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Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab
NCT06211036 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective of this study is to compare the efficacy of tarlatamab plus durvalumab with durvalumab alone on prolonging overall survival (OS).
Conditions Studied
Interventions
- DRUG Durvalumab
- DRUG Tarlatamab
Study Locations (20)
Georgia
- University Cancer and Blood Center LLC — Athens
- Emory University — Atlanta
- Northeast Georgia Medical Center — Gainesville
Minnesota
- Mayo Clinic — Rochester
- Allina Health System dba Allina Health Cancer Institute — Saint Paul
New Jersey
- Astera Cancer Care — East Brunswick
- Rutgers Cancer Institute of New Jersey — New Brunswick
North Carolina
- Duke University — Durham
- Wake Forest University Health Sciences — Winston-Salem
Alabama
- Infirmary Cancer Center — Mobile
California
- University of Southern California — Los Angeles
Connecticut
- Yale New Haven Hospital — New Haven
Illinois
- University of Illinois Chicago — Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 563 participants |
| Start Date | 2024-06-05 |
| Est. Completion | 2028-09-30 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06211036
The ClinicalTrials.gov registry entry for NCT06211036 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 563 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amgen, which has 266 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Small-Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Durvalumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06211036 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Georgia, Minnesota, New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06211036 about?
NCT06211036 is a clinical study titled "Study Comparing Tarlatamab and Durvalumab Versus Durvalumab Alone in First-Line Extensive-Stage Small-Cell Lung Cancer (ES-SCLC) Following Platinum, Etoposide and Durvalumab". The primary objective of this study is to compare the efficacy of tarlatamab plus durvalumab with durvalumab alone on prolonging overall survival (OS).
What is the current status of trial NCT06211036?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 563 participants. The study started on 2024-06-05. Estimated completion is 2028-09-30.
What conditions does trial NCT06211036 study?
This clinical trial studies the following conditions: Small-Cell Lung Cancer, Extensive-Stage Small-Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06211036?
The interventions under investigation include: Durvalumab (DRUG), Tarlatamab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06211036?
This trial is sponsored by Amgen, which has 266 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06211036 being conducted?
This trial has 20 study locations across Alabama, California, Connecticut, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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