Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Type 2 Diabetes Mellitus clinical trials
15 of 123 indexed Type 2 Diabetes Mellitus trials are currently recruiting.
123 US clinical trials · 15 currently recruiting
Type 2 Diabetes Mellitus is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 51 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 11 of these trials.
The research picture
Type 2 Diabetes Mellitus has 123 registered US clinical trials, 15 of them open to new participants right now, about 12% of the total.
- 15
- recruiting participants now
- 12%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 11
- top sponsor: AstraZeneca
Active & Recent Trials
123 total, page 3 of 3
A Drug to Drug Interaction Study of Sotagliflozin With Midazolam and Metoprolol
Sanofi
NCT02940379
Single Cohort 4-period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine
Gilead Sciences
NCT01546597
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes
University of Colorado, Denver
NCT03620773
Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes
Baylor College of Medicine
NCT01432405
A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics After High Single Ascending Oral Doses of AZD1656 in T2DM Patients
AstraZeneca
NCT01221545
Pilot Study of the Effects of Erythritol on Endothelial Function in Patients With Type 2 Diabetes Mellitus
Boston University
NCT01609088
A Pilot Open Label Clinical Trial to Evaluate the Combined Impact of Two Mobile Health Products on Health Outcomes in Overweight Adults With Type 2 Diabetes
Medidata Solutions
NCT02227303
Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?
University of California, San Francisco
NCT02846233
The Contribution of Incretin Hormones to Post-prandial Glucose Metabolism After Roux-en-Y Gastric Bypass
Adrian Vella
NCT01843881
Pilot Study Of The Effects Of Resveratrol On Endothelial Function In Subjects With Type 2 Diabetes Mellitus
Boston University
NCT01038089
Vitamin D and Adipose Tissue Inflammation
Fred Hutchinson Cancer Center
NCT01477034
The Set-Point Study for Type 2 Diabetes: Evaluating the Use of an Insulin Only Bionic Pancreas System in Type 2 Diabetes
Massachusetts General Hospital
NCT03552523
Acute Metabolic Effects of LAF 237 in Type 2 Diabetics
The University of Texas Health Science Center at San Antonio
NCT00230464
Study of Two Oral Formulations of LX4211 in Patients With Type 2 Diabetes Mellitus
Lexicon Pharmaceuticals
NCT01188863
ECC5004 RBA FE Study in Healthy Participants
Eccogene
NCT06268145
Anti-Inflammatory Small Drug Adjunctive Therapy for Type 2 Diabetes
Nick Giannoukakis, PhD
NCT02597101
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Tolerability of Exenatide in Adolescent Subjects With Type 2 Diabetes Mellitus
AstraZeneca
NCT00254254
The Effect of Bariatric Surgery on Metabolism, the Metabolome and Microbiome in Patients With Type 2 Diabetes
Mayo Clinic
NCT02762708
A Study to Evaluate and Study Drug Levels in Blood Plasma When Giving High Doses of GSK189075 to Healthy Volunteers
GlaxoSmithKline
NCT00501930
Lipid, Glycemic, and Insulin Responses to Meals Rich in Different Fatty Acids
University of Texas Southwestern Medical Center
NCT00479791
Impact of Gastric Bypass Surgery on Risk of CVD in Type 2 Diabetes Mellitus
Vanderbilt University
NCT00444392
Study of the Absolute Oral Bioavailability of Dapagliflozin in Healthy Subjects
AstraZeneca
NCT00908271
Medically Reproducing Bariatric Surgery
Moahad S Dar
NCT03225209
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 23 |
| Phase 3 | 16 |
| Phase 4 | 10 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 2 Diabetes Mellitus Trial Landscape
123 indexed Type 2 Diabetes Mellitus studies · 15 recruiting (12%).
Phase mix: 26 late (III/IV) vs 51 early (I/II).
Top sponsor: AstraZeneca (11 trials), 9 others listed. 23 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 2 Diabetes Mellitus?
PlainTrial tracks 123 US clinical trials for Type 2 Diabetes Mellitus, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 2 Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.