Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 69 recruiting now official registry

Type 1 Diabetes clinical trials

69 of 179 indexed Type 1 Diabetes trials are currently recruiting.

179 US clinical trials · 69 currently recruiting

Type 1 Diabetes is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 69 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 50 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 14 of these trials.

The research picture

Type 1 Diabetes has 179 registered US clinical trials, 69 of them open to new participants right now, about 39% of the total.

69
recruiting participants now
39%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
14
top sponsor: University of Colorado, Denver
Phase 127Phase 223Phase 310Phase 49

Active & Recent Trials

179 total, page 2 of 4

RECRUITING NA 34 participants

To Study the Efficacy and Safety of Medtronic 780G Insulin Pump in People With Gastroparesis and Type 1 Diabetes.

Viral N. Shah

NCT07287943

RECRUITING Phase 4 30 participants

Extended Bolus for Meals in a Closed-loop System

University of California, San Francisco

NCT05454891

RECRUITING NA 30 participants

Lipoprotein Kinetics in T1D

University of Missouri-Columbia

NCT05179954

RECRUITING Phase 2 25 participants

Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial

University of California, San Diego

NCT06981234

RECRUITING Phase 1 25 participants

A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500

Portal Diabetes

NCT07341373

RECRUITING Phase 1 24 participants

Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes

University of California, San Diego

NCT05696366

RECRUITING Early Phase 1 24 participants

Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1

Augusta University

NCT04449198

RECRUITING Early Phase 1 24 participants

GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab

Vanderbilt University Medical Center

NCT06338553

RECRUITING 20 participants

Multivariable Artificial Pancreas: Detecting and Mitigating Unannounced Physical Activity and Acute Psychological Stress

University of Illinois at Chicago

NCT05145374

RECRUITING NA 20 participants

Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D

Mark D. DeBoer, MD, MSc., MCR

NCT06948760

RECRUITING NA 20 participants

BEAD-T1D: Building the Evidence to Address Disengagement in Type 1 Diabetes

Stanford University

NCT05488119

RECRUITING Phase 1 18 participants

Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes

Creative Medical Technology Holdings

NCT05626712

RECRUITING NA 16 participants

REAL-Fam Feasibility Study for Youth Diabetes Management

University of North Carolina, Chapel Hill

NCT07212790

RECRUITING NA 16 participants

Safety and Feasibility of a Machine-Learning Bolus Priming Added to Existing Control Algorithm

Sue Brown

NCT06728059

RECRUITING NA 15 participants

Resistance Training in Type 1 Diabetes Mellitus

University of Louisville

NCT05315037

RECRUITING Phase 1 13 participants

A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus

Otsuka Pharmaceutical Factory

NCT06575426

RECRUITING Phase 3 10 participants

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

Vertex Pharmaceuticals Incorporated

NCT06832410

RECRUITING NA 10 participants

Closed Loop Context Aware AID

Oregon Health and Science University

NCT06676657

RECRUITING NA 6 participants

Safety and Feasibility of a Self-Learning Bolus Calculator With Simplified Meal Announcement in Adolescents With Type 1 Diabetes Using Automated Insulin Delivery

