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Type 2 Diabetes Mellitus clinical trials
15 of 123 indexed Type 2 Diabetes Mellitus trials are currently recruiting.
123 US clinical trials · 15 currently recruiting
Type 2 Diabetes Mellitus is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 51 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 11 of these trials.
The research picture
Type 2 Diabetes Mellitus has 123 registered US clinical trials, 15 of them open to new participants right now, about 12% of the total.
- 15
- recruiting participants now
- 12%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 11
- top sponsor: AstraZeneca
Active & Recent Trials
123 total, page 2 of 3
REAL HEALTH-Diabetes: Reach Ahead for Lifestyle and Health-Diabetes
Massachusetts General Hospital
NCT02320253
A 12-week Study To Evaluate PF-06291874 Once a Day in Adults With T2DM Inadequately Controlled On Metformin
Pfizer
NCT02554877
A Study to Evaluate Safety and Efficacy of TTP054 for 12 Weeks in Subjects With Type 2 Diabetes
vTv Therapeutics
NCT01665352
The Efficacy and Treatment Adherence With an Integrated Program on HbA1c Scores in Patients With Type 2 Diabetes
KRJG Services
NCT01626053
Integrating Depression Services Into DM Management
University of Pennsylvania
NCT01098253
University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)
University of Florida
NCT00994682
Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)
Merck Sharp & Dohme
NCT04029480
Ginkgo Biloba Extract and the Insulin Resistance Syndrome
National Center for Complementary and Integrative Health (NCCIH)
NCT00032474
A Study of LGD-6972 in Patients With Type 2 Diabetes Mellitus
Ligand Pharmaceuticals
NCT02851849
Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00212290
Study of KD026 in Combination With Metformin in Subjects With Type 2 Diabetes Mellitus
Response Pharmaceuticals
NCT02434744
Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes
Massachusetts General Hospital
NCT03818581
Physical Activity and Participation
VA Office of Research and Development
NCT02268916
Long Term Free Living Study With Modified Foods and Type 2 Diabetics
Johns Hopkins Bloomberg School of Public Health
NCT00198913
4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes
Pfizer
NCT03538743
Exercise Training and Glucose Metabolism in Aging
US Department of Veterans Affairs
NCT00701051
Safety and Efficacy Study of PN2034 in Type 2 Diabetes Patients on Concomitant Rosiglitazone and Metformin (or Avandamet)
Wellstat Therapeutics
NCT00110851
Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes
Joslin Diabetes Center
NCT01073020
A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A
Hanmi Pharmaceutical Company Limited
NCT01724814
A Phase 1 Single/Multiple Dose Study Of PF-06293620 To Assess Safety, Tolerability And Pharmacokinetics In Subjects With Type 2 Diabetes Mellitus
Pfizer
NCT02211261
A Study of Renal Autologous Cell Therapy (REACT) in Type 2 Diabetics With Chronic Kidney Disease
Prokidney
NCT02836574
Dance Dance Revolution (DDR) in Type 2 Diabetes
Charles Drew University of Medicine and Science
NCT00851019
Adding Liraglutide to High Dose Insulin: Breaking the Cycle
Ildiko Lingvay
NCT01505673
A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release
Midwest Center for Metabolic and Cardiovascular Research
NCT05287906
A Bioequivalence Study Testing Two Formulations of Sotagliflozin in Healthy Male and Female Subjects Under Fasted Conditions
Sanofi
NCT03776227
A Study to Examine the Pharmacokinetics, Tolerability, Safety and Efficacy of Exenatide Once Weekly Suspension
AstraZeneca
NCT00894322
Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus
Brigham and Women's Hospital
NCT00762671
Financial Incentives Telephone Education and Skills Trial in African Americans With Diabetes (FITEST)
State University of New York at Buffalo
NCT02722499
Effect of Diabetes Mellitus on Cholesterol Metabolism
Medical College of Wisconsin
NCT00879710
Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Baylor Research Institute
NCT02251431
Grocery Prescription Program for Medicaid Adults With Hypertension or Type 2 Diabetes
Alison Gustafson
NCT06033664
TAK-648 Multiple-Rising Dose Study in Healthy Japanese Participants and Non-Japanese Participants With Type 2 Diabetes Mellitus
Takeda
NCT02430870
Yo Puedo! Diabetes Self-Management Education + mHealth in Mexico City
Yale University
NCT03159299
Diabetes Prevention and Control in the Workplace: A Pilot Study
State University of New York - Upstate Medical University
NCT00739336
Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1
The University of Texas Health Science Center at San Antonio
NCT03560323
Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients
St. Paul Heart Clinic
NCT00123643
A Study to Compare the Safety and Drug Levels in Blood When Using Various Forms of GSK189075 Given to Healthy Subjects
GlaxoSmithKline
NCT00559884
Effects on Colesevelam HC1 (WelChol®) on Insulin Sensitivity in Subjects With Type 2 Diabetes Mellitus
Daiichi Sankyo
NCT00361153
Study to Assess Safety and Pharmacokinetics of Double-Blind S-707106 Alone and in Combination With Open-Label Metformin in Patients With Type 2 Diabetes Mellitus
Shionogi
NCT01154348
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
Pacira Pharmaceuticals
NCT02762370
Continuous Glucose Monitoring (CGM) in Subjects With Type 2 Diabetes
Rocky Mountain Diabetes and Osteoporosis Center
NCT01341067
Effect of Exenatide on 24-Hour Blood Glucose Profile Compared With Placebo in Patients With Type 2 Diabetes
AstraZeneca
NCT00241423
A Phase I Study to Assess the Pharmacodynamics of Oral AR-C165395XX in Subjects With Type 2 Diabetes Mellitus (T2DM)
AstraZeneca
NCT02367066
Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects
AstraZeneca
NCT00904176
A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
GlaxoSmithKline
NCT00501462
Antioxidant Effects of Pomegranate Juice Versus Placebo in Adults With Type 2 Diabetes Mellitus
University of Colorado, Denver
NCT00668954
Does Pioglitazone Increase the Production of 15-EPI-Lipoxin A4?
Baylor College of Medicine
NCT01040819
Single Cohort, 2-Period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine 500 mg
Gilead Sciences
NCT01546558
Determinants of Diabetes Remission After Gastric Bypass Surgery
Blandine Laferrere
NCT02287285
A Clinical Study to Investigate the Effect of SAR425899 on Energy Expenditure in Obese Subjects
Sanofi
NCT03376802
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 23 |
| Phase 3 | 16 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 2 Diabetes Mellitus Trial Landscape
123 indexed Type 2 Diabetes Mellitus studies · 15 recruiting (12%).
Phase mix: 26 late (III/IV) vs 51 early (I/II).
Top sponsor: AstraZeneca (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 2 Diabetes Mellitus?
PlainTrial tracks 123 US clinical trials for Type 2 Diabetes Mellitus, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 2 Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.