Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 13 recruiting now official registry

Amblyopia clinical trials

Every US clinical trial registered for Amblyopia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

25 US clinical trials · 13 currently recruiting

The research picture

Amblyopia has 25 registered US clinical trials, 13 of them open to new participants right now — about 52% of the total.

13
recruiting participants now
52%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
9
top sponsor: Jaeb Center for Health Research

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 544 participants

A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

Jaeb Center for Health Research

NCT04378790

RECRUITING 500 participants

Clinical Data Registry of Amblyopia Patients on Luminopia Treatment

Luminopia

NCT06429280

RECRUITING Phase 3 252 participants

Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

Jaeb Center for Health Research

NCT06524882

RECRUITING Phase 3 238 participants

Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

Jaeb Center for Health Research

NCT06380517

RECRUITING NA 180 participants

Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games

Nova Southeastern University

NCT05522972

RECRUITING 150 participants

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

The Cleveland Clinic

NCT04310241

RECRUITING NA 120 participants

Binocular Amblyopia Treatment

Retina Foundation of the Southwest

NCT03288948

RECRUITING NA 68 participants

Patch-free Occlusion Therapy

Retina Foundation of the Southwest

NCT05440448

RECRUITING NA 60 participants

Noninvasive Brain Stimulation in Adult Amblyopia

Midwestern University

NCT06712849

RECRUITING NA 44 participants

Video Treatment for Amblyopia

Retina Foundation of the Southwest

NCT05439200

RECRUITING NA 30 participants

OCT Eccentric Fixation and Amblyopia in Children

State University of New York College of Optometry

NCT05714449

RECRUITING NA 30 participants

Amblyopia Treatment for Children Aged 8 to 12 Years

Retina Foundation of the Southwest

NCT07281742

RECRUITING NA 8 participants

Novel Amblyopia Treatment With Virtual Reality Games

Marjean Ku

NCT06049459

ACTIVE NOT RECRUITING NA 96 participants

Binocular iPad Sub-Study

Retina Foundation of the Southwest

NCT02365090

COMPLETED Phase 3 419 participants

Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia

Jaeb Center for Health Research

NCT00000170

COMPLETED Phase 3 268 participants

Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children

Jaeb Center for Health Research

NCT00091923

COMPLETED 227 participants

Gocheck Kids vs. Welch Allyn Spot Vision Screener

Yale University

NCT04321538

COMPLETED Phase 3 189 participants

Trial Comparing Part-time Versus Minimal-time Patching for Moderate Amblyopia

Jaeb Center for Health Research

NCT00094679

COMPLETED Phase 3 175 participants

Trial Comparing Part-time Versus Full-time Patching for Severe Amblyopia

Jaeb Center for Health Research

NCT00094744

COMPLETED Phase 3 139 participants

Levodopa for the Treatment of Residual Amblyopia

Jaeb Center for Health Research

NCT01190813

COMPLETED 92 participants

A New Approach to Vision Therapy Based on Naturalistic 3-D Computer Gaming

Barron Associates

NCT03066063

COMPLETED Phase 3 73 participants

Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old

Jaeb Center for Health Research

NCT00944710

COMPLETED 32 participants

Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner

Rebiscan

NCT01706991

COMPLETED Phase 3 20 participants

Amblyopia (Lazy Eye) Treatment Study

National Eye Institute (NEI)

NCT00001864

COMPLETED Phase 4 20 participants

Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia

Dennis Levi

NCT03109314

Phase Distribution

PhaseTrial count
Phase 3 10
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Amblyopia Trial Landscape

ClinicalTrials.gov lists 25 US studies indexed under Amblyopia, and 13 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Amblyopia shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 0 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Amblyopia is led by Jaeb Center for Health Research with 9 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Amblyopia?

PlainTrial tracks 25 US clinical trials for Amblyopia, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Amblyopia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →