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ClinicalTrials.gov 11 recruiting now official registry

Posttraumatic Stress Disorder (PTSD) clinical trials

11 of 18 indexed Posttraumatic Stress Disorder (PTSD) trials are currently recruiting.

18 US clinical trials · 11 currently recruiting

Posttraumatic Stress Disorder (PTSD) is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 3 of these trials.

The research picture

Posttraumatic Stress Disorder (PTSD) has 18 registered US clinical trials, 11 of them open to new participants right now, about 61% of the total.

11
recruiting participants now
61%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: VA Office of Research and Development
Phase 12Phase 22Phase 41

Active & Recent Trials

18 total, page 1 of 1

RECRUITING Phase 1 288 participants

Inflammatory Challenge and Fear

University of California, San Francisco

NCT06630884

RECRUITING NA 202 participants

Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women

University of California, Los Angeles

NCT06646692

RECRUITING NA 190 participants

Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD

Ohio State University

NCT07238192

RECRUITING NA 168 participants

Project COMET: Massed Prolonged Exposure for PTSD and SUD

Rutgers, The State University of New Jersey

NCT06968832

RECRUITING NA 160 participants

Treatment for PTSD and Tinnitus

The University of Texas Health Science Center at San Antonio

NCT07106593

RECRUITING NA 160 participants

A Neurosensory Account of Anxiety and Stress (Study 2)

The University of Texas Health Science Center, Houston

NCT07079839

RECRUITING NA 160 participants

A Neurosensory Account of Anxiety and Stress (Study 1)

The University of Texas Health Science Center, Houston

NCT05895006

RECRUITING NA 76 participants

Integrated Treatment for Opioid Use Disorder and PTSD

Medical University of South Carolina

NCT06641115

RECRUITING Phase 4 70 participants

Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints

VA Office of Research and Development

NCT05776056

RECRUITING NA 60 participants

Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

University of Texas at Austin

NCT07060144

RECRUITING NA 15 participants

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

The City College of New York

NCT06872164

COMPLETED NA 100 participants

The Impact of Vocational Rehabilitation on Mentally III Veterans

VA Office of Research and Development

NCT00333801

COMPLETED NA 95 participants

fMRI Predictors of Treatment Response in Posttraumatic Stress Disorder (PTSD)

Research Foundation for Mental Hygiene

NCT01576510

COMPLETED NA 94 participants

Brain Imaging of Psychotherapy for Posttraumatic Stress Disorder (PTSD)

Stanford University

NCT01507948

COMPLETED Phase 1 55 participants

Acupuncture for the Treatment of Posttraumatic Stress Among Military Personnel

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT00320138

COMPLETED Phase 2 31 participants

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

Seattle Institute for Biomedical and Clinical Research

NCT02322047

COMPLETED NA 23 participants

Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD

VA Office of Research and Development

NCT03283163

COMPLETED Phase 2 11 participants

Oxytocin and Affect Processing in Posttraumatic Stress Disorder

Yale University

NCT02546570

Reading the Posttraumatic Stress Disorder (PTSD) Trial Landscape

18 indexed Posttraumatic Stress Disorder (PTSD) studies · 11 recruiting (61%).

Phase mix: 1 late (III/IV) vs 4 early (I/II).

Top sponsor: VA Office of Research and Development (3 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Posttraumatic Stress Disorder (PTSD)?

PlainTrial tracks 18 US clinical trials for Posttraumatic Stress Disorder (PTSD), of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Posttraumatic Stress Disorder (PTSD)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.