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NCT06220656 · ClinicalTrials.gov registry record · NA
TRAIL Study: Feasibility and Pilot
A NA study of Thyroid Cancer and Thyroid Neoplasms, sponsored by Dartmouth-Hitchcock Medical Center.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06220656: Recruiting NA study of Thyroid Cancer and Thyroid Neoplasms, sponsored by Dartmouth-Hitchcock Medical Center.
NCT06220656 is a NA study of Thyroid Cancer and Thyroid Neoplasms that is actively recruiting participants, run by Dartmouth-Hitchcock Medical Center. The registered enrollment target is 20 participants, below the 281-participant average among 46 other Thyroid Cancer trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06220656, a NA study of Thyroid Cancer and Thyroid Neoplasms, is actively recruiting participants, sponsored by Dartmouth-Hitchcock Medical Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a pilot study to compare two ways of managing newly identified thyroid nodules that are likely to be cancerous based on ultrasound result and which under usual care would undergo immediate biopsy. The main goals of this pilot study are 1) compare anxiety at 6 months in each treatment arm using the validated instrument Anxiety-CA, 2) measure thyroid quality of life in each treatment arm Participants will be randomized to one of two groups: 1. immediate biopsy (usual care) 2. Active monitoring (serial ultrasound based monitoring and close clinical follow-up)
Primary Outcome
Rate of anxiety will be measured using Anxiety-CA instrument PROMIS-Anxiety Short form. Each question has five response options ranging in value from one to five. (1 = never experiencing a type of distressing emotion; 5 = always feeling that emotion). To find the total raw score for a short form with all questions answered, sum the values of the response to each question. For the adult PROMIS Anxiety 7a short form, a raw score of 10 converts to a T-score of 46.7 with a standard error (SE) of 2.6
Conditions Studied
Interventions
- PROCEDURE Biopsy
- PROCEDURE Active Monitoring
Study Locations (1)
New Hampshire
- Dartmouth Hitchcock Medical Center - Lebanon
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-05-01 |
| Est. Completion | 2027-06 |
| Phase | NA |
What NCT06220656 shows while recruiting
NCT06220656 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 281-participant average among 46 other Thyroid Cancer trials with a reported enrollment target (93% lower).
The record links to 3 conditions, with Thyroid Cancer appearing as the primary indexed condition, and to 2 interventions - of which Biopsy is the first listed.
NCT06220656 reports a single indexed study location in New Hampshire.
Frequently Asked Questions
What is clinical trial NCT06220656 about?
NCT06220656 is a clinical study titled "TRAIL Study: Feasibility and Pilot". This is a pilot study to compare two ways of managing newly identified thyroid nodules that are likely to be cancerous based on ultrasound result and which under usual care would undergo immediate biopsy. The main goals of this pilot study are 1) compare anxiety at 6 months in each treatment arm us...
What is the current status of trial NCT06220656?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2025-05-01. Estimated completion is 2027-06.
What conditions does trial NCT06220656 study?
This clinical trial studies the following conditions: Thyroid Cancer, Thyroid Neoplasms, Thyroid Nodule.
What interventions are being tested in trial NCT06220656?
The interventions under investigation include: Biopsy (PROCEDURE), Active Monitoring (PROCEDURE).
Who is sponsoring clinical trial NCT06220656?
This trial is sponsored by Dartmouth-Hitchcock Medical Center, which has 427 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06220656 being conducted?
This trial has 1 study location across New Hampshire. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Thyroid Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06220656's enrollment target sits among peer trials
20 36th of 46 higher than 11 of 46 other Thyroid Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Thyroid Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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