Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00432978 · ClinicalTrials.gov registry record · Phase 1
Effect of Bosentan on Exercise Capacity at High Altitude
A Phase 1 study of Pulmonary Hypertension and Altitude, sponsored by VA Loma Linda Health Care System.
- Completed
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT00432978: Completed Phase 1 study of Pulmonary Hypertension and Altitude, sponsored by VA Loma Linda Health Care System.
NCT00432978 is a Phase 1 study of Pulmonary Hypertension and Altitude that has completed, run by VA Loma Linda Health Care System. The registered enrollment target is 20 participants, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00432978, a Phase 1 study of Pulmonary Hypertension and Altitude, has completed, sponsored by VA Loma Linda Health Care System.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.
Conditions Studied
Interventions
- DRUG Bosentan administration
Study Locations (1)
California
- VA Loma Linda Healthcare System - Loma Linda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2006-07 |
| Est. Completion | 2007-02 |
| Phase | Phase 1 |
What the finished NCT00432978 record still lists
NCT00432978 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 613-participant average among 72 other Pulmonary Hypertension trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Pulmonary Hypertension appearing as the primary indexed condition, and to 1 intervention - of which Bosentan administration is the first listed.
NCT00432978 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00432978 about?
NCT00432978 is a clinical study titled "Effect of Bosentan on Exercise Capacity at High Altitude". This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.
What is the current status of trial NCT00432978?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2006-07. Estimated completion is 2007-02.
What conditions does trial NCT00432978 study?
This clinical trial studies the following conditions: Pulmonary Hypertension, Altitude.
What interventions are being tested in trial NCT00432978?
The interventions under investigation include: Bosentan administration (DRUG).
Who is sponsoring clinical trial NCT00432978?
This trial is sponsored by VA Loma Linda Health Care System, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00432978 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pulmonary Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00432978's enrollment target sits among peer trials
20 58th of 72 higher than 11 of 72 other Pulmonary Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pulmonary Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
RECRUITING · Phase 1
-
Feasibility of Semaglutide in Advanced Lung Disease
RECRUITING · Phase 1
-
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
RECRUITING · Phase 1
-
Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary Hypertension
COMPLETED · Phase 1
-
Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary Hypertension
COMPLETED · Phase 1
-
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
COMPLETED · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00573339 · 20 participants
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing
- NCT00692939 · 20 participants · Phase 1
Autologous Stem Cell Transplantation for Crohn's Disease
- NCT00967785 · 20 participants · Phase 1
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
- NCT01406691 · 20 participants · Phase 4
Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia