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Type 1 Diabetes: early-phase trial registry
79 of 199 indexed Type 1 Diabetes trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #50 of 28,707 conditions by registered trial count.
199 US clinical trials · 79 currently recruiting · #50 of 28,707 conditions by registered trial count
Type 1 Diabetes: 199 US clinical trials tracked, 79 recruiting.
Type 1 Diabetes is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 79 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 54 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 16 of these trials.
Enrollment posture brief
Registry condition type-1-diabetes
OPEN 79 | RECR 40% | LATE 21 | EARLY 54 | RANK #50 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Pregnancy (40% recruiting · 194 trials)
Type 1 Diabetes lists 79 open slots (40% of 199 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Type 1 Diabetes on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Type 1 Diabetes is recruiting above its size-band peers.
79 of 199 indexed trials (39.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Type 1 Diabetes trials is spread across many organizations.
University of Colorado, Denver accounts for 16 of 199 trials (8%). 97 distinct sponsors appear on at least one study for this condition label.
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Most Type 1 Diabetes trials plan to enrol fewer than 100 people.
Median target enrolment is 43 among the 199 trials that report a genuine target (sentinel values excluded). 141 of those (70.9%) plan for fewer than 100 participants.
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Type 1 Diabetes research is mostly interventional.
169 interventional and 30 observational studies make up this index (84.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
199 total, page 2 of 4
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
University of Virginia
NCT05653518
Using Simplified Meal Boluses Versus Carbohydrate Counting in Adolescents With Hybrid Closed Loop Systems
University of Colorado, Denver
NCT06575790
Effect of C-peptide on Hypoglycemic Counterregulation
University of Cincinnati
NCT06470295
Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use
Yale University
NCT06171412
AIDANET Pediatrics
Mark D. DeBoer, MD, MSc., MCR
NCT07020936
To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.
Viral N. Shah
NCT07287943
Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet
Boston Children's Hospital
NCT03710928
Extended Bolus for Meals in a Closed-loop System
University of California, San Francisco
NCT05454891
Lipoprotein Kinetics in T1D
University of Missouri-Columbia
NCT05179954
Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial
University of California, San Diego
NCT06981234
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
Portal Diabetes
NCT07341373
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
University of California, San Diego
NCT05696366
Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
Augusta University
NCT04449198
GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab
Vanderbilt University Medical Center
NCT06338553
Effects of Ketosis on Brain Function in Patients With T1DM
Boston Children's Hospital
NCT04219709
Multivariable Artificial Pancreas: Detecting and Mitigating Unannounced Physical Activity and Acute Psychological Stress
University of Illinois at Chicago
NCT05145374
Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D
Mark D. DeBoer, MD, MSc., MCR
NCT06948760
BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes
Stanford University
NCT05488119
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings
NCT05626712
REAL-Fam Feasibility Study for Youth Diabetes Management
University of North Carolina, Chapel Hill
NCT07212790
Safety and Feasibility of a Machine-Learning Bolus Priming Added to Existing Control Algorithm
Sue Brown
NCT06728059
Resistance Training in Type 1 Diabetes Mellitus
University of Louisville
NCT05315037
Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes
Yale University
NCT06105931
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory
NCT06575426
Very Low Carbohydrate Diets and Glucagon Response in T1DM
Boston Children's Hospital
NCT04200391
An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant
Vertex Pharmaceuticals Incorporated
NCT06832410
Closed Loop Context Aware AID
Oregon Health and Science University
NCT06676657
Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
University of Cincinnati
NCT05973799
Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 Diabetes Using Automated Insulin Delivery
Anas El Fathi
NCT07212179
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06914895
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes
Joslin Diabetes Center
NCT04595474
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06962280
FAMS-T1D Self-Regulation and Social Support for T1D
University of Utah
NCT05820477
Multi-Site Eating Disorder Prevention Program for Type 1 Diabetes
Oslo University Hospital
NCT05399446
iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes
University Hospitals Cleveland Medical Center
NCT06348160
Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes
University of Illinois at Chicago
NCT04506151
PS230005 Control-IQ 1.5 Post-Approval Study
Tandem Diabetes Care
NCT06717451
Adapting FAMS to Optimize CGM Use Among Emerging Adults With Type 1 Diabetes
Vanderbilt University Medical Center
NCT05854069
Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes
Virginia Commonwealth University
NCT05639088
Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes
Children's Mercy Hospital Kansas City
NCT06412601
Research on Optimizing the Use of Technology With Education
Children's National Research Institute
NCT05564481
Reducing Innate Inflammation in New Onset Type 1 Diabetes
Medical College of Wisconsin
NCT04335656
The T1D Parent Check-In: A Preventative Intervention
Massachusetts General Hospital
NCT06160934
Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care
Massachusetts General Hospital
NCT05229718
Probiotics in Newly Diagnosed T1D
Medical College of Wisconsin
NCT04141761
A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients
Northwestern University
NCT01897688
Type 1 Diabetes Education and Support Study
Kaiser Permanente
NCT05735340
Fully Closed Loop At Home (FCL@Home)
University of Colorado, Denver
NCT06041971
Evaluating the InPen in Pediatric Type 1 Diabetes
Wayne State University
NCT05515939
Diabetes Inspired Culinary Education (DICE): Culinary Medicine Intervention for At-Risk Youth With Type 1 Diabetes
Case Western Reserve University
NCT07084805
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 30 |
| Phase 2 | 24 |
| Phase 3 | 11 |
| Phase 4 | 10 |
Top Sponsors
Named interventions
Most-linked intervention names on Type 1 Diabetes records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Type 1 Diabetes trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Type 1 Diabetes page
199 registered trials, 79 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 79 Type 1 Diabetes trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Colorado, Denver sponsors the most Type 1 Diabetes trials on record, review their full trial history before evaluating a specific study. See University of Colorado, Denver's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Type 1 Diabetes condition card totals 199 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.