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NCT00675051 · ClinicalTrials.gov registry record
Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension
A clinical trial of Pulmonary Hypertension, sponsored by University of California, San Francisco.
- Completed
- Registry status
- 20
- Enrollment target
- 1
- Study location
NCT00675051: Completed study of Pulmonary Hypertension, sponsored by University of California, San Francisco.
NCT00675051 is a study of Pulmonary Hypertension that has completed, run by University of California, San Francisco. The registered enrollment target is 20 participants, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00675051, a study of Pulmonary Hypertension, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
Pulmonary hypertension is a progressive and life threatening condition. It is characterized by severe remodeling of the pulmonary vessel wall, obstructive plexiform lesions, multi-focal thrombosis, and enhanced vasoconstriction. All of these characteristics contribute to increased pulmonary vascular resistance. Circulating endothelial microparticles (EMPs) play an integral role in the pathogenesis and perpetuation of pulmonary hypertension. Levels of EMPs are considered a reliable biological parameter of endothelial injury. We propose to assess the evolution of both circulating and pulmonary venous EMPs in patients with PH. Assessments will be made before and after initiation of Endothelin-1 (ET-1) Receptor blocker therapy, and correlated to their patterns with the changes in mean PAP, the 6 Minutes Walking Distance test, and circulating Endothelin-1 values. Measurements of the endothelial microparticle circulating levels (assessed by flow cytometry methods) will be made before, 1 month and 3 months after initiation of therapy.
Conditions Studied
Study Locations (1)
California
- University of California - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2008-03 |
| Est. Completion | 2009-02 |
What the finished NCT00675051 record still lists
NCT00675051 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Pulmonary Hypertension appearing as the primary indexed condition, and to 0 interventions.
NCT00675051 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00675051 about?
NCT00675051 is a clinical study titled "Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension". Pulmonary hypertension is a progressive and life threatening condition. It is characterized by severe remodeling of the pulmonary vessel wall, obstructive plexiform lesions, multi-focal thrombosis, and enhanced vasoconstriction. All of these characteristics contribute to increased pulmonary vascular...
What is the current status of trial NCT00675051?
This trial is currently completed. The enrollment target is 20 participants. The study started on 2008-03. Estimated completion is 2009-02.
What conditions does trial NCT00675051 study?
This clinical trial studies the following conditions: Pulmonary Hypertension.
Who is sponsoring clinical trial NCT00675051?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00675051 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pulmonary Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00675051's enrollment target sits among peer trials
20 58th of 72 higher than 11 of 72 other Pulmonary Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pulmonary Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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