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NCT07255482 · ClinicalTrials.gov registry record
Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial
A clinical trial of Thyroid Cancer and Thyroid Nodule (Benign), sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- 5,000
- Enrollment target
- 1
- Study location
NCT07255482 is a study of Thyroid Cancer and Thyroid Nodule (Benign) that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 5,000 participants, above the 173-participant average among 46 other Thyroid Cancer trials with a reported enrollment target (2790% higher). The trial reports 1 study location across 1 state.
The verdict
NCT07255482, a study of Thyroid Cancer and Thyroid Nodule (Benign), is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- 5,000 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators hypothesize that all-cause mortality in patients with an incidental thyroid nodule on PET-CT who did not have thyroid ultrasound (the exposure) within 3 months of the PET-CT is non-inferior within a 5% margin to those who have thyroid ultrasound at 7-years. That is, among patients with an incidental thyroid nodule on PET-CT, mortality is no more than 5% larger (in absolute difference) for those who do not have thyroid ultrasound compared to those who do. The investigators will also report mortality differences at landmark timeframes of 1-year, 3-years, 5-years, and 10-years. To estimate group differences in mortality, the investigators will conduct a non-inferiority emulated target trial utilizing clone-censor weighting to address potential immortal time bias introduced by the 3-month grace period. The investigators will adjust for demographic, potential confounder, and mortality risk adjustor factors. The investigators will stratify analyses based on baseline disease severity (estimated 5-year relative survival risk) and disease status (progression, lymph node involvement, other sites of metastases). All subjects will be accrued from the Mass General Brigham healthcare system, which includes two academic medical centers, a specialty head and neck hospital, and multiple community hospitals and numerous community clinics.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Thyroid Ultrasound
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5,000 participants |
| Start Date | 2025-10-15 |
| Est. Completion | 2026-03-31 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07255482
The ClinicalTrials.gov registry entry for NCT07255482 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 5,000 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 173-participant average among 46 other Thyroid Cancer trials with a reported enrollment target (2790% higher). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Thyroid Cancer appearing as the primary indexed condition, and to 1 intervention - of which Thyroid Ultrasound is the first listed.
NCT07255482 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07255482 about?
NCT07255482 is a clinical study titled "Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial". The investigators hypothesize that all-cause mortality in patients with an incidental thyroid nodule on PET-CT who did not have thyroid ultrasound (the exposure) within 3 months of the PET-CT is non-inferior within a 5% margin to those who have thyroid ultrasound at 7-years. That is, among patients ...
What is the current status of trial NCT07255482?
This trial is currently active not recruiting. The enrollment target is 5,000 participants. The study started on 2025-10-15. Estimated completion is 2026-03-31.
What conditions does trial NCT07255482 study?
This clinical trial studies the following conditions: Thyroid Cancer, Thyroid Nodule (Benign), Thyroid Nodule (Diagnosis).
What interventions are being tested in trial NCT07255482?
The interventions under investigation include: Thyroid Ultrasound (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT07255482?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07255482 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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