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ClinicalTrials.gov 38 recruiting now official registry

Small-cell Lung Cancer clinical trials

38 of 80 indexed Small-cell Lung Cancer trials are currently recruiting.

80 US clinical trials · 38 currently recruiting

Small-cell Lung Cancer is the subject of 80 registered US clinical trials on ClinicalTrials.gov, 38 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 54 in Phase 1-2 (earlier-stage). The most active sponsor is Amgen, running 5 of these trials.

The research picture

Small-cell Lung Cancer has 80 registered US clinical trials, 38 of them open to new participants right now, about 48% of the total.

38
recruiting participants now
48%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
5
top sponsor: Amgen
Phase 131Phase 223Phase 311

Active & Recent Trials

80 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 1 56 participants

Evaluation of AL3818 in Combination With Nivolumab in Solid Tumors

Sarcoma Oncology Research Center

NCT04165330

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING Phase 2 36 participants

Phase 2 Safety and Efficacy Evaluation of AL8326 in ≥2nd Line SCLC

Advenchen Pharmaceuticals

NCT05363280

ACTIVE NOT RECRUITING Phase 1 31 participants

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel After Progression on Frontline Therapy in Non-small Cell and Small Cell Lung Cancers

Washington University School of Medicine

NCT05616624

ACTIVE NOT RECRUITING Phase 2 31 participants

Study of AZD2811 + Durvalumab in ES-SCLC

AstraZeneca

NCT04745689

ACTIVE NOT RECRUITING Phase 1 25 participants

Radiotherapy and Durvalumab/Durvalumab Combo (Tremelimumab/Olaparid) for Small Cell Lung Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT03923270

ACTIVE NOT RECRUITING Phase 2 25 participants

Ipilimumab and Nivolumab in Recurrent Extensive Stage Small Cell Lung Cancer After Receiving Platinum-based Chemotherapy

Yale University

NCT03670056

ACTIVE NOT RECRUITING Phase 2 14 participants

Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC

Case Comprehensive Cancer Center

NCT04010357

COMPLETED Phase 3 491 participants

Study of Irinotecan Liposome Injection (ONIVYDE®) in Patients With Small Cell Lung Cancer

Ipsen

NCT03088813

COMPLETED Phase 3 490 participants

A Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated Extensive-Stage Small Cell Lung Cancer

Hoffmann-La Roche

NCT04256421

COMPLETED Phase 3 405 participants

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers

Alliance for Clinical Trials in Oncology

NCT02349412

COMPLETED Phase 1 215 participants

NT-I7 (Efineptakin Alfa) in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

NeoImmuneTech

NCT04332653

COMPLETED Phase 1 184 participants

Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma

Amgen

NCT00531284

COMPLETED Phase 2 133 participants

A Study of Prexasertib (LY2606368) in Participants With Extensive Stage Disease Small Cell Lung Cancer

Eli Lilly and Company

NCT02735980

COMPLETED Phase 2 107 participants

Carboplatin, Etoposide, and Atezolizumab With or Without Trilaciclib (G1T28), a CDK4/6 Inhibitor, in Extensive-Stage SCLC

G1 Therapeutics

NCT03041311

COMPLETED Phase 1 105 participants

A Study of SY 5609, a Selective CDK7 Inhibitor, in Advanced Solid Tumors

Syros Pharmaceuticals

NCT04247126

COMPLETED Phase 1 86 participants

A Phase 1/2a Study of ABT-263 in Subjects With Small Cell Lung Cancer (SCLC) or Other Non-Hematological Malignancies

AbbVie (prior sponsor, Abbott)

NCT00445198

COMPLETED Phase 2 76 participants

Study Comparing Amrubicin Versus Topotecan in Patients With Small Cell Lung Cancer Who Have Responded to Prior Therapy.

Celgene Corporation

NCT00319969

COMPLETED Phase 1 71 participants

Study of the Safety, Pharmacokinetics and Efficacy of Tinostamustine in Patients With Advanced Solid Tumors.

Mundipharma Research Limited

NCT03345485

COMPLETED Phase 2 69 participants

To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic Acid

H. Lee Moffitt Cancer Center and Research Institute

NCT00617409

COMPLETED Phase 1 59 participants

IMP4297 in Combination With Temozolomide in Patients With Advanced Solid Tumors and Small Cell Lung Cancer

Impact Therapeutics

NCT04434482

COMPLETED Phase 1 48 participants

A Study of LY3295668 Erbumine in Participants With Extensive-stage Small-Cell Lung Cancer

Eli Lilly and Company

NCT03898791

COMPLETED 40 participants

Comprehensive Genomic Analysis in Tissue and Blood Samples From Young Patients With Lung Cancer

University of Southern California

NCT02273336

COMPLETED Phase 2 38 participants

Higher Dose Weekly Topotecan In The Treatment Of Patients With Extensive Stage Small-Cell Lung Cancer

SCRI Development Innovations

NCT00294190

COMPLETED Phase 2 33 participants

Combination Rucaparib With Nivolumab in Small Cell Lung Carcinoma

Zhonglin Hao

NCT03958045

COMPLETED Phase 1 30 participants

Bendamustine With Irinotecan Followed by Etoposide/Carboplatin for Patients With Extensive Stage Small Cell Lung Cancer

University of Alabama at Birmingham

NCT00856830

COMPLETED Phase 1 30 participants

A Study of Intravenous XMT-1001 in Patients With Advanced Solid Tumors

Mersana Therapeutics

NCT00455052

COMPLETED NA 20 participants

Hippocampal Prophylactic Cranial Irradiation for Small Cell Lung Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01797159

COMPLETED Phase 2 20 participants

Gleevec Maintenance Therapy After Induction Irinotecan and Cisplatin in Patients With C-Kit Positive Extensive SCLC

University of Michigan Rogel Cancer Center

NCT00156286

COMPLETED 12 participants

TS Overexpression in SCLC: Mechanism and Therapeutic Targeting

Wake Forest University Health Sciences

NCT03741829

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Phase Distribution

PhaseTrial count
Phase 1 31
Phase 2 23
Phase 3 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Small-cell Lung Cancer Trial Landscape

80 indexed Small-cell Lung Cancer studies · 38 recruiting (48%).

Phase mix: 11 late (III/IV) vs 54 early (I/II).

Top sponsor: Amgen (5 trials), 9 others listed. 30 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Small-cell Lung Cancer?

PlainTrial tracks 80 US clinical trials for Small-cell Lung Cancer, of which 38 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Small-cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.