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Type 1 Diabetes clinical trials
69 of 179 indexed Type 1 Diabetes trials are currently recruiting.
179 US clinical trials · 69 currently recruiting
Type 1 Diabetes is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 69 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 50 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 14 of these trials.
The research picture
Type 1 Diabetes has 179 registered US clinical trials, 69 of them open to new participants right now, about 39% of the total.
- 69
- recruiting participants now
- 39%
- of trials open to enrollment
- 19
- in Phase 3–4 (later-stage)
- 14
- top sponsor: University of Colorado, Denver
Active & Recent Trials
179 total, page 1 of 4
The T1D Exchange Registry
T1D Exchange, United States
NCT04629586
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery
Sanford Health
NCT04477928
PRenatal and Obstetric Maternal Exposures and ISlet Autoantibodies in Early Life
University of Colorado, Denver
NCT06141434
Immune Function and the Progression to T1D
University of Florida
NCT05899439
Post Market Registry for the Omnipod 5 System in Children and Adults With Type 1 Diabetes
Insulet Corporation
NCT06144554
The iLet Experience Study
Beta Bionics
NCT06891898
Commercial or Open Source Closed Loop Impact on Pregnancy Study
University of California, San Francisco
NCT06654713
A Longitudinal, Observational Study Comparing Real-World Experiences of Teplizumab-Treated and Untreated Participants With Stage 2 Type 1 Diabetes in the United States
Sanofi
NCT07260110
ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2
Johns Hopkins University
NCT05463289
EMPoWER Study - Strengths-based Behavioral Intervention for Youth With Type 1 Diabetes
Baylor College of Medicine
NCT06014879
ACT1VATE: Addressing Emotional Distress to Improve Outcomes Among Diverse Adults With Type 1 Diabetes
Scripps Whittier Diabetes Institute
NCT04933851
Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes
Duke University
NCT05540704
Family Intervention for Black Teens With Type 1 Diabetes
Wayne State University
NCT06275412
Accessing Care, Clinical Trials and Screening for Underserved Children and Adults With Type 1 Diabetes (ACCESS-T1D)
AdventHealth Translational Research Institute
NCT06908057
Registry for Stage 2 Type 1 Diabetes
Sanofi
NCT06481904
Remedy to Diabetes Distress (R2D2): A Scalable Screen to Treat Program for School-age Families
Nemours Children's Clinic
NCT05268250
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
SAb Biotherapeutics
NCT07187531
Impact of MEnstruation on Glycemic Response and Exercise In Females With Type 1 Diabetes
University of Colorado, Denver
NCT06297980
Sleep Coach for Adolescents With Type 1 Diabetes
Vanderbilt University Medical Center
NCT06516614
Discovery Diabetes
Vanderbilt University Medical Center
NCT07116434
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
NYU Langone Health
NCT05641753
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
City of Hope Medical Center
NCT07061574
Accuracy of Continuous Glucose Monitors During the Perioperative Period in Youth With Type 1 Diabetes
University of Colorado, Denver
NCT06575842
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Heba M. Ismail
NCT05414409
A Study Comparing Dexcom Continuous Glucose Monitoring to Point of Care Glucose Testing for the Management of Hospital and Post-Discharge Subjects With Type 1 Diabetes
Emory University
NCT06752928
Pathogenesis of Kidney Disease in Type 1 Diabetes: a Modern Kidney Biopsy Cohort (The PANDA Study)
University of Colorado, Denver
NCT05319990
T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes
Yale University
NCT07059806
Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years
Massachusetts General Hospital
NCT05866536
InvesT1D: Promoting Adolescent Investment in Diabetes Care
Harvard Pilgrim Health Care
NCT06384911
Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression
Albert Einstein College of Medicine
NCT05734313
Reducing Diabetes Distress Using Cognitive Behavioral Therapy in Young Adults With Type 1 Diabetes
Albert Einstein College of Medicine
NCT05000021
Skeletal Effects of Type 1 Diabetes on Low-Trauma Fracture Risk
Creighton University
NCT05701254
Transdisciplinary Care for Young Adults With Type 1 Diabetes
Nemours Children's Clinic
NCT06172166
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
COUR Pharmaceutical Development Company
NCT06783309
TArgeting Type 1 Diabetes Using POLyamines (TADPOL)
Emily K. Sims
NCT05594563
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Kalie Tommerdahl
NCT05065372
Precision Administration of Anti-thymocyte Globulin With or Without Verapamil
University of Florida
NCT06455319
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
University of Washington
NCT05822609
Home-based Oral Glucose Tolerance Test for Type 1 Diabetes Screening
Yale University
NCT07155252
The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
Mayo Clinic
NCT06976619
GO TEAM: Glucose Optimization Through Technology Assisted Management
Sarah MacLeish
NCT06074458
Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes
Throne Biotechnologies
NCT04011020
Denosumab for Type 1 Diabetes
City of Hope Medical Center
NCT06524960
AIDANET At Home Study
Sue Brown
NCT07039617
Expansion of the T1DES Pilot to a Public Hospital
Kaiser Permanente
NCT06494722
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
University of Virginia
NCT05653518
Using Simplified Meal Boluses Versus Carbohydrate Counting in Adolescents With Hybrid Closed Loop Systems
University of Colorado, Denver
NCT06575790
Effect of C-peptide on Hypoglycemic Counterregulation
University of Cincinnati
NCT06470295
Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use
Yale University
NCT06171412
AIDANET Pediatrics
Mark D. DeBoer, MD, MSc., MCR
NCT07020936
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 27 |
| Phase 2 | 23 |
| Phase 3 | 10 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Type 1 Diabetes Trial Landscape
179 indexed Type 1 Diabetes studies · 69 recruiting (39%).
Phase mix: 19 late (III/IV) vs 50 early (I/II).
Top sponsor: University of Colorado, Denver (14 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Type 1 Diabetes?
PlainTrial tracks 179 US clinical trials for Type 1 Diabetes, of which 69 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Type 1 Diabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.