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ClinicalTrials.gov 15 recruiting now official registry

Type 2 Diabetes Mellitus clinical trials

15 of 123 indexed Type 2 Diabetes Mellitus trials are currently recruiting.

123 US clinical trials · 15 currently recruiting

Type 2 Diabetes Mellitus is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 51 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 11 of these trials.

The research picture

Type 2 Diabetes Mellitus has 123 registered US clinical trials, 15 of them open to new participants right now, about 12% of the total.

15
recruiting participants now
12%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
11
top sponsor: AstraZeneca
Phase 128Phase 223Phase 316Phase 410

Active & Recent Trials

123 total, page 2 of 3

COMPLETED NA 211 participants

REAL HEALTH-Diabetes: Reach Ahead for Lifestyle and Health-Diabetes

Massachusetts General Hospital

NCT02320253

COMPLETED Phase 2 206 participants

A 12-week Study To Evaluate PF-06291874 Once a Day in Adults With T2DM Inadequately Controlled On Metformin

Pfizer

NCT02554877

COMPLETED Phase 2 186 participants

A Study to Evaluate Safety and Efficacy of TTP054 for 12 Weeks in Subjects With Type 2 Diabetes

vTv Therapeutics

NCT01665352

COMPLETED NA 182 participants

The Efficacy and Treatment Adherence With an Integrated Program on HbA1c Scores in Patients With Type 2 Diabetes

KRJG Services

NCT01626053

COMPLETED NA 182 participants

Integrating Depression Services Into DM Management

University of Pennsylvania

NCT01098253

COMPLETED Phase 4 176 participants

University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)

University of Florida

NCT00994682

COMPLETED Phase 3 166 participants

Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)

Merck Sharp & Dohme

NCT04029480

COMPLETED Phase 1 150 participants

Ginkgo Biloba Extract and the Insulin Resistance Syndrome

National Center for Complementary and Integrative Health (NCCIH)

NCT00032474

COMPLETED Phase 2 148 participants

A Study of LGD-6972 in Patients With Type 2 Diabetes Mellitus

Ligand Pharmaceuticals

NCT02851849

COMPLETED Phase 4 140 participants

Insulin Resistance and Central Nervous System (CNS) Function in Type 2 Diabetes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00212290

COMPLETED Phase 2 121 participants

Study of KD026 in Combination With Metformin in Subjects With Type 2 Diabetes Mellitus

Response Pharmaceuticals

NCT02434744

COMPLETED Phase 4 108 participants

Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes

Massachusetts General Hospital

NCT03818581

COMPLETED NA 104 participants

Physical Activity and Participation

VA Office of Research and Development

NCT02268916

COMPLETED NA 100 participants

Long Term Free Living Study With Modified Foods and Type 2 Diabetics

Johns Hopkins Bloomberg School of Public Health

NCT00198913

COMPLETED Phase 1 98 participants

4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes

Pfizer

NCT03538743

COMPLETED NA 90 participants

Exercise Training and Glucose Metabolism in Aging

US Department of Veterans Affairs

NCT00701051

COMPLETED Phase 2 90 participants

Safety and Efficacy Study of PN2034 in Type 2 Diabetes Patients on Concomitant Rosiglitazone and Metformin (or Avandamet)

Wellstat Therapeutics

NCT00110851

COMPLETED NA 88 participants

Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes

Joslin Diabetes Center

NCT01073020

COMPLETED Phase 1 86 participants

A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM12460A

Hanmi Pharmaceutical Company Limited

NCT01724814

COMPLETED Phase 1 84 participants

A Phase 1 Single/Multiple Dose Study Of PF-06293620 To Assess Safety, Tolerability And Pharmacokinetics In Subjects With Type 2 Diabetes Mellitus

Pfizer

NCT02211261

COMPLETED Phase 2 83 participants

A Study of Renal Autologous Cell Therapy (REACT) in Type 2 Diabetics With Chronic Kidney Disease

Prokidney

NCT02836574

COMPLETED NA 76 participants

Dance Dance Revolution (DDR) in Type 2 Diabetes

Charles Drew University of Medicine and Science

NCT00851019

COMPLETED Phase 4 71 participants

Adding Liraglutide to High Dose Insulin: Breaking the Cycle

Ildiko Lingvay

NCT01505673

COMPLETED NA 69 participants

A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release

Midwest Center for Metabolic and Cardiovascular Research

NCT05287906

COMPLETED Phase 1 66 participants

A Bioequivalence Study Testing Two Formulations of Sotagliflozin in Healthy Male and Female Subjects Under Fasted Conditions

Sanofi

NCT03776227

COMPLETED Phase 1 65 participants

A Study to Examine the Pharmacokinetics, Tolerability, Safety and Efficacy of Exenatide Once Weekly Suspension

