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RECRUITING Phase 1

First in Human Phase1/2a Clinical Trial of Anti-PAUF Monoclonal Antibody PBP1510 in Patients With Pancreatic Cancer

NCT05141149 · View on ClinicalTrials.gov ↗

Study Summary

The first in human clinical study is planned as an open-label, dose-escalation, and dose-expansion, multicentre, two-part, Phase 1/2a study of PBP1510 administered to patients with advanced/metastatic pancreatic cancer. The study will be conducted in two parts, Part 1 as a PBP1510 single agent dose-escalation, and PBP1510 dose-escalation in combination with gemcitabine, and Part 2 as PBP1510 dose-expansion at the RP2D in combination with gemcitabine.

Conditions Studied

Interventions

  • DRUG PBP1510 (400mg/16mL)
  • DRUG Gemcitabine (1000 mg/m^2)

Study Locations (4)

Other

  • Monash Health — Melbourne
  • National Cancer Centre Singapore — Singapore

New York

  • Northwell Health / R.J. Zuckerberg Cancer Center — New Hyde Park

Madrid

  • Hospital Universitario La Paz — Madrid

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2023-06-05
Est. Completion 2026-12
Phase Phase 1

Sponsor

Prestige Biopharma Limited

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05141149

The ClinicalTrials.gov registry entry for NCT05141149 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Prestige Biopharma Limited, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Pancreatic Cancer appearing as the primary indexed condition, and to 2 interventions — of which PBP1510 (400mg/16mL) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05141149 reports 4 study locations spanning 3 distinct geographic areas — top geographies include Other, New York, Madrid. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05141149 about?

NCT05141149 is a clinical study titled "First in Human Phase1/2a Clinical Trial of Anti-PAUF Monoclonal Antibody PBP1510 in Patients With Pancreatic Cancer". The first in human clinical study is planned as an open-label, dose-escalation, and dose-expansion, multicentre, two-part, Phase 1/2a study of PBP1510 administered to patients with advanced/metastatic pancreatic cancer. The study will be conducted in two parts, Part 1 as a PBP1510 single agent dose-...

What is the current status of trial NCT05141149?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2023-06-05. Estimated completion is 2026-12.

What conditions does trial NCT05141149 study?

This clinical trial studies the following conditions: Pancreatic Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05141149?

The interventions under investigation include: PBP1510 (400mg/16mL) (DRUG), Gemcitabine (1000 mg/m^2) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05141149?

This trial is sponsored by Prestige Biopharma Limited, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05141149 being conducted?

This trial has 4 study locations across New York, Madrid. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial