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ClinicalTrials.gov 69 recruiting now official registry

Type 1 Diabetes clinical trials

69 of 179 indexed Type 1 Diabetes trials are currently recruiting.

179 US clinical trials · 69 currently recruiting

Type 1 Diabetes is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 69 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 50 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 14 of these trials.

The research picture

Type 1 Diabetes has 179 registered US clinical trials, 69 of them open to new participants right now, about 39% of the total.

69
recruiting participants now
39%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
14
top sponsor: University of Colorado, Denver
Phase 127Phase 223Phase 310Phase 49

Active & Recent Trials

179 total, page 3 of 4

COMPLETED Phase 3 451 participants

Randomized Study of Real-Time Continuous Glucose Monitors (RT-CGM) in the Management of Type 1 Diabetes

Jaeb Center for Health Research

NCT00406133

COMPLETED NA 300 participants

Sweetgoals for Type 1 Diabetes

Trustees of Dartmouth College

NCT04646473

COMPLETED 164 participants

Investigation Into the Effects Upon Brain Response to Change in Circulating Glucose Levels in Diabetes Mellitus

Yale University

NCT00580710

COMPLETED 154 participants

Characteristics of Persons With an Eating Disorder and Type 1 Diabetes

HealthPartners Institute

NCT00945711

COMPLETED Phase 3 130 participants

Automated Insulin Delivery for Inpatients With Dysglycemia

Emory University

NCT06418880

COMPLETED NA 130 participants

Can Glucose Monitoring Improve (CGMi Study)

Joslin Diabetes Center

NCT01472159

COMPLETED NA 127 participants

Testing MST to Improve Adherence Among Youth With Chronic Poor Metabolic Control

Wayne State University

NCT00519935

COMPLETED Phase 2 115 participants

ADJUnct Semaglutide Treatment in Type 1 Diabetes

Viral N. Shah

NCT05537233

COMPLETED Phase 2 108 participants

Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 Diabetes

University of Colorado, Denver

NCT02544321

COMPLETED NA 107 participants

Effect of Apidra Compared to Humalog in Decreasing Post-Prandial Hyperglycemia

University of Florida

NCT01621776

COMPLETED NA 80 participants

In Clinic Evaluation of the PLGM Feature

Medtronic Diabetes

NCT02130284

COMPLETED Phase 4 70 participants

Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus

Gianna Wilkie

NCT04599075

COMPLETED 70 participants

Assessment of Sleep and Sleep Disruptors in Adolescents With Type 1 Diabetes

University of Colorado, Denver

NCT05370339

COMPLETED Phase 2 63 participants

PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)

Mesoblast

NCT00690066

COMPLETED Early Phase 1 60 participants

Early Markers of Disease and Response to Therapy

Sandra Lord, MD

NCT04118153

COMPLETED Phase 4 60 participants

Lantus in the Treatment of Type 1 Diabetes Children

Baylor College of Medicine

NCT00206401

COMPLETED Phase 4 59 participants

Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose

University of Washington

NCT04623086

COMPLETED NA 59 participants

Insulet Artificial Pancreas Early Feasibility Study

Insulet Corporation

NCT02897557

COMPLETED Phase 1 57 participants

Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System

Jaeb Center for Health Research

NCT01271023

COMPLETED NA 55 participants

Eating Disorder Prevention Program for Women With T1D

Stanford University

NCT05264376

COMPLETED Phase 2 50 participants

Monocyte Function and Inflammation in Type 1 Diabetes and Its Modulation

University of California, Davis

NCT00441844

COMPLETED NA 50 participants

Diabetes Closed-Loop Project 6 (DCLP6): Fully Automated Closed-Loop Control in Type 1 Diabetes Using Meal Anticipation

University of Virginia

NCT04877730

COMPLETED Phase 2 48 participants

Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes

Benjamin U. Nwosu, MD

NCT03046927

COMPLETED NA 48 participants

Hypoglycemia Associated Autonomic Failure in Type 1 DM

Vanderbilt University

NCT00592670

COMPLETED 46 participants

Analysis of B Cells From Autoimmune Individuals

University of Colorado, Denver

NCT02747277

COMPLETED 46 participants

Impact of Hybrid Closed-Loop Systems on Sleep and Psychosocial Outcomes in Youth With T1D and Their Parents

