Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

NCT07005128 · View on ClinicalTrials.gov ↗

Study Summary

The main objective of the study is to compare the efficacy of tarlatamab in combination with durvalumab, carboplatin and etoposide to the combination of durvalumab, carboplatin and etoposide on prolonging overall survival (OS).

Interventions

  • DRUG Carboplatin
  • DRUG Etoposide
  • DRUG Durvalumab
  • DRUG Tarlatamab

Study Locations (20)

California

  • University of California Los Angeles — Santa Monica
  • Presbyterian Intercommunity Hospital Health Whitter Hospital — Whittier

Minnesota

  • Allina Health System dba Allina Health Cancer Institute — Minneapolis
  • Mayo Clinic — Rochester

Tennessee

  • Baptist Cancer Center — Memphis
  • United States Oncology Regulatory Affairs Corporate Office — Nashville

Texas

  • US Oncology Research Investigational Products Center — Irving
  • Texas Oncology Northeast Texas — Tyler

Buenos Aires

  • Cemic — Ciudad Autonoma de Buenos Aires
  • Hospital Universitario Austral — Pilar

Arkansas

  • Saint Bernards Medical Center — Jonesboro

Connecticut

  • Yale New Haven Hospital — New Haven

Illinois

  • University of Illinois Chicago — Chicago

Trial Details

FieldValue
Enrollment Target 330 participants
Start Date 2025-08-18
Est. Completion 2029-07-15
Phase Phase 3

Sponsor

Amgen

266 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07005128

The ClinicalTrials.gov registry entry for NCT07005128 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 330 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Small-cell Lung Cancer appearing as the primary indexed condition, and to 4 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07005128 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Minnesota, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07005128 about?

NCT07005128 is a clinical study titled "A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)". The main objective of the study is to compare the efficacy of tarlatamab in combination with durvalumab, carboplatin and etoposide to the combination of durvalumab, carboplatin and etoposide on prolonging overall survival (OS).

What is the current status of trial NCT07005128?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 330 participants. The study started on 2025-08-18. Estimated completion is 2029-07-15.

What conditions does trial NCT07005128 study?

This clinical trial studies the following conditions: Small-cell Lung Cancer, Extensive Stage Small-cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07005128?

The interventions under investigation include: Carboplatin (DRUG), Etoposide (DRUG), Durvalumab (DRUG), Tarlatamab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07005128?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07005128 being conducted?

This trial has 20 study locations across Arkansas, California, Connecticut, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial