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NCT06630884 · ClinicalTrials.gov registry record · Phase 1
Inflammatory Challenge and Fear
A Phase 1 study of Posttraumatic Stress Disorder (PTSD), sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 288
- Enrollment target
- 1
- Study location
NCT06630884: Recruiting Phase 1 study of Posttraumatic Stress Disorder (PTSD), sponsored by University of California, San Francisco.
NCT06630884 is a Phase 1 study of Posttraumatic Stress Disorder (PTSD) that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 288 participants, above the 102-participant average among 31 other Posttraumatic Stress Disorder (PTSD) trials with a reported enrollment target (182% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06630884, a Phase 1 study of Posttraumatic Stress Disorder (PTSD), is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 288 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.
Primary Outcome
Skin conductance level (SCL)will be sampled at 1000 Hz beginning 2 s prior to the conditioned stimulus (CS) onset and continuing until 6 s following CS offset. The skin conductance response (SCR) score for each CS interval will be obtained by subtracting the mean SCL for the 2 s preceding CS onset from the peak during the 8 s CS interval.
Conditions Studied
Interventions
- BIOLOGICAL Typhoid VI Polysaccharide Vaccine Injectable Solution
- OTHER Saline Placebo (0.5mL injection)
Study Locations (1)
California
- San Francisco VA Health Care System - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 288 participants |
| Start Date | 2025-03-28 |
| Est. Completion | 2028-11 |
| Phase | Phase 1 |
What NCT06630884 shows while recruiting
NCT06630884 is an interventional study that assigns participants to a tested intervention. The registered 288 participants enrollment target is mid-sized for trials with a published cap, above the 102-participant average among 31 other Posttraumatic Stress Disorder (PTSD) trials with a reported enrollment target (182% higher).
The record links to 1 condition, with Posttraumatic Stress Disorder (PTSD) appearing as the primary indexed condition, and to 2 interventions - of which Typhoid VI Polysaccharide Vaccine Injectable Solution is the first listed.
NCT06630884 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06630884 about?
NCT06630884 is a clinical study titled "Inflammatory Challenge and Fear". The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who rece...
What is the current status of trial NCT06630884?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 288 participants. The study started on 2025-03-28. Estimated completion is 2028-11.
What conditions does trial NCT06630884 study?
This clinical trial studies the following conditions: Posttraumatic Stress Disorder (PTSD).
What interventions are being tested in trial NCT06630884?
The interventions under investigation include: Typhoid VI Polysaccharide Vaccine Injectable Solution (BIOLOGICAL), Saline Placebo (0.5mL injection) (OTHER).
Who is sponsoring clinical trial NCT06630884?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06630884 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Posttraumatic Stress Disorder (PTSD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06630884's enrollment target sits among peer trials
288 2nd of 31 the highest of 31 other Posttraumatic Stress Disorder (PTSD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Posttraumatic Stress Disorder (PTSD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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