University of Colorado, Denver

NCT04431947

COMPLETED Phase 4 45 participants

Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes

University of Colorado, Denver

NCT02502071

COMPLETED NA 41 participants

School Centered Telemedicine Program for Children With Type 1 Diabetes Mellitus

State University of New York - Upstate Medical University

NCT00566475

COMPLETED NA 39 participants

HCT Cash-Only INcentive to Promote Mealtime Insulin DOSE Engagement

Children's Mercy Hospital Kansas City

NCT04621890

COMPLETED NA 39 participants

Promoting Adolescent Investment In Diabetes Care

Harvard Pilgrim Health Care

NCT04516694

COMPLETED NA 39 participants

Self-Management in Young Adults With Type 1 Diabetes

Case Western Reserve University

NCT04975230

COMPLETED NA 38 participants

Effect of Vitamin D on the Honeymoon Period in Children and Adolescents With Type 1 Diabetes

Nationwide Children's Hospital

NCT01724190

COMPLETED Phase 4 36 participants

Lunch Time Insulin Injection by School Nurse for Poorly Controlled Diabetes

Baylor College of Medicine

NCT00340613

COMPLETED NA 35 participants

Use of Mobile-based Technologies to Improve Diabetes Self-management and Postprandial Glucose Control

Joslin Diabetes Center

NCT02556398

COMPLETED NA 34 participants

Measurement of Glucose Metabolism in Humans: Effect of Recurrent Hypoglycemia on Hypothalamic GABA

University of Minnesota

NCT02829593

COMPLETED NA 33 participants

The Pediatric Artificial Pancreas Automated Initialization Trial

Marc Breton

NCT06017089

COMPLETED NA 33 participants

Selecting Insulin Analogs for Closed-Loop Control Using Multiplex Pharmacokinetic Profiling

Massachusetts General Hospital

NCT01684943

COMPLETED NA 32 participants

The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes

University of Virginia

NCT03174288

COMPLETED NA 30 participants

Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use

Jaeb Center for Health Research

NCT02137512

COMPLETED NA 30 participants

Context Aware Data Gathering Study

Oregon Health and Science University

NCT04154904

COMPLETED Phase 3 28 participants

Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes

University of Colorado, Denver

NCT01816165

COMPLETED Phase 1 25 participants

Primary Intervention With Mucosal Insulin

University of Colorado, Denver

NCT02620553

COMPLETED NA 25 participants

Assessment of a Decision Support Tool in Participants With Type 1 Diabetes

Oregon Health and Science University

NCT04428645

COMPLETED NA 25 participants

Two Way Crossover Closed Loop Study MPC vs FMPD

Oregon Health and Science University

NCT04771403

COMPLETED NA 24 participants

The Set-Point Study: Evaluating Effects of Changing Glucose Target on Bionic Pancreas Performance

Massachusetts General Hospital

NCT02509065

COMPLETED NA 24 participants

Digital Exercise for Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes

Yale University

NCT06098729

COMPLETED Phase 4 24 participants

A Study of Rapid-Acting Mealtime Insulin in Children and Adolescents With Newly Diagnosed Type 1 Diabetes Mellitus

Emory University

NCT04157738

COMPLETED Phase 1 24 participants

Evaluation of Extended Infusion Set Wear Using Medtronic Extended Wear Sof-set Infusion Set

Stanford University

NCT02687256

COMPLETED NA 23 participants

Three-way, Cross-over Closed-loop Exercise Study

Oregon Health and Science University

NCT02241889

COMPLETED Phase 4 21 participants

A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes

Baylor College of Medicine

NCT01718093

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Phase Distribution

PhaseTrial count
Phase 1 27
Phase 2 23
Phase 3 10
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Type 1 Diabetes Trial Landscape

179 indexed Type 1 Diabetes studies · 69 recruiting (39%).

Phase mix: 19 late (III/IV) vs 50 early (I/II).

Top sponsor: University of Colorado, Denver (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Type 1 Diabetes?

PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Type 1 Diabetes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.