Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

IMP4297 in Combination With Temozolomide in Patients With Advanced Solid Tumors and Small Cell Lung Cancer

NCT04434482 · View on ClinicalTrials.gov ↗

Study Summary

This is an open-label, multi-center, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, PK characteristics and anti-tumor activity of PARP inhibitor IMP4297 and temozolomide combination therapy in patients with advanced solid tumors and with ES-SCLC who develops disease progression after 1L platinum-based regimen.

Interventions

  • DRUG IMP4297(senaparib)

Study Locations (20)

Other

  • Beijing Cancer Hospital — Beijing
  • Jilin Cancer Hospital — Jilin
  • Fudan University Shanghai Cancer Center — Shanghai
  • Hubei Cancer Hospital — Wuhan
  • Chungbuk National University Hospital — Cheongju-si
  • The Catholic university of Korea, st. Vincent's Hospital — Gyeonggi-do
  • Yonsei university health system, Severance Hospital — Seoul
  • Asan Medical Center — Seoul
  • China Medical University Hospital — Taichung
  • National Cheng Kung University Hospital — Tainan
  • Chi Mei Medical Center — Tainan
  • National Taiwan University Hospital — Taipei

New South Wales

  • Border Medical Oncology — Albury
  • Blacktown Hospital — Blacktown
  • Orange Hospital — Orange

Ohio

  • Gabrail Cancer Researh Center — Canton
  • Mark H. Zangmeister Center — Columbus

Illinois

  • GenHarp Clinical Solutions — Evergreen Park

Tennessee

  • Sarah Cannon Research Institute - Tennessee Oncology — Tennessee City

Victoria

  • Peninsula Health Frankston Hospital — Frankston

Trial Details

FieldValue
Enrollment Target 59 participants
Start Date 2020-08-07
Est. Completion 2024-04-29
Phase Phase 1

Sponsor

Impact Therapeutics

2 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04434482

The ClinicalTrials.gov registry entry for NCT04434482 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Impact Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Small Cell Lung Cancer appearing as the primary indexed condition, and to 1 intervention — of which IMP4297(senaparib) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04434482 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Other, New South Wales, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04434482 about?

NCT04434482 is a clinical study titled "IMP4297 in Combination With Temozolomide in Patients With Advanced Solid Tumors and Small Cell Lung Cancer". This is an open-label, multi-center, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, PK characteristics and anti-tumor activity of PARP inhibitor IMP4297 and temozolomide combination therapy in patients with advanced solid tumors and with ES-SCLC who develops d...

What is the current status of trial NCT04434482?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 59 participants. The study started on 2020-08-07. Estimated completion is 2024-04-29.

What conditions does trial NCT04434482 study?

This clinical trial studies the following conditions: Small Cell Lung Cancer, Advanced Solid Tumours. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04434482?

The interventions under investigation include: IMP4297(senaparib) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04434482?

This trial is sponsored by Impact Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04434482 being conducted?

This trial has 20 study locations across Illinois, Ohio, Tennessee, New South Wales, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial