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NCT05454891 · ClinicalTrials.gov registry record · Phase 4
Extended Bolus for Meals in a Closed-loop System
A Phase 4 study of Type 1 Diabetes, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT05454891: Recruiting Phase 4 study of Type 1 Diabetes, sponsored by University of California, San Francisco.
NCT05454891 is a Phase 4 study of Type 1 Diabetes that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 30 participants, below the 767-participant average among 198 other Type 1 Diabetes trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05454891, a Phase 4 study of Type 1 Diabetes, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to evaluate whether the use of an extended bolus will improve glucose control with high-fat high protein meals using a closed-loop system. The new knowledge gained from this study may provide a method to allow for the proper administration of insulin over an extended period to mitigate the risk of prolonged hyperglycemia or early hypoglycemia.
Primary Outcome
Area under the curve between glucose trace and starting glucose (mg/dL\* min)
Conditions Studied
Interventions
- DRUG Extended bolus of insulin then standard bolus of insulin
- DRUG Standard bolus of insulin then extended bolus of insulin
Study Locations (1)
California
- University of California San Francisco - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2022-07-15 |
| Est. Completion | 2025-09-30 |
| Phase | Phase 4 |
What NCT05454891 shows while recruiting
NCT05454891 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 767-participant average among 198 other Type 1 Diabetes trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Type 1 Diabetes appearing as the primary indexed condition, and to 2 interventions - of which Extended bolus of insulin then standard bolus of insulin is the first listed.
NCT05454891 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05454891 about?
NCT05454891 is a clinical study titled "Extended Bolus for Meals in a Closed-loop System". This study aims to evaluate whether the use of an extended bolus will improve glucose control with high-fat high protein meals using a closed-loop system. The new knowledge gained from this study may provide a method to allow for the proper administration of insulin over an extended period to mitiga...
What is the current status of trial NCT05454891?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 30 participants. The study started on 2022-07-15. Estimated completion is 2025-09-30.
What conditions does trial NCT05454891 study?
This clinical trial studies the following conditions: Type 1 Diabetes.
What interventions are being tested in trial NCT05454891?
The interventions under investigation include: Extended bolus of insulin then standard bolus of insulin (DRUG), Standard bolus of insulin then extended bolus of insulin (DRUG).
Who is sponsoring clinical trial NCT05454891?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05454891 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Type 1 Diabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05454891's enrollment target sits among peer trials
30 127th of 198 higher than 68 of 198 other Type 1 Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Type 1 Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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