Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Type 1 Diabetes clinical trials
69 of 179 indexed Type 1 Diabetes trials are currently recruiting.
179 US clinical trials · 69 currently recruiting
Type 1 Diabetes is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 69 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 50 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 14 of these trials.
The research picture
Type 1 Diabetes has 179 registered US clinical trials, 69 of them open to new participants right now, about 39% of the total.
- 69
- recruiting participants now
- 39%
- of trials open to enrollment
- 19
- in Phase 3–4 (later-stage)
- 14
- top sponsor: University of Colorado, Denver
Active & Recent Trials
179 total, page 2 of 4
To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.
Viral N. Shah
NCT07287943
Extended Bolus for Meals in a Closed-loop System
University of California, San Francisco
NCT05454891
Lipoprotein Kinetics in T1D
University of Missouri-Columbia
NCT05179954
Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial
University of California, San Diego
NCT06981234
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
Portal Diabetes
NCT07341373
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
University of California, San Diego
NCT05696366
Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
Augusta University
NCT04449198
GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab
Vanderbilt University Medical Center
NCT06338553
Multivariable Artificial Pancreas: Detecting and Mitigating Unannounced Physical Activity and Acute Psychological Stress
University of Illinois at Chicago
NCT05145374
Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D
Mark D. DeBoer, MD, MSc., MCR
NCT06948760
BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes
Stanford University
NCT05488119
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Creative Medical Technology Holdings
NCT05626712
REAL-Fam Feasibility Study for Youth Diabetes Management
University of North Carolina, Chapel Hill
NCT07212790
Safety and Feasibility of a Machine-Learning Bolus Priming Added to Existing Control Algorithm
Sue Brown
NCT06728059
Resistance Training in Type 1 Diabetes Mellitus
University of Louisville
NCT05315037
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Otsuka Pharmaceutical Factory
NCT06575426
An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant
Vertex Pharmaceuticals Incorporated
NCT06832410
Closed Loop Context Aware AID
Oregon Health and Science University
NCT06676657
Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 Diabetes Using Automated Insulin Delivery
Anas El Fathi
NCT07212179
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06914895
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes
Joslin Diabetes Center
NCT04595474
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
Eli Lilly and Company
NCT06962280
FAMS-T1D Self-Regulation and Social Support for T1D
University of Utah
NCT05820477
Multi-Site Eating Disorder Prevention Program for Type 1 Diabetes
Oslo University Hospital
NCT05399446
iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes
University Hospitals Cleveland Medical Center
NCT06348160
Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes
University of Illinois at Chicago
NCT04506151
PS230005 Control-IQ 1.5 Post-Approval Study
Tandem Diabetes Care
NCT06717451
Adapting FAMS to Optimize CGM Use Among Emerging Adults With Type 1 Diabetes
Vanderbilt University Medical Center
NCT05854069
Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes
Virginia Commonwealth University
NCT05639088
Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes
Children's Mercy Hospital Kansas City
NCT06412601
Research on Optimizing the Use of Technology With Education
Children's National Research Institute
NCT05564481
Reducing Innate Inflammation in New Onset Type 1 Diabetes
Medical College of Wisconsin
NCT04335656
The T1D Parent Check-In: A Preventative Intervention
Massachusetts General Hospital
NCT06160934
Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care
Massachusetts General Hospital
NCT05229718
Probiotics in Newly Diagnosed T1D
Medical College of Wisconsin
NCT04141761
A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients
Northwestern University
NCT01897688
Fully Closed Loop At Home (FCL@Home)
University of Colorado, Denver
NCT06041971
Evaluating the InPen in Pediatric Type 1 Diabetes
Wayne State University
NCT05515939
Diabetes Inspired Culinary Education (DICE): Culinary Medicine Intervention for At-Risk Youth With Type 1 Diabetes
Case Western Reserve University
NCT07084805
Effects of GRA in Patients With Type 1
University of California, San Diego
NCT04779645
Development of Novel Biomarkers for the Early Diagnosis of Type 1 Diabetes
AdventHealth Translational Research Institute
NCT04164966
Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes
Children's Hospital of Philadelphia
NCT04238949
A 12-week Pilot Nutrition Intervention for Children With New Diagnosis of Stage 3 Type 1 Diabetes (T1D)
Milton S. Hershey Medical Center
NCT06640478
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
Vertex Pharmaceuticals Incorporated
NCT05791201
Extension for Community Health Outcomes (ECHO) Diabetes Program
University of Florida
NCT06552923
Family Management of Childhood Diabetes Study
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00340938
A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy
Eli Lilly and Company
NCT05463744
A 2-Month Safety Follow-Up Trial
Mannkind Corporation
NCT00741429
Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving.Com)
University of Virginia
NCT01563887
Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy
Medtronic Diabetes
NCT00417989
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 27 |
| Phase 2 | 23 |
| Phase 3 | 10 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 1 Diabetes Trial Landscape
179 indexed Type 1 Diabetes studies · 69 recruiting (39%).
Phase mix: 19 late (III/IV) vs 50 early (I/II).
Top sponsor: University of Colorado, Denver (14 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 1 Diabetes?
PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 1 Diabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.