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NCT04438187 · ClinicalTrials.gov registry record · NA
Trial of Antimicrobial Restraint in Presumed Pneumonia
A NA study of Sepsis and Healthcare-Associated Pneumonia, sponsored by University of Kansas Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 186
- Enrollment target
- 1
- Study location
NCT04438187: Completed NA study of Sepsis and Healthcare-Associated Pneumonia, sponsored by University of Kansas Medical Center.
NCT04438187 is a NA study of Sepsis and Healthcare-Associated Pneumonia that has completed, run by University of Kansas Medical Center. The registered enrollment target is 186 participants, below the 6,563-participant average among 90 other Sepsis trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04438187, a NA study of Sepsis and Healthcare-Associated Pneumonia, has completed, sponsored by University of Kansas Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 186 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this cluster-randomized crossover study is to determine the effect of delaying antimicrobial initiation until objective microbiologic data is obtained in patients with presumed ICU-acquired pneumonia without septic shock.
Primary Outcome
as a pilot study the primary outcome will be protocol adherence as defined by using the criteria below: Aggressive Protocol: * Failure to send appropriate culture before initiation of antimicrobials in the absence of septic shock * Failure to stop antimicrobials in the absence of pneumonia or other documented infection after 72 hours. Conservative Protocol: * Failure to send appropriate culture * Initiation of antimicrobials (in the absence of septic shock, new onset or worsening organ dysfu
Conditions Studied
Interventions
- OTHER antimicrobial initiation
Study Locations (1)
Kansas
- KU Medical Center - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 186 participants |
| Start Date | 2021-02-01 |
| Est. Completion | 2022-06-30 |
| Phase | NA |
What the finished NCT04438187 record still lists
NCT04438187 is an interventional study that assigns participants to a tested intervention. The registered 186 participants enrollment target is mid-sized for trials with a published cap, below the 6,563-participant average among 90 other Sepsis trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Sepsis appearing as the primary indexed condition, and to 1 intervention - of which antimicrobial initiation is the first listed.
NCT04438187 reports a single indexed study location in Kansas.
Frequently Asked Questions
What is clinical trial NCT04438187 about?
NCT04438187 is a clinical study titled "Trial of Antimicrobial Restraint in Presumed Pneumonia". The objective of this cluster-randomized crossover study is to determine the effect of delaying antimicrobial initiation until objective microbiologic data is obtained in patients with presumed ICU-acquired pneumonia without septic shock.
What is the current status of trial NCT04438187?
This trial is currently completed. It is a NA study. The enrollment target is 186 participants. The study started on 2021-02-01. Estimated completion is 2022-06-30.
What conditions does trial NCT04438187 study?
This clinical trial studies the following conditions: Sepsis, Healthcare-Associated Pneumonia.
What interventions are being tested in trial NCT04438187?
The interventions under investigation include: antimicrobial initiation (OTHER).
Who is sponsoring clinical trial NCT04438187?
This trial is sponsored by University of Kansas Medical Center, which has 408 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04438187 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sepsis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04438187's enrollment target sits among peer trials
186 46th of 90 higher than 45 of 90 other Sepsis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sepsis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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