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ClinicalTrials.gov 77 recruiting now official registry

PTSD clinical trials

77 of 155 indexed PTSD trials are currently recruiting.

155 US clinical trials · 77 currently recruiting

PTSD is the subject of 155 registered US clinical trials on ClinicalTrials.gov, 77 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 29 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 28 of these trials.

The research picture

PTSD has 155 registered US clinical trials, 77 of them open to new participants right now, about 50% of the total.

77
recruiting participants now
50%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
28
top sponsor: VA Office of Research and Development
Phase 17Phase 222Phase 35Phase 45

Active & Recent Trials

155 total, page 3 of 4

COMPLETED NA 171 participants

Web and Shared Decision Making for Reserve/National Guard Women's PTSD Care

VA Office of Research and Development

NCT01710306

COMPLETED 168 participants

Key Dimensions of PTSD and ED

University of California, Los Angeles

NCT03778307

COMPLETED Phase 2 168 participants

Integrated Alcohol Disorder and PTSD Treatment

VA Office of Research and Development

NCT01601067

COMPLETED Phase 2 159 participants

Open Label Extension Safety and Efficacy Study of TNX-102 SL Tablets in Military Related PTSD and Related Conditions

Tonix Pharmaceuticals

NCT02421679

COMPLETED NA 157 participants

Improving Treatment Outcomes for Suicidal Veterans With PTSD

Ohio State University

NCT04690582

COMPLETED NA 134 participants

Effectiveness of Trauma Management Therapy and Prolonged Exposure Therapy

University of Central Florida

NCT04549493

COMPLETED NA 129 participants

Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs

VA Office of Research and Development

NCT01357577

COMPLETED NA 128 participants

Implementation of Prolonged Exposure in the Military

University of Pennsylvania

NCT02982538

COMPLETED NA 112 participants

The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk

Duke University

NCT02736929

COMPLETED Phase 2 108 participants

Women Overcoming and Managing Adversity Now (WOMAN) Study

UConn Health

NCT01324765

COMPLETED Phase 3 101 participants

Divalproex Sodium in the Treatment of PTSD (Post-Traumatic Stress Disorder)

VA Office of Research and Development

NCT00108576

COMPLETED NA 98 participants

Study of PTSD in Military Veterans Who Have Suffered Traumatic Brain Injuries

Carrick Institute for Graduate Studies

NCT02003352

COMPLETED Phase 3 93 participants

A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD

Tonix Pharmaceuticals

NCT03508700

COMPLETED NA 90 participants

A Non-Pharmacological Method for Enhancing Sleep in PTSD

University of Arizona

NCT02370173

COMPLETED NA 84 participants

Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians

University of New Mexi

NCT02124694

COMPLETED NA 76 participants

Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD

VA Office of Research and Development

NCT02641496

COMPLETED NA 69 participants

PTSD Treatment for Incarcerated Men and Women: NIMH

University of Wisconsin, Madison

NCT05168267

COMPLETED Phase 3 64 participants

Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder

Toronto Metropolitan University

NCT02336971

COMPLETED NA 62 participants

Effect of tDCS Timing on Safety Memory in PTSD

Butler Hospital

NCT04152772

COMPLETED NA 60 participants

Pilot Evaluation of AboutFace: Novel Peer Education Resource for Veterans

VA Office of Research and Development

NCT02486692

COMPLETED NA 60 participants

Intensive Care Unit (ICU) Diary Project

Tulane University School of Medicine

NCT04305353

COMPLETED NA 59 participants

Peer-led Trauma Therapy for Re-entry

University of Wisconsin, Madison

NCT06019767

COMPLETED 57 participants

Post-Traumatic Stress Disorder (PTSD) Symptom Study

VA Office of Research and Development

NCT00018798

COMPLETED NA 57 participants

The Treatment of Depression With Yoga and Walking

Boston University

NCT02907476

COMPLETED NA 56 participants

Evaluating Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD)

