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NCT01889264 · ClinicalTrials.gov registry record
Methionine Metabolism in Enterally Fed Pediatric Sepsis
A clinical trial of Critical Illness and Sepsis, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- 45
- Enrollment target
- 1
- Study location
NCT01889264: Completed study of Critical Illness and Sepsis, sponsored by The Cleveland Clinic.
NCT01889264 is a study of Critical Illness and Sepsis that has completed, run by The Cleveland Clinic. The registered enrollment target is 45 participants, below the 3,138-participant average among 91 other Critical Illness trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01889264, a study of Critical Illness and Sepsis, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- 45 participants
- Enrollment target
- 1
- Study location
Study Summary
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis is decreased. The metabolism of sulfur amino acids through the splanchnic area and specifically methionine and cysteine have not been investigated in critically ill septic children, despite that sulfur amino acids have important roles in thiol, antioxidant and epigenetic reactions. Methionine metabolism in sick children will be influenced by its rate of utilization through different pathways. Our study aims to investigate the metabolism of methionine and cysteine when both amino acids are given by the enteral route in critically ill septic children. The investigators are focused on the rates of transmethylation, remethylation and transsulfuration in critically ill septic children, and if the current standard nutrition maintains methionine nutritional balance and functional requirements in critically ill children fed by the enteral route.
Primary Outcome
Rates of transmethylation, remethylation and transsulfuration and erythrocyte GSH synthesis when nutrients are given by the enteral route in pediatric critically ill patients.
Conditions Studied
Interventions
- OTHER Observational
Study Locations (1)
Ohio
- Cleveland Clinic - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2011-12 |
| Est. Completion | 2016-10 |
What the finished NCT01889264 record still lists
NCT01889264 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 3,138-participant average among 91 other Critical Illness trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Critical Illness appearing as the primary indexed condition, and to 1 intervention - of which Observational is the first listed.
NCT01889264 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT01889264 about?
NCT01889264 is a clinical study titled "Methionine Metabolism in Enterally Fed Pediatric Sepsis". Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis is decreased. The metabolism of sulfur amino acids through the splanch...
What is the current status of trial NCT01889264?
This trial is currently completed. The enrollment target is 45 participants. The study started on 2011-12. Estimated completion is 2016-10.
What conditions does trial NCT01889264 study?
This clinical trial studies the following conditions: Critical Illness, Sepsis.
What interventions are being tested in trial NCT01889264?
The interventions under investigation include: Observational (OTHER).
Who is sponsoring clinical trial NCT01889264?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01889264 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01889264's enrollment target sits among peer trials
45 79th of 91 higher than 13 of 91 other Critical Illness trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Critical Illness trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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