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Actinic Keratosis: full-pipeline trial registry
2 of 17 indexed Actinic Keratosis trials are currently recruiting.
Corpus placement: #1,004 of 28,707 conditions by registered trial count.
17 US clinical trials · 2 currently recruiting · #1,004 of 28,707 conditions by registered trial count
Actinic Keratosis: 17 US clinical trials tracked, 2 recruiting.
Actinic Keratosis is the subject of 17 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Peplin, running 4 of these trials.
Enrollment posture brief
Registry condition actinic-keratosis
OPEN 2 | RECR 12% | LATE 9 | EARLY 7 | RANK #1004 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Gestational Diabetes Mellitus (12% recruiting · 17 trials)
Actinic Keratosis lists 2 open slots (12% of 17 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Actinic Keratosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Actinic Keratosis is recruiting below its size-band peers.
2 of 17 indexed trials (11.8%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Actinic Keratosis research.
Peplin accounts for 4 of 17 trials (23.5%). 12 distinct sponsors appear on at least one study for this condition label.
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Typical Actinic Keratosis enrolment sits around 117 participants.
Median target enrolment is 117 among the 17 trials that report a genuine target (sentinel values excluded). 7 of those (41.2%) plan for fewer than 100 participants.
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Actinic Keratosis research is mostly interventional.
16 interventional and 1 observational studies make up this index (94.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
17 total, page 1 of 1
The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans
VA Office of Research and Development
NCT06778434
The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy
Wright State University
NCT05688904
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities
Sun Pharmaceutical Industries
NCT07144852
Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp
Sun Pharmaceutical Industries
NCT07144345
Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients
University of Arizona
NCT05699603
Efficacy and Safety of Ingenol Mebutate Gel for Actinic Keratosis Applied on Large Area on Face, Scalp or Chest
LEO Pharma
NCT02361216
A Study of Equivalence of Generic Ingenol Mebutate Gel 0.05% and Picato Gel 0.05% in Subjects With Actinic Keratosis
Actavis
NCT02654769
Efficacy and Safety of LEO 43204 in Field Treatment of Actinic Keratosis on Face or Chest Including 12-month Follow-up
LEO Pharma
NCT02547233
A Multi-center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)
Peplin
NCT00916006
Actinic Keratosis Study
Washington University School of Medicine
NCT02019355
Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp
Galderma R&D
NCT00304239
A Long Term Follow up Study of Patients Who Have Completed the PEP005-016 or PEP005-025 Studies
Peplin
NCT00953732
PEP005 Gel - Evaluation of Local Tolerability After Exposure to Ingenol Mebutate Gel Followed by Hand Washing in Healthy Subjects
Peplin
NCT01302925
A Study to Evaluate the Photoallergic Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers
Peplin
NCT00850681
Ph 1, Single-Center, Safety, Tolerability & Pharmacokinetic Study of KX2 391 Ointment in Subj. w Actinic Keratosis
Athenex
NCT02337205
Clinical Trial to Evaluate Biafine Cream Versus Standard Care in Subjects With Actinic Keratosis Post Cryotherapy
Wake Forest University
NCT00695578
Safety and Efficacy of Ingenol Mebutate Gel 0.015% for Treatment of AK on the Face in Solid Organ Transplant Recipients
University of California, San Francisco
NCT02866695
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 2 |
| Phase 3 | 7 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Actinic Keratosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Actinic Keratosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Actinic Keratosis page
17 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 2 Actinic Keratosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Peplin sponsors the most Actinic Keratosis trials on record, review their full trial history before evaluating a specific study. See Peplin's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Actinic Keratosis condition card totals 17 registered trials; most-linked intervention Vehicle; top US site state Illinois. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.