Anas El Fathi

NCT07212179

ACTIVE NOT RECRUITING Phase 3 905 participants

A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06914895

ACTIVE NOT RECRUITING 533 participants

Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes

Joslin Diabetes Center

NCT04595474

ACTIVE NOT RECRUITING Phase 3 465 participants

A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight

Eli Lilly and Company

NCT06962280

ACTIVE NOT RECRUITING NA 280 participants

FAMS-T1D Self-Regulation and Social Support for T1D

University of Utah

NCT05820477

ACTIVE NOT RECRUITING NA 280 participants

Multi-Site Eating Disorder Prevention Program for Type 1 Diabetes

Oslo University Hospital

NCT05399446

ACTIVE NOT RECRUITING NA 195 participants

iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes

University Hospitals Cleveland Medical Center

NCT06348160

ACTIVE NOT RECRUITING NA 144 participants

Sleep Optimization to Improve Glycemic Control in Adults With Type 1 Diabetes

University of Illinois at Chicago

NCT04506151

ACTIVE NOT RECRUITING 144 participants

PS230005 Control-IQ 1.5 Post-Approval Study

Tandem Diabetes Care

NCT06717451

ACTIVE NOT RECRUITING NA 140 participants

Adapting FAMS to Optimize CGM Use Among Emerging Adults With Type 1 Diabetes

Vanderbilt University Medical Center

NCT05854069

ACTIVE NOT RECRUITING NA 109 participants

Improving Transition Care for Adolescents and Young Adults With Type 1 Diabetes

Virginia Commonwealth University

NCT05639088

ACTIVE NOT RECRUITING NA 80 participants

Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes

Children's Mercy Hospital Kansas City

NCT06412601

ACTIVE NOT RECRUITING NA 60 participants

Research on Optimizing the Use of Technology With Education

Children's National Research Institute

NCT05564481

ACTIVE NOT RECRUITING Phase 2 60 participants

Reducing Innate Inflammation in New Onset Type 1 Diabetes

Medical College of Wisconsin

NCT04335656

ACTIVE NOT RECRUITING NA 50 participants

The T1D Parent Check-In: A Preventative Intervention

Massachusetts General Hospital

NCT06160934

ACTIVE NOT RECRUITING NA 45 participants

Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care

Massachusetts General Hospital

NCT05229718

ACTIVE NOT RECRUITING Phase 2 43 participants

Probiotics in Newly Diagnosed T1D

Medical College of Wisconsin

NCT04141761

ACTIVE NOT RECRUITING Phase 3 40 participants

A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients

Northwestern University

NCT01897688

ACTIVE NOT RECRUITING NA 36 participants

Fully Closed Loop At Home (FCL@Home)

University of Colorado, Denver

NCT06041971

ACTIVE NOT RECRUITING 34 participants

Evaluating the InPen in Pediatric Type 1 Diabetes

Wayne State University

NCT05515939

ACTIVE NOT RECRUITING NA 32 participants

Diabetes Inspired Culinary Education (DICE): Culinary Medicine Intervention for At-Risk Youth With Type 1 Diabetes

Case Western Reserve University

NCT07084805

ACTIVE NOT RECRUITING Phase 2 30 participants

Effects of GRA in Patients With Type 1

University of California, San Diego

NCT04779645

ACTIVE NOT RECRUITING 28 participants

Development of Novel Biomarkers for the Early Diagnosis of Type 1 Diabetes

AdventHealth Translational Research Institute

NCT04164966

ACTIVE NOT RECRUITING NA 28 participants

Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes

Children's Hospital of Philadelphia

NCT04238949

ACTIVE NOT RECRUITING NA 20 participants

A 12-week Pilot Nutrition Intervention for Children With New Diagnosis of Stage 3 Type 1 Diabetes (T1D)

Milton S. Hershey Medical Center

NCT06640478

ACTIVE NOT RECRUITING Phase 1 7 participants

A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes

Vertex Pharmaceuticals Incorporated

NCT05791201

COMPLETED NA 32,796 participants

Extension for Community Health Outcomes (ECHO) Diabetes Program

University of Florida

NCT06552923

COMPLETED Phase 1 1,298 participants

Family Management of Childhood Diabetes Study

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00340938

COMPLETED Phase 3 692 participants

A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapy

Eli Lilly and Company

NCT05463744

COMPLETED 649 participants

A 2-Month Safety Follow-Up Trial

Mannkind Corporation

NCT00741429

COMPLETED NA 568 participants

Identifying Driving Risk Factors in Type 1 Diabetes and Their Reduction Via Internet Program (DiabetesDriving.Com)

University of Virginia

NCT01563887

COMPLETED NA 485 participants

Study to Compare Efficacy of the MiniMed Paradigm REAL-Time System Vs. MDI in Subjects Naive to Insulin Pump Therapy

Medtronic Diabetes

NCT00417989

← Previous Page 2 of 4 Next →

Phase Distribution

PhaseTrial count
Phase 1 27
Phase 2 23
Phase 3 10
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 1 Diabetes Trial Landscape

179 indexed Type 1 Diabetes studies · 69 recruiting (39%).

Phase mix: 19 late (III/IV) vs 50 early (I/II).

Top sponsor: University of Colorado, Denver (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 1 Diabetes?

PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 1 Diabetes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.