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RECRUITING Phase 3

Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)

NCT06117774 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this study is to compare the efficacy of tarlatamab with placebo as assessed by progression free survival (PFS) based on blinded independent central review (BCIR) per response evaluation criteria in solid tumors v1.1 (RECIST 1.1) and on prolonging overall survival (OS).

Interventions

  • DRUG Placebo
  • DRUG Tarlatamab

Study Locations (20)

New York

  • New York University Grossman School of Medicine and New York University Langone Hospitals — New York
  • Perlmutter Cancer Center at New York University Langone Hospital - Long Island — New York
  • Montefiore Einstein Center for Cancer Care — The Bronx

California

  • Valkyrie Clinical Trials — Los Angeles
  • University of California Los Angeles — Santa Monica

Pennsylvania

  • Lehigh Valley Health Network — Allentown
  • Spokenword Clinical Trials — Easton

Texas

  • Renovatio Clinical — The Woodlands
  • US Oncology Research Investigational Products Center — The Woodlands

Virginia

  • University of Virginia Health System — Charlottesville
  • Virginia Cancer Specialists, PC — Fairfax

Buenos Aires

  • Fundacion Respirar — Ciudad Autonoma de Buenos Aires
  • Hospital Italiano de La Plata — La Plata

Connecticut

  • Yale New Haven Hospital — New Haven

Florida

  • Boca Raton Clinical Research Global South Florida — Plantation

Trial Details

FieldValue
Enrollment Target 400 participants
Start Date 2024-02-20
Est. Completion 2030-05-29
Phase Phase 3

Sponsor

Amgen

266 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06117774

The ClinicalTrials.gov registry entry for NCT06117774 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 400 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06117774 reports 20 study locations spanning 13 distinct geographic areas — top geographies include New York, California, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06117774 about?

NCT06117774 is a clinical study titled "Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)". The primary objective of this study is to compare the efficacy of tarlatamab with placebo as assessed by progression free survival (PFS) based on blinded independent central review (BCIR) per response evaluation criteria in solid tumors v1.1 (RECIST 1.1) and on prolonging overall survival (OS).

What is the current status of trial NCT06117774?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 400 participants. The study started on 2024-02-20. Estimated completion is 2030-05-29.

What conditions does trial NCT06117774 study?

This clinical trial studies the following conditions: Small Cell Lung Cancer, Limited Stage Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06117774?

The interventions under investigation include: Placebo (DRUG), Tarlatamab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06117774?

This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06117774 being conducted?

This trial has 20 study locations across California, Connecticut, Florida, Kentucky, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial