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ClinicalTrials.gov 15 recruiting now official registry

Type 2 Diabetes Mellitus clinical trials

15 of 123 indexed Type 2 Diabetes Mellitus trials are currently recruiting.

123 US clinical trials · 15 currently recruiting

Type 2 Diabetes Mellitus is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 51 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 11 of these trials.

The research picture

Type 2 Diabetes Mellitus has 123 registered US clinical trials, 15 of them open to new participants right now, about 12% of the total.

15
recruiting participants now
12%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
11
top sponsor: AstraZeneca
Phase 128Phase 223Phase 316Phase 410

Active & Recent Trials

123 total, page 3 of 3

COMPLETED Phase 1 24 participants

A Drug to Drug Interaction Study of Sotagliflozin With Midazolam and Metoprolol

Sanofi

NCT02940379

COMPLETED Phase 1 24 participants

Single Cohort 4-period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine

Gilead Sciences

NCT01546597

COMPLETED Phase 1 24 participants

Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes

University of Colorado, Denver

NCT03620773

COMPLETED Phase 4 24 participants

Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes

Baylor College of Medicine

NCT01432405

COMPLETED Phase 1 24 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics After High Single Ascending Oral Doses of AZD1656 in T2DM Patients

AstraZeneca

NCT01221545

COMPLETED NA 24 participants

Pilot Study of the Effects of Erythritol on Endothelial Function in Patients With Type 2 Diabetes Mellitus

Boston University

NCT01609088

COMPLETED NA 23 participants

A Pilot Open Label Clinical Trial to Evaluate the Combined Impact of Two Mobile Health Products on Health Outcomes in Overweight Adults With Type 2 Diabetes

Medidata Solutions

NCT02227303

COMPLETED NA 22 participants

Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?

University of California, San Francisco

NCT02846233

COMPLETED Early Phase 1 20 participants

The Contribution of Incretin Hormones to Post-prandial Glucose Metabolism After Roux-en-Y Gastric Bypass

Adrian Vella

NCT01843881

COMPLETED NA 20 participants

Pilot Study Of The Effects Of Resveratrol On Endothelial Function In Subjects With Type 2 Diabetes Mellitus

Boston University

NCT01038089

COMPLETED NA 18 participants

Vitamin D and Adipose Tissue Inflammation

Fred Hutchinson Cancer Center

NCT01477034

COMPLETED NA 16 participants

The Set-Point Study for Type 2 Diabetes: Evaluating the Use of an Insulin Only Bionic Pancreas System in Type 2 Diabetes

Massachusetts General Hospital

NCT03552523

COMPLETED Phase 3 16 participants

Acute Metabolic Effects of LAF 237 in Type 2 Diabetics

The University of Texas Health Science Center at San Antonio

NCT00230464

COMPLETED Phase 1 15 participants

Study of Two Oral Formulations of LX4211 in Patients With Type 2 Diabetes Mellitus

Lexicon Pharmaceuticals

NCT01188863

COMPLETED Phase 1 14 participants

ECC5004 RBA FE Study in Healthy Participants

Eccogene

NCT06268145

COMPLETED Phase 2 14 participants

Anti-Inflammatory Small Drug Adjunctive Therapy for Type 2 Diabetes

Nick Giannoukakis, PhD

NCT02597101

COMPLETED Phase 2 13 participants

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Tolerability of Exenatide in Adolescent Subjects With Type 2 Diabetes Mellitus

AstraZeneca

NCT00254254

COMPLETED Phase 2 12 participants

The Effect of Bariatric Surgery on Metabolism, the Metabolome and Microbiome in Patients With Type 2 Diabetes

Mayo Clinic

NCT02762708

COMPLETED Phase 1 12 participants

A Study to Evaluate and Study Drug Levels in Blood Plasma When Giving High Doses of GSK189075 to Healthy Volunteers

GlaxoSmithKline

NCT00501930

COMPLETED NA 11 participants

Lipid, Glycemic, and Insulin Responses to Meals Rich in Different Fatty Acids

University of Texas Southwestern Medical Center

NCT00479791

COMPLETED Phase 3 9 participants

Impact of Gastric Bypass Surgery on Risk of CVD in Type 2 Diabetes Mellitus

Vanderbilt University

NCT00444392

COMPLETED Phase 1 7 participants

Study of the Absolute Oral Bioavailability of Dapagliflozin in Healthy Subjects

AstraZeneca

NCT00908271

COMPLETED Phase 2 5 participants

Medically Reproducing Bariatric Surgery

Moahad S Dar

NCT03225209

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Phase Distribution

PhaseTrial count
Phase 1 28
Phase 2 23
Phase 3 16
Phase 4 10

Top Sponsors

AstraZeneca 11 trials
Bayer 4 trials
Daiichi Sankyo 4 trials
Sanofi 4 trials
Gilead Sciences 3 trials
Pfizer 3 trials
Yale University 3 trials
GlaxoSmithKline 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 2 Diabetes Mellitus Trial Landscape

123 indexed Type 2 Diabetes Mellitus studies · 15 recruiting (12%).

Phase mix: 26 late (III/IV) vs 51 early (I/II).

Top sponsor: AstraZeneca (11 trials), 9 others listed. 23 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 2 Diabetes Mellitus?

PlainTrial tracks 123 US clinical trials for Type 2 Diabetes Mellitus, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 2 Diabetes Mellitus?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.