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2026 data Public-data reference. official source

Thyroid Cancer

Open-data reference.

48 US clinical trials · 25 currently recruiting

Active & Recent Trials

RECRUITING 999,999 participants

Integrated Cancer Repository for Cancer Research

University of Nebraska

NCT02012699

RECRUITING 2,500 participants

Studies on Tumors of the Thyroid

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00001160

RECRUITING 500 participants

Environmental Factors and Thyroid Cancer

Icahn School of Medicine at Mount Sinai

NCT05172921

RECRUITING 459 participants

Global Real World Data in Patients With Advanced Thyroid Cancer on Standard of Care and Specialized Interventions- Registry of Oncologic Outcomes With Testing and Treatment.

M.D. Anderson Cancer Center

NCT06507878

RECRUITING NA 408 participants

Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer

Georgetown University

NCT06980103

RECRUITING NA 320 participants

Improving Care for Rural Patients With Solid Tumors

University of Colorado, Denver

NCT04916990

RECRUITING Phase 1 267 participants

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Pfizer

NCT05355701

RECRUITING NA 250 participants

Hereditary Risk Factors for Thyroid Cancer

Dana-Farber Cancer Institute

NCT02747888

RECRUITING 200 participants

New MRI Biomarkers in Head and Neck Cancers

Memorial Sloan Kettering Cancer Center

NCT03483337

RECRUITING Phase 1 124 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Pfizer

NCT05538130

RECRUITING 100 participants

A Study to Collect Information About the Use of Redifferentiating Medications as a Standard Treatment for Thyroid Cancer

Memorial Sloan Kettering Cancer Center

NCT05733013

RECRUITING Phase 3 100 participants

Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer

Vanderbilt University Medical Center

NCT05999630

RECRUITING Phase 1 70 participants

SLV-154 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT06771219

RECRUITING Phase 2 62 participants

Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer

Thomas Hope

NCT06961084

RECRUITING NA 60 participants

Assessing Patient Satisfaction and Confidence After Use of Educational Video to Augment Surgical Consent for Thyroid Surgery

Thomas Jefferson University

NCT06918223

RECRUITING 50 participants

I-124 PET/CT Imaging and Dosimetry for RAI-Naïve or Refractory Thyroid Cancer

Miami Cancer Research Center

NCT06443866

RECRUITING Phase 2 45 participants

Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery

M.D. Anderson Cancer Center

NCT06959511

RECRUITING Phase 2 34 participants

Lenvatinib 24 mg/Day Versus 10 mg/Day to Treat Symptomatic or Progressive Radioactive Iodine Resistant (RAIR) Differentiated Thyroid Cancer (DTC)

Washington University School of Medicine

NCT07092514

RECRUITING Phase 2 30 participants

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03841617

RECRUITING Phase 2 30 participants

Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC

Massachusetts General Hospital

NCT05668962

RECRUITING Phase 2 30 participants

A Study of Avutometinib and Defactinib in People With Thyroid Cancer

Memorial Sloan Kettering Cancer Center

NCT06007924

RECRUITING NA 20 participants

TRAIL Study: Feasibility and Pilot

Dartmouth-Hitchcock Medical Center

NCT06220656

RECRUITING Phase 1 12 participants

XL092 and Cemiplimab in BRAF WT Thyroid Cancer

UNC Lineberger Comprehensive Cancer Center

NCT06902376

RECRUITING Phase 1 11 participants

Brodalumab in the Treatment of Immune-Related Adverse Events

Brian Henick, MD

NCT06673329

RECRUITING NA 10 participants

Personalized Treatment in Thyroid Disorders

Johns Hopkins University

NCT03517579

ACTIVE NOT RECRUITING 5,000 participants

Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial

Brigham and Women's Hospital

NCT07255482

ACTIVE NOT RECRUITING NA 603 participants

Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health

University of Alabama at Birmingham

NCT04000880

ACTIVE NOT RECRUITING 138 participants

Measuring Patient Expectations for Thyroid Surgery

Memorial Sloan Kettering Cancer Center

NCT01412762

ACTIVE NOT RECRUITING 102 participants

A Study of Optical Imaging With Light From Radiotracers in Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT03484884

