Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 6 of 8
Pain and Anxiety Management With Oral Narcotic for Pediatric Suture Repair
Baylor College of Medicine
NCT01053637
The cryoICE™ CryoAnalgesia Study For Pain Management in Post thoRacic Procedures Via intercOSTal Cryoanalgesia (FROST)
AtriCure
NCT02922153
Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery
Duke University
NCT02829944
Subcutaneous Botulinum Toxin for Cutaneous Allodynia
Stanford University
NCT00725322
Buzzy Versus Vapocoolant Spray: Pediatric Needle Pain Relief
Georgia State University
NCT00919100
Lavender Aromatherapy for Anxiety During Urodynamics
University of Southern California
NCT02344745
A Single-dose Study of Intranasal Ketorolac in the Treatment of Pain Secondary to Dental Impaction Surgery
Egalet
NCT01356225
A Study of Sternal Closure After Open Heart Surgery: Rigid Versus Wire Closure
Thomas Jefferson University
NCT01317095
Outcomes Study of MTM in a Medicare ACO
HealthEast Care System
NCT02875925
Low Dose Ketamine for Management of Acute Severe Pain in the Emergency Department
Rhode Island Hospital
NCT01740492
Visual Stimulation for Pain Relief
Dandelion Science
NCT06276881
LIA in Hip Arthroscopy Patients
University of Utah
NCT03070054
Virtual Empowered Relief for Chronic Pain
Stanford University
NCT05057988
Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation
Baylor College