AstraZeneca

NCT00894322

COMPLETED Phase 2 60 participants

Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus

Brigham and Women's Hospital

NCT00762671

COMPLETED NA 60 participants

Financial Incentives Telephone Education and Skills Trial in African Americans With Diabetes (FITEST)

State University of New York at Buffalo

NCT02722499

COMPLETED NA 57 participants

Effect of Diabetes Mellitus on Cholesterol Metabolism

Medical College of Wisconsin

NCT00879710

COMPLETED Phase 3 57 participants

Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome

Baylor Research Institute

NCT02251431

COMPLETED NA 50 participants

Grocery Prescription Program for Medicaid Adults With Hypertension or Type 2 Diabetes

Alison Gustafson

NCT06033664

COMPLETED Phase 1 48 participants

TAK-648 Multiple-Rising Dose Study in Healthy Japanese Participants and Non-Japanese Participants With Type 2 Diabetes Mellitus

Takeda

NCT02430870

COMPLETED NA 47 participants

Yo Puedo! Diabetes Self-Management Education + mHealth in Mexico City

Yale University

NCT03159299

COMPLETED NA 45 participants

Diabetes Prevention and Control in the Workplace: A Pilot Study

State University of New York - Upstate Medical University

NCT00739336

COMPLETED Phase 1 41 participants

Ketones, Muscle Metabolism, and SGLT2 Inhibitors - Protocol 1

The University of Texas Health Science Center at San Antonio

NCT03560323

COMPLETED Phase 4 36 participants

Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients

St. Paul Heart Clinic

NCT00123643

COMPLETED Phase 1 36 participants

A Study to Compare the Safety and Drug Levels in Blood When Using Various Forms of GSK189075 Given to Healthy Subjects

GlaxoSmithKline

NCT00559884

COMPLETED Phase 2 35 participants

Effects on Colesevelam HC1 (WelChol®) on Insulin Sensitivity in Subjects With Type 2 Diabetes Mellitus

Daiichi Sankyo

NCT00361153

COMPLETED Phase 1 34 participants

Study to Assess Safety and Pharmacokinetics of Double-Blind S-707106 Alone and in Combination With Open-Label Metformin in Patients With Type 2 Diabetes Mellitus

Shionogi

NCT01154348

COMPLETED Phase 2 33 participants

Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes

Pacira Pharmaceuticals

NCT02762370

COMPLETED 30 participants

Continuous Glucose Monitoring (CGM) in Subjects With Type 2 Diabetes

Rocky Mountain Diabetes and Osteoporosis Center

NCT01341067

COMPLETED Phase 2 30 participants

Effect of Exenatide on 24-Hour Blood Glucose Profile Compared With Placebo in Patients With Type 2 Diabetes

AstraZeneca

NCT00241423

COMPLETED Phase 1 30 participants

A Phase I Study to Assess the Pharmacodynamics of Oral AR-C165395XX in Subjects With Type 2 Diabetes Mellitus (T2DM)

AstraZeneca

NCT02367066

COMPLETED Phase 1 30 participants

Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects

AstraZeneca

NCT00904176

COMPLETED Phase 1 29 participants

A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function

GlaxoSmithKline

NCT00501462

COMPLETED NA 26 participants

Antioxidant Effects of Pomegranate Juice Versus Placebo in Adults With Type 2 Diabetes Mellitus

University of Colorado, Denver

NCT00668954

COMPLETED Phase 4 25 participants

Does Pioglitazone Increase the Production of 15-EPI-Lipoxin A4?

Baylor College of Medicine

NCT01040819

COMPLETED Phase 1 25 participants

Single Cohort, 2-Period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine 500 mg

Gilead Sciences

NCT01546558

COMPLETED Early Phase 1 25 participants

Determinants of Diabetes Remission After Gastric Bypass Surgery

Blandine Laferrere

NCT02287285

COMPLETED Phase 1 24 participants

A Clinical Study to Investigate the Effect of SAR425899 on Energy Expenditure in Obese Subjects

Sanofi

NCT03376802

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Phase Distribution

PhaseTrial count
Phase 1 28
Phase 2 23
Phase 3 16
Phase 4 10

Top Sponsors

AstraZeneca 11 trials
Bayer 4 trials
Daiichi Sankyo 4 trials
Sanofi 4 trials
Gilead Sciences 3 trials
Pfizer 3 trials
Yale University 3 trials
GlaxoSmithKline 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 2 Diabetes Mellitus Trial Landscape

123 indexed Type 2 Diabetes Mellitus studies · 15 recruiting (12%).

Phase mix: 26 late (III/IV) vs 51 early (I/II).

Top sponsor: AstraZeneca (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 2 Diabetes Mellitus?

PlainTrial tracks 123 US clinical trials for Type 2 Diabetes Mellitus, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 2 Diabetes Mellitus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.