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

ACTIVE NOT RECRUITING Phase 2 46 participants

Pembrolizumab With Chemotherapy for Poorly Chemo-responsive Thyroid and Salivary Gland Tumors

University of Chicago

NCT03360890

ACTIVE NOT RECRUITING Phase 2 41 participants

Evaluating the Combination of Everolimus and Sorafenib in the Treatment of Thyroid Cancer

Memorial Sloan Kettering Cancer Center

NCT01141309

ACTIVE NOT RECRUITING 39 participants

CASE 1320: RAI Uptake and Serum Prolactin in Thyroid Cancer

The Cleveland Clinic

NCT04495985

ACTIVE NOT RECRUITING Phase 2 24 participants

Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer

M.D. Anderson Cancer Center

NCT01709292

ACTIVE NOT RECRUITING Phase 2 19 participants

PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer

Memorial Sloan Kettering Cancer Center

NCT04544111

ACTIVE NOT RECRUITING Phase 2 16 participants

Study of Cemiplimab Combined With Dabrafenib and Trametinib in People With Anaplastic Thyroid Cancer

Memorial Sloan Kettering Cancer Center

NCT04238624

ACTIVE NOT RECRUITING Phase 2 12 participants

Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

Stanford University

NCT05119296

ACTIVE NOT RECRUITING Early Phase 1 11 participants

RAI Plus Immunotherapy for Recurrent/Metastatic Thyroid Cancers

Memorial Sloan Kettering Cancer Center

NCT03215095

ACTIVE NOT RECRUITING Phase 2 10 participants

Laser Ablation of Papillary Thyroid Microcarcinoma

Memorial Sloan Kettering Cancer Center

NCT04623801

ACTIVE NOT RECRUITING Phase 2 8 participants

A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer

Dana-Farber Cancer Institute

NCT02657551

ACTIVE NOT RECRUITING NA 5 participants

Study of PET Imaging With 18F-TFB in Patients With Thyroid Cancer

Memorial Sloan Kettering Cancer Center

NCT03196518

COMPLETED Phase 3 392 participants

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Trial of Lenvatinib (E7080) in 131I-Refractory Differentiated Thyroid Cancer (DTC)

Eisai

NCT01321554

COMPLETED Phase 3 330 participants

Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer

Exelixis

NCT00704730

COMPLETED 186 participants

Decision Making and Psychological Outcomes in Low-Risk Papillary Thyroid Cancer

Memorial Sloan Kettering Cancer Center

NCT03300284

COMPLETED Phase 2 100 participants

Molecular Testing to Direct Extent of Initial Thyroid Surgery

University of Pittsburgh

NCT02947035

COMPLETED 70 participants

Effect of Childhood Radioiodine Therapy on Salivary Function

Boston Children's Hospital

NCT02375451

COMPLETED Phase 2 35 participants

Study of Irofulven Plus Capecitabine in Patients With Advanced Thyroid Cancer

Eisai

NCT00124527

COMPLETED Phase 2 13 participants

Energy Metabolism in Thyroidectomized Patients

Virginia Commonwealth University

NCT04782856

Phase Distribution

PhaseTrial count
Early Phase 1 7
Phase 2 17
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Thyroid Cancer Trial Landscape

ClinicalTrials.gov lists 48 US studies indexed under Thyroid Cancer, and 25 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Thyroid Cancer shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 24 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Thyroid Cancer is led by Memorial Sloan Kettering Cancer Center with 12 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Thyroid Cancer?

PlainTrial tracks 48 US clinical trials for Thyroid Cancer, of which 25 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Thyroid Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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