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Type 1 Diabetes clinical trials
69 of 179 indexed Type 1 Diabetes trials are currently recruiting.
179 US clinical trials · 69 currently recruiting
Type 1 Diabetes is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 69 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 50 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 14 of these trials.
The research picture
Type 1 Diabetes has 179 registered US clinical trials, 69 of them open to new participants right now, about 39% of the total.
- 69
- recruiting participants now
- 39%
- of trials open to enrollment
- 19
- in Phase 3–4 (later-stage)
- 14
- top sponsor: University of Colorado, Denver
Active & Recent Trials
179 total, page 3 of 4
Randomized Study of Real-Time Continuous Glucose Monitors (RT-CGM) in the Management of Type 1 Diabetes
Jaeb Center for Health Research
NCT00406133
Sweetgoals for Type 1 Diabetes
Trustees of Dartmouth College
NCT04646473
Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus
Yale University
NCT00580710
Characteristics of Persons With an Eating Disorder and Type 1 Diabetes
HealthPartners Institute
NCT00945711
Automated Insulin Delivery for Inpatients With Dysglycemia
Emory University
NCT06418880
Can Glucose Monitoring Improve (CGMi Study)
Joslin Diabetes Center
NCT01472159
Testing MST to Improve Adherence Among Youth With Chronic Poor Metabolic Control
Wayne State University
NCT00519935
ADJUnct Semaglutide Treatment in Type 1 Diabetes
Viral N. Shah
NCT05537233
Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 Diabetes
University of Colorado, Denver
NCT02544321
Effect of Apidra Compared to Humalog in Decreasing Post-Prandial Hyperglycemia
University of Florida
NCT01621776
In Clinic Evaluation of the PLGM Feature
Medtronic Diabetes
NCT02130284
Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus
Gianna Wilkie
NCT04599075
Assessment of Sleep and Sleep Disruptors in Adolescents With Type 1 Diabetes
University of Colorado, Denver
NCT05370339
PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
Mesoblast
NCT00690066
Early Markers of Disease and Response to Therapy
Sandra Lord, MD
NCT04118153
Lantus in the Treatment of Type 1 Diabetes Children
Baylor College of Medicine
NCT00206401
Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose
University of Washington
NCT04623086
Insulet Artificial Pancreas Early Feasibility Study
Insulet Corporation
NCT02897557
Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System
Jaeb Center for Health Research
NCT01271023
Eating Disorder Prevention Program for Women With T1D
Stanford University
NCT05264376
Monocyte Function and Inflammation in Type 1 Diabetes and Its Modulation
University of California, Davis
NCT00441844
Diabetes Closed-Loop Project 6 (DCLP6): Fully Automated Closed-Loop Control in Type 1 Diabetes Using Meal Anticipation
University of Virginia
NCT04877730
Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes
Benjamin U. Nwosu, MD
NCT03046927
Hypoglycemia Associated Autonomic Failure in Type 1 DM
Vanderbilt University
NCT00592670
Analysis of B Cells From Autoimmune Individuals
University of Colorado, Denver
NCT02747277
Impact of Hybrid Closed-Loop Systems on Sleep and Psychosocial Outcomes in Youth With T1D and Their Parents
University of Colorado, Denver
NCT04431947
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes
University of Colorado, Denver
NCT02502071
School Centered Telemedicine Program for Children With Type 1 Diabetes Mellitus
State University of New York - Upstate Medical University
NCT00566475
HCT Cash-Only INcentive to Promote Mealtime Insulin DOSE Engagement
Children's Mercy Hospital Kansas City
NCT04621890
Promoting Adolescent Investment In Diabetes Care
Harvard Pilgrim Health Care
NCT04516694
Self-Management in Young Adults With Type 1 Diabetes
Case Western Reserve University
NCT04975230
Effect of Vitamin D on the Honeymoon Period in Children and Adolescents With Type 1 Diabetes
Nationwide Children's Hospital
NCT01724190
Lunch Time Insulin Injection by School Nurse for Poorly Controlled Diabetes
Baylor College of Medicine
NCT00340613
Use of Mobile-based Technologies to Improve Diabetes Self-management and Postprandial Glucose Control
Joslin Diabetes Center
NCT02556398
Measurement of Glucose Metabolism in Humans: Effect of Recurrent Hypoglycemia on Hypothalamic GABA
University of Minnesota
NCT02829593
The Pediatric Artificial Pancreas Automated Initialization Trial
Marc Breton
NCT06017089
Selecting Insulin Analogs for Closed-Loop Control Using Multiplex Pharmacokinetic Profiling
Massachusetts General Hospital
NCT01684943
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
University of Virginia
NCT03174288
Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use
Jaeb Center for Health Research
NCT02137512
Context Aware Data Gathering Study
Oregon Health and Science University
NCT04154904
Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes
University of Colorado, Denver
NCT01816165
Primary Intervention With Mucosal Insulin
University of Colorado, Denver
NCT02620553
Assessment of a Decision Support Tool in Participants With Type 1 Diabetes
Oregon Health and Science University
NCT04428645
Two Way Crossover Closed Loop Study MPC vs FMPD
Oregon Health and Science University
NCT04771403
The Set-Point Study: Evaluating Effects of Changing Glucose Target on Bionic Pancreas Performance
Massachusetts General Hospital
NCT02509065
Digital Exercise for Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes
Yale University
NCT06098729
A Study of Rapid-Acting Mealtime Insulin in Children and Adolescents With Newly Diagnosed Type 1 Diabetes Mellitus
Emory University
NCT04157738
Evaluation of Extended Infusion Set Wear Using Medtronic Extended Wear Sof-set Infusion Set
Stanford University
NCT02687256
Three-way, Cross-over Closed-loop Exercise Study
Oregon Health and Science University
NCT02241889
A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes
Baylor College of Medicine
NCT01718093
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 27 |
| Phase 2 | 23 |
| Phase 3 | 10 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 1 Diabetes Trial Landscape
179 indexed Type 1 Diabetes studies · 69 recruiting (39%).
Phase mix: 19 late (III/IV) vs 50 early (I/II).
Top sponsor: University of Colorado, Denver (14 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 1 Diabetes?
PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 1 Diabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.