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NCT06646692 · ClinicalTrials.gov registry record · NA
Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women
A NA study of Anxiety and Depression - Major Depressive Disorder, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- NA
- Development phase
- 202
- Enrollment target
- 1
- Study location
NCT06646692 is a NA study of Anxiety and Depression - Major Depressive Disorder that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 202 participants, below the 439-participant average among 364 other Anxiety trials with a reported enrollment target (54% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06646692, a NA study of Anxiety and Depression - Major Depressive Disorder, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- NA
- Development phase
- 202 participants
- Enrollment target
- 1
- Study location
Study Summary
Trauma exposure, posttraumatic stress disorder (PTSD), and substance use disorder (SUD) present major threats to public health. PTSD and SUD are major correlates of disability, often resulting in severe social and occupational impairment. Comorbidity between PTSD and SUD (PTSD/SUD) is common and frequently co-occurs with other mental health ailments including depression, anxiety, and suicidality. Comorbidity may be amplified in groups vulnerable to high trauma exposure, such as women with low socioeconomic status including women experiencing homelessness (WEH). Moreover, the reciprocal nature of PTSD/SUD (substances are used to cope with PTSD symptoms; substance use can create high-risk situations for new traumas to occur), can create a cycle of trauma and symptomatology leading to a critical health disparity. PTSD/SUD can be costly and difficult to treat, with treatment completion often low and relapse rates often high. Low-cost, complementary interventions, such as self-compassion (SC) interventions, which target key mechanisms that maintain PTSD/SUD, could improve treatment outcomes. SC interventions include practices that build skills to improve emotional responses, cognitive understanding, and mindfulness. Recent research supports the benefit of SC interventions for reducing PTSD, SUD, and related comorbidities, potentially with large effects. However, sample sizes have generally been small and randomized designs infrequently used. Moreover, while SC interventions may act to improve key mechanisms of treatment response and/or symptom maintenance (e.g., emotion regulation/dysregulation, trauma-related guilt, trauma-related shame, moral injury, and craving), such mediating factors have been underexplored. To address these limitations, the present proposal will implement community-based research principles and use a two phase, mixed-method design to adapt and test a widely used SC intervention (Mindful Self Compassion; MSC) for use with a sample of WEH with PTSD/
Conditions Studied
Interventions
- BEHAVIORAL Treatment as Usual (TAU)
- BEHAVIORAL Mindful Self Compassion
Study Locations (1)
California
- Prototypes - Pomona
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 202 participants |
| Start Date | 2024-05-05 |
| Est. Completion | 2026-01-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06646692
The ClinicalTrials.gov registry entry for NCT06646692 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 202 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 439-participant average among 364 other Anxiety trials with a reported enrollment target (54% lower). The listed sponsor is University of California, Los Angeles, which has 897 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Anxiety appearing as the primary indexed condition, and to 2 interventions - of which Treatment as Usual (TAU) is the first listed.
NCT06646692 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06646692 about?
NCT06646692 is a clinical study titled "Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women". Trauma exposure, posttraumatic stress disorder (PTSD), and substance use disorder (SUD) present major threats to public health. PTSD and SUD are major correlates of disability, often resulting in severe social and occupational impairment. Comorbidity between PTSD and SUD (PTSD/SUD) is common and fre...
What is the current status of trial NCT06646692?
This trial is currently recruiting. It is a NA study. The enrollment target is 202 participants. The study started on 2024-05-05. Estimated completion is 2026-01-31.
What conditions does trial NCT06646692 study?
This clinical trial studies the following conditions: Anxiety, Depression - Major Depressive Disorder, Posttraumatic Stress Disorder (PTSD).
What interventions are being tested in trial NCT06646692?
The interventions under investigation include: Treatment as Usual (TAU) (BEHAVIORAL), Mindful Self Compassion (BEHAVIORAL).
Who is sponsoring clinical trial NCT06646692?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06646692 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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