VA Office of Research and Development

NCT05536908

COMPLETED NA 54 participants

Improving Implementation of Evidence Based PTSD Psychotherapy for Veterans in the Community

Veterans Medical Research Foundation

NCT02499432

COMPLETED Phase 2 47 participants

Substance P Antagonist in the Treatment of Posttraumatic Stress Disorder

Baylor College of Medicine

NCT00383786

COMPLETED Phase 2 44 participants

Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence

Medical University of South Carolina

NCT01055171

COMPLETED NA 43 participants

Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment

Massachusetts General Hospital

NCT02447744

COMPLETED Phase 2 41 participants

Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)

Dennis Charney

NCT00749203

COMPLETED Phase 4 40 participants

Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD)

Tuscaloosa Research & Education Advancement Corporation

NCT00203463

COMPLETED NA 40 participants

Care Outcomes for Chiropractic Outpatient Veterans

Palmer College of Chiropractic

NCT03254719

COMPLETED 40 participants

PTSD and Risk Behavior in HIV Positive Female Adolescents

University of North Carolina, Chapel Hill

NCT00271882

COMPLETED Phase 2 38 participants

Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD

Lykos Therapeutics

NCT03282123

COMPLETED NA 36 participants

Pilot Trial of Mobile Mantram Delivery

VA Office of Research and Development

NCT05998967

COMPLETED NA 35 participants

Implementing PTSD Treatment in FQHCs for Michigan Medicaid Enrollees

University of Michigan

NCT03711266

COMPLETED NA 35 participants

Exercise and Therapeutic Learning Among Women With PTSD

University of Wisconsin, Madison

NCT04113798

COMPLETED NA 34 participants

Evaluation of Effectiveness of a Group Yoga Intervention as Trauma Therapy for Adolescent Girls

Hamilton Health Sciences Corporation

NCT02373358

COMPLETED Early Phase 1 33 participants

Supported Education Pilot

US Department of Veterans Affairs

NCT01073657

COMPLETED Phase 1 30 participants

Doxazosin FOR Ptsd

Baylor College of Medicine

NCT02308202

COMPLETED NA 30 participants

RRT for PTSD Symptoms in Survivors of Sexual Violence

University of Colorado, Denver

NCT04073004

COMPLETED 29 participants

Reflective Function as a Mediator of Interpersonal Psychotherapy (IPT)

New York State Psychiatric Institute

NCT02645929

COMPLETED Phase 4 26 participants

Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder

VA Nebraska Western Iowa Health Care System

NCT01271244

COMPLETED 26 participants

Novel EEG Coherence Biomarkers for PTSD Assessment

VA Office of Research and Development

NCT04209387

COMPLETED Phase 4 25 participants

Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence

Medical University of South Carolina

NCT00330239

COMPLETED NA 23 participants

Synchronized Transcranial Magnetic Stimulation for PTSD

Providence VA Medical Center

NCT02981381

COMPLETED NA 21 participants

Efficacy of a Brief Nightmare Treatment for Veterans

University of Tul

NCT01220401

COMPLETED Phase 1 20 participants

Methylphenidate for Ptsd and Stroke Veterans

VA Office of Research and Development

NCT04885257

COMPLETED NA 20 participants

Clinician-Supported PTSD Coach vs. Self-Managed PTSD Coach

Syracuse VA Medical Center

NCT02400710

COMPLETED Phase 2 16 participants

Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD

Icahn School of Medicine at Mount Sinai

NCT04889664

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 22
Phase 3 5
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the PTSD Trial Landscape

155 indexed PTSD studies · 77 recruiting (50%).

Phase mix: 10 late (III/IV) vs 29 early (I/II).

Top sponsor: VA Office of Research and Development (28 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for PTSD?

PlainTrial tracks 155 US clinical trials for PTSD, of which 77 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for PTSD?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.