mix: 124 late (III/IV) vs 197 early (I/II) (early-phase heavy).

Top condition: Type 2 Diabetes (13 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Brigham and Women's Hospital: open-pipeline peers nationwide

Peers matched on 937 registered trials and 15% open enrollment, not the therapeutic-area sidebar.

Brigham and Women's Hospital sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,500 5%10%15%20% Total trials Recruiting share Brigham and Women's HospitalColumbia UniversityHoffmann-La RocheUniversity of MinnesotaUniversity of California, Los AngelesIncyte CorporationNorthwestern UniversityNationwide Children's HospitalUniversity of Michigan Rogel Cancer Center
Brigham and Women's Hospital sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Brigham and Women's Hospital sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 937 trials (± recruiting share)

Sponsors near 15% open enrollment (± trial volume)

What to do with this Brigham and Women's Hospital page

937 registered trials is a research-attention snapshot, not an endorsement of Brigham and Women's Hospital or any single study.

  • 145 of Brigham and Women's Hospital's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Type 2 Diabetes is the condition Brigham and Women's Hospital studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Type 2 Diabetes trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Brigham and Women's Hospital pipeline card: 937 registered trials from official public datasets.Report a data error.