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NCT00113152 · ClinicalTrials.gov registry record
Heart Disease in Sickle Cell Anemia
A clinical trial of Pulmonary Hypertension and Sickle Cell Anemia, sponsored by National Institutes of Health Clinical Center (CC).
- Completed
- Registry status
- 120
- Enrollment target
- 2
- Study locations
NCT00113152 is a study of Pulmonary Hypertension and Sickle Cell Anemia that has completed, run by National Institutes of Health Clinical Center (CC). The registered enrollment target is 120 participants, below the 612-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (80% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT00113152, a study of Pulmonary Hypertension and Sickle Cell Anemia, has completed, sponsored by National Institutes of Health Clinical Center (CC).
- COMPLETED
- Registry status
- 120 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study will explore what may cause people with sickle cell anemia to have heart problems and an increased risk of sudden death. People 18 years of age and older with sickle cell anemia may be eligible for this study. Candidates are screened with a medical history and physical examination, electrocardiogram (EKG), echocardiogram (heart ultrasound), and blood tests. Participants undergo the following tests and procedures: * Holter monitoring: The patient wears a small, battery-operated device to record heart rate and rhythm over 24 to 48 hours. * QRST surface mapping: An EKG using 64 electrodes is done at rest and during exercise to provide a detailed look at the heart and its conduction system. * Chest x-rays are taken to examine the lungs. * Bicycle exercise echocardiography test: Blood pressure, pulse, heart rhythm and oxygen use are monitored while the patient exercises on a stationary bicycle. Ultrasound pictures are also obtained during the exercise. * Echocardiogram: A heart ultrasound is done to check how well the heart is pumping blood. * Pulmonary artery catheterization: A catheter (plastic tube) is inserted into a vein and advanced to the chambers of the heart, through the heart valve and into the lung artery. The pressures in the heart and lung blood vessels are measured while the patient is resting and during exercise, with the bed tilted up and down, and after giving 500 mls of fluid into a vein. * Blood tests are done to measure a hormone called brain natriuretic peptide, which can increase with the development of heart failure, and nitrite, a substance that can affect blood vessel dilation. Some blood is stored to test for inflammatory markers and for possible future gene and protein analysis. * Cardiac magnetic resonance imaging (cMRI): The patient lies in a donut-shaped magnet while pictures of the heart are obtained using a magnetic field and radio waves. Earplugs are worn to muffle the loud sounds that occur with electrical switching of the
Conditions Studied
Study Locations (2)
Maryland
- Suburban Hospital - Bethesda
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2005-06-02 |
| Est. Completion | 2007-10-02 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00113152
The ClinicalTrials.gov registry entry for NCT00113152 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 612-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (80% lower). The listed sponsor is National Institutes of Health Clinical Center (CC), which has 338 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Pulmonary Hypertension appearing as the primary indexed condition, and to 0 interventions.
NCT00113152 reports 2 study locations spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00113152 about?
NCT00113152 is a clinical study titled "Heart Disease in Sickle Cell Anemia". This study will explore what may cause people with sickle cell anemia to have heart problems and an increased risk of sudden death. People 18 years of age and older with sickle cell anemia may be eligible for this study. Candidates are screened with a medical history and physical examination, elect...
What is the current status of trial NCT00113152?
This trial is currently completed. The enrollment target is 120 participants. The study started on 2005-06-02. Estimated completion is 2007-10-02.
What conditions does trial NCT00113152 study?
This clinical trial studies the following conditions: Pulmonary Hypertension, Sickle Cell Anemia.
Who is sponsoring clinical trial NCT00113152?
This trial is sponsored by National Institutes of Health Clinical Center (CC), which has 338 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00113152 being conducted?
This trial has 2 study locations across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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