Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
PTSD: early-phase trial registry
77 of 155 indexed PTSD trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #72 of 28,707 conditions by registered trial count.
155 US clinical trials · 77 currently recruiting · #72 of 28,707 conditions by registered trial count
PTSD: 155 US clinical trials tracked, 77 recruiting.
PTSD is the subject of 155 registered US clinical trials on ClinicalTrials.gov, 77 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 29 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 28 of these trials.
Enrollment posture brief
Registry condition ptsd
OPEN 77 | RECR 50% | LATE 10 | EARLY 29 | RANK #72 | SPON 28
Volume-matched condition peers
Nearest open-share peer: Alzheimer Disease (50% recruiting · 312 trials)
PTSD lists 77 open slots (50% of 155 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for PTSD on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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PTSD is recruiting above its size-band peers.
77 of 155 indexed trials (49.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates PTSD research.
VA Office of Research and Development accounts for 28 of 155 trials (18.1%). 88 distinct sponsors appear on at least one study for this condition label.
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Typical PTSD enrolment sits around 75 participants.
Median target enrolment is 75 among the 155 trials that report a genuine target (sentinel values excluded). 89 of those (57.4%) plan for fewer than 100 participants.
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PTSD research is mostly interventional.
143 interventional and 12 observational studies make up this index (92.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
155 total, page 3 of 4
Web and Shared Decision Making for Reserve/National Guard Women's PTSD Care
VA Office of Research and Development
NCT01710306
Key Dimensions of PTSD and ED
University of California, Los Angeles
NCT03778307
Integrated Alcohol Disorder and PTSD Treatment
VA Office of Research and Development
NCT01601067
Open Label Extension Safety and Efficacy Study of TNX-102 SL Tablets in Military Related PTSD and Related Conditions
Tonix Pharmaceuticals
NCT02421679
Improving Treatment Outcomes for Suicidal Veterans With PTSD
Ohio State University
NCT04690582
Effectiveness of Trauma Management Therapy and Prolonged Exposure Therapy
University of Central Florida
NCT04549493
Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
VA Office of Research and Development
NCT01357577
Implementation of Prolonged Exposure in the Military
University of Pennsylvania
NCT02982538
The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk
Duke University
NCT02736929
Women Overcoming and Managing Adversity Now (WOMAN) Study
UConn Health
NCT01324765
Divalproex Sodium in the Treatment of PTSD (Post-Traumatic Stress Disorder)
VA Office of Research and Development
NCT00108576
Study of PTSD in Military Veterans Who Have Suffered Traumatic Brain Injuries
Carrick Institute for Graduate Studies
NCT02003352
A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD
Tonix Pharmaceuticals
NCT03508700
A Non-Pharmacological Method for Enhancing Sleep in PTSD
University of Arizona
NCT02370173
Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians
University of New Mexi
NCT02124694
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
VA Office of Research and Development
NCT02641496
PTSD Treatment for Incarcerated Men and Women: NIMH
University of Wisconsin, Madison
NCT05168267
Individual PE vs Couples' CBT for Combat-Related Posttraumatic Stress Disorder
Toronto Metropolitan University
NCT02336971
Effect of tDCS Timing on Safety Memory in PTSD
Butler Hospital
NCT04152772
Pilot Evaluation of AboutFace: Novel Peer Education Resource for Veterans
VA Office of Research and Development
NCT02486692
Intensive Care Unit (ICU) Diary Project
Tulane University School of Medicine
NCT04305353
Peer-led Trauma Therapy for Re-entry
University of Wisconsin, Madison
NCT06019767
Post-Traumatic Stress Disorder (PTSD) Symptom Study
VA Office of Research and Development
NCT00018798
The Treatment of Depression With Yoga and Walking
Boston University
NCT02907476
Evaluating Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD)
VA Office of Research and Development
NCT05536908
Improving Implementation of Evidence Based PTSD Psychotherapy for Veterans in the Community
Veterans Medical Research Foundation
NCT02499432
Substance P Antagonist in the Treatment of Posttraumatic Stress Disorder
Baylor College of Medicine
NCT00383786
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
Medical University of South Carolina
NCT01055171
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Massachusetts General Hospital
NCT02447744
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Dennis Charney
NCT00749203
Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD)
Tuscaloosa Research & Education Advancement Corporation
NCT00203463
Care Outcomes for Chiropractic Outpatient Veterans
Palmer College of Chiropractic
NCT03254719
PTSD and Risk Behavior in HIV Positive Female Adolescents
University of North Carolina, Chapel Hill
NCT00271882
Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD
Lykos Therapeutics
NCT03282123
Pilot Trial of Mobile Mantram Delivery
VA Office of Research and Development
NCT05998967
Implementing PTSD Treatment in FQHCs for Michigan Medicaid Enrollees
University of Michigan
NCT03711266
Exercise and Therapeutic Learning Among Women With PTSD
University of Wisconsin, Madison
NCT04113798
Evaluation of Effectiveness of a Group Yoga Intervention as Trauma Therapy for Adolescent Girls
Hamilton Health Sciences Corporation
NCT02373358
Supported Education Pilot
US Department of Veterans Affairs
NCT01073657
Doxazosin FOR Ptsd
Baylor College of Medicine
NCT02308202
RRT for PTSD Symptoms in Survivors of Sexual Violence
University of Colorado, Denver
NCT04073004
Reflective Function as a Mediator of Interpersonal Psychotherapy (IPT)
New York State Psychiatric Institute
NCT02645929
Effects of Escitalopram on Autonomic Reactivity in Post Traumatic Stress Disorder
VA Nebraska Western Iowa Health Care System
NCT01271244
Novel EEG Coherence Biomarkers for PTSD Assessment
VA Office of Research and Development
NCT04209387
Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence
Medical University of South Carolina
NCT00330239
Synchronized Transcranial Magnetic Stimulation for PTSD
Providence VA Medical Center
NCT02981381
Efficacy of a Brief Nightmare Treatment for Veterans
University of Tul
NCT01220401
Methylphenidate for Ptsd and Stroke Veterans
VA Office of Research and Development
NCT04885257
Clinician-Supported PTSD Coach vs. Self-Managed PTSD Coach
Syracuse VA Medical Center
NCT02400710
Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD
Icahn School of Medicine at Mount Sinai
NCT04889664
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 22 |
| Phase 3 | 5 |
| Phase 4 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on PTSD records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on PTSD trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this PTSD page
155 registered trials, 77 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 77 PTSD trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most PTSD trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This PTSD condition card totals 155 registered trials; most-linked intervention Cognitive Processing Therapy; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.