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ClinicalTrials.gov 38 recruiting now official registry

Small-cell Lung Cancer clinical trials

38 of 80 indexed Small-cell Lung Cancer trials are currently recruiting.

80 US clinical trials · 38 currently recruiting

Small-cell Lung Cancer is the subject of 80 registered US clinical trials on ClinicalTrials.gov, 38 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 54 in Phase 1-2 (earlier-stage). The most active sponsor is Amgen, running 5 of these trials.

The research picture

Small-cell Lung Cancer has 80 registered US clinical trials, 38 of them open to new participants right now, about 48% of the total.

38
recruiting participants now
48%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
5
top sponsor: Amgen
Phase 131Phase 223Phase 311

Active & Recent Trials

80 total, page 1 of 2

RECRUITING 2,000 participants

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

National Cancer Institute (NCI)

NCT02146170

RECRUITING 1,650 participants

A Multicenter Cancer Biospecimen Collection Study

Cofactor Genomics

NCT04510129

RECRUITING Phase 3 540 participants

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

Daiichi Sankyo

NCT06203210

RECRUITING Phase 3 480 participants

A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

Zai Lab (Shanghai) Co.

NCT07218146

RECRUITING Phase 1 470 participants

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

SystImmune

NCT05983432

RECRUITING Phase 3 400 participants

Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)

Amgen

NCT06117774

RECRUITING Phase 1 386 participants

Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors

Conjupro Biotherapeutics

NCT07424547

RECRUITING Phase 3 330 participants

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

Amgen

NCT07005128

RECRUITING Phase 2 280 participants

Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

Fox Chase Cancer Center

NCT05800587

RECRUITING Phase 1 262 participants

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

Merck Sharp & Dohme

NCT06780137

RECRUITING Phase 1 258 participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

BeiGene

NCT06257264

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 1 208 participants

A Study of IDE849 in Patients With DLL3 Expressing Tumors Including Small Cell Lung Cancer

IDEAYA Biosciences

NCT07174583

RECRUITING Phase 1 200 participants

Study of Tarlatamab in Combination With YL201 With or Without Anti-programmed Death Ligand 1 (PD-L1) in Participants With Extensive Stage (ES) Small Cell Lung Cancer (SCLC)

Amgen

NCT06898957

RECRUITING Phase 2 180 participants

A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer

AbbVie

NCT07155174

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING 111 participants

Genomic and Methylation Markers in SCLC and LCNEC for Chemo-Immunotherapy Resistance Prediction (STRATUS)

Oncology Center of Biochemical Education And Research

NCT06717243

RECRUITING NA 100 participants

LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)

University of California, Davis

NCT06103682

RECRUITING Phase 2 80 participants

A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer

Puma Biotechnology

NCT06095505

RECRUITING NA 70 participants

A Study of Hospital-at-Home for People Receiving Tarlatamab

Memorial Sloan Kettering Cancer Center

NCT06957314

RECRUITING Phase 1 67 participants

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

Novelty Nobility

NCT06805825

RECRUITING Phase 2 62 participants

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Memorial Sloan Kettering Cancer Center

NCT05419076

RECRUITING Phase 1 53 participants

PET/CT Imaging of Small Cell Lung Cancer Using 89Zr-DFO-SC16.56

Memorial Sloan Kettering Cancer Center

NCT04199741

RECRUITING 50 participants

Tempus Sculptor Study: Small Cell Lung Cancer (SCLC) Observational Study

Tempus AI

NCT05257551

RECRUITING Phase 2 49 participants

Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)

University of Chicago

NCT05068232

RECRUITING Phase 1 44 participants

ST-001 nanoFenretinide in Relapsed/ Refractory Small Cell Lung Cancer

SciTech Development

NCT06922539

RECRUITING Phase 1 42 participants

Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)

Washington University School of Medicine

NCT07155200

RECRUITING Phase 2 38 participants

Phase 2 Study of Fingolimod in Lung Cancers

Medical University of South Carolina

NCT06424067

RECRUITING Phase 2 37 participants

Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer

University of Maryland, Baltimore

NCT05450965

RECRUITING Phase 1 36 participants

Chiauranib for Advanced Solid Malignant Tumors and Relapsed/Refractory SCLC.

Chipscreen Biosciences

NCT05271292

RECRUITING 30 participants

Small Cell Lung Cancer Community Engagement to Eliminate Research Discepancies

Addario Lung Cancer Medical Institute

NCT06486428

RECRUITING NA 30 participants

Prospective Study of Intensity-Modulated Proton Therapy (IMPT) for Small Cell Lung Cancer

Emory University

NCT04342429

RECRUITING Phase 2 30 participants

Study of Trilaciclib and Lurbinectidin

UNC Lineberger Comprehensive Cancer Center

NCT05578326

RECRUITING Phase 1 30 participants

A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer

Suzhou Zelgen Biopharmaceuticals Co.

NCT06592638

RECRUITING 30 participants

Rapid Autopsy Protocol for Patients With Small Cell Lung Cancer

Indiana University

NCT05889546

RECRUITING 20 participants

7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)

University of Missouri-Columbia

NCT07175077

RECRUITING Phase 1 10 participants

Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

Nerviano Medical Sciences

NCT06931626

ACTIVE NOT RECRUITING Phase 1 1,410 participants

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Klus Pharma

NCT04152499

ACTIVE NOT RECRUITING Phase 1 733 participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

OncoC4

NCT04140526

ACTIVE NOT RECRUITING Phase 3 730 participants

Study of Durvalumab + Tremelimumab, Durvalumab, and Placebo in Limited Stage Small-Cell Lung Cancer in Patients Who Have Not Progressed Following Concurrent Chemoradiation Therapy

AstraZeneca

NCT03703297

ACTIVE NOT RECRUITING Phase 3 672 participants

Placebo-controlled, Study of Concurrent Chemoradiation Therapy With Pembrolizumab Followed by Pembrolizumab and Olaparib in Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK 7339-013/KEYLYNK-013)

Merck Sharp & Dohme

NCT04624204

ACTIVE NOT RECRUITING Phase 3 660 participants

A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer

Hoffmann-La Roche

NCT05091567

ACTIVE NOT RECRUITING Phase 2 600 participants

Pharmacogenomics ANDA SNP Clinical Study - Etoposide and Single Nucleotide Polymorphisms

Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair

NCT01064466

ACTIVE NOT RECRUITING Phase 3 563 participants

Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab

Amgen

NCT06211036

ACTIVE NOT RECRUITING Phase 1 232 participants

A Study in Participants With Advanced Cancers Associated With Expression of DLL3 (MK-6070-001/HPN328-4001)

Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT04471727

ACTIVE NOT RECRUITING Phase 2 154 participants

PF-07104091 as a Single Agent and in Combination Therapy

Pfizer

NCT04553133

ACTIVE NOT RECRUITING Phase 2 110 participants

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

BioNTech SE

NCT06449209

ACTIVE NOT RECRUITING NA 100 participants

Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases

Dana-Farber Cancer Institute

NCT03391362

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

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Phase Distribution

PhaseTrial count
Phase 1 31
Phase 2 23
Phase 3 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Small-cell Lung Cancer Trial Landscape

80 indexed Small-cell Lung Cancer studies · 38 recruiting (48%).

Phase mix: 11 late (III/IV) vs 54 early (I/II).

Top sponsor: Amgen (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Small-cell Lung Cancer?

PlainTrial tracks 80 US clinical trials for Small-cell Lung Cancer, of which 38 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Small-cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.