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Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC
NCT05668962 · View on ClinicalTrials.gov ↗
Study Summary
This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-refractory thyroid cancer. This research study involves the study drug selpercatinib in combination with standard of care treatments, I-131 and thyrotropin alfa (rhTSH).
Conditions Studied
Interventions
- DRUG Selpercatinib
- DRUG Sodium Iodine I-131
- DRUG rhTSH
Study Locations (6)
District of Columbia
- MedStar Washington Hospital Center — Washington D.C.
Florida
- Moffitt Cancer Center — Tampa
Massachusetts
- Massachusetts General Hospital — Boston
Michigan
- University of Michigan — Ann Arbor
Pennsylvania
- Children's Hospital of Philadelphia — Philadelphia
Texas
- MD Anderson Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2023-03-01 |
| Est. Completion | 2026-01-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05668962
The ClinicalTrials.gov registry entry for NCT05668962 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Massachusetts General Hospital, which has 1,948 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Thyroid Cancer appearing as the primary indexed condition, and to 3 interventions — of which Selpercatinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05668962 reports 6 study locations spanning 6 distinct geographic areas — top geographies include District of Columbia, Florida, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05668962 about?
NCT05668962 is a clinical study titled "Restor. I-131 Upt. + Selpercatinib in RET F-P RAI-R TC". This research is being done to determine the efficacy of selpercatinib to restore radioactive iodine (I-131 NaI) uptake and allow for I-131 treatment in people with RET fusion-positive radioiodine-refractory thyroid cancer. This research study involves the study drug selpercatinib in combination wi...
What is the current status of trial NCT05668962?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2023-03-01. Estimated completion is 2026-01-01.
What conditions does trial NCT05668962 study?
This clinical trial studies the following conditions: Thyroid Cancer, Papillary Thyroid Cancer, Unresectable Thyroid Gland Carcinoma, Thyroid Carcinoma, Follicular Thyroid Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05668962?
The interventions under investigation include: Selpercatinib (DRUG), Sodium Iodine I-131 (DRUG), rhTSH (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05668962?
This trial is sponsored by Massachusetts General Hospital, which has 1,948 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05668962 being conducted?
This trial has 6 study locations across District of Columbia, Florida, Massachusetts, Michigan, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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