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NCT00701051 · ClinicalTrials.gov registry record · NA
Exercise Training and Glucose Metabolism in Aging
A NA study of Type 2 Diabetes Mellitus and Impaired Glucose Tolerance (Prediabetes), sponsored by US Department of Veterans Affairs.
- Completed
- Registry status
- NA
- Development phase
- 90
- Enrollment target
- 1
- Study location
NCT00701051 is a NA study of Type 2 Diabetes Mellitus and Impaired Glucose Tolerance (Prediabetes) that has completed, run by US Department of Veterans Affairs. The registered enrollment target is 90 participants, below the 2,748-participant average among 122 other Type 2 Diabetes Mellitus trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.
The verdict
NCT00701051, a NA study of Type 2 Diabetes Mellitus and Impaired Glucose Tolerance (Prediabetes), has completed, sponsored by US Department of Veterans Affairs.
- COMPLETED
- Registry status
- NA
- Development phase
- 90 participants
- Enrollment target
- 1
- Study location
Study Summary
Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are affected. In older adults, glucose metabolism may be affected by reduced skeletal muscle capillary supply, which limits insulin, glucose, and oxygen delivery to skeletal muscle. Reduced capillary supply to skeletal muscle is found in older individuals with impaired glucose tolerance and we hypothesize that this is due to reduced vascular growth factor expression, and chronic inflammation. Further, we hypothesize that reversal of a sedentary lifestyle through aerobic exercise training will increase insulin signaling and vascular growth factor expression, as well as decrease inflammation, to increase capillary supply to skeletal muscle, which contributes to improved glucose metabolism in older adults. This study will: 1) Determine the mechanisms underlying reduced skeletal muscle capillarization in older adults with impaired glucose tolerance; and 2) Determine the effect of aerobic exercise training-induced increases in skeletal muscle capillarization on glucose metabolism in older adults.
Conditions Studied
Interventions
- BEHAVIORAL Aerobic exercise training
- BEHAVIORAL Detraining (cessation of exercise)
Study Locations (1)
Maryland
- VA Maryland Health Care System, Baltimore - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2006-10 |
| Est. Completion | 2012-06 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00701051
The ClinicalTrials.gov registry entry for NCT00701051 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,748-participant average among 122 other Type 2 Diabetes Mellitus trials with a reported enrollment target (97% lower). The listed sponsor is US Department of Veterans Affairs, which has 632 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Type 2 Diabetes Mellitus appearing as the primary indexed condition, and to 2 interventions - of which Aerobic exercise training is the first listed.
NCT00701051 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00701051 about?
NCT00701051 is a clinical study titled "Exercise Training and Glucose Metabolism in Aging". Diabetes and its associated complications affect more than 20 million Americans, and the prevalence of type 2 diabetes and impaired glucose tolerance rises dramatically with age such that 40% of Americans over age 60 are affected. In older adults, glucose metabolism may be affected by reduced skelet...
What is the current status of trial NCT00701051?
This trial is currently completed. It is a NA study. The enrollment target is 90 participants. The study started on 2006-10. Estimated completion is 2012-06.
What conditions does trial NCT00701051 study?
This clinical trial studies the following conditions: Type 2 Diabetes Mellitus, Impaired Glucose Tolerance (Prediabetes).
What interventions are being tested in trial NCT00701051?
The interventions under investigation include: Aerobic exercise training (BEHAVIORAL), Detraining (cessation of exercise) (BEHAVIORAL).
Who is sponsoring clinical trial NCT00701051?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00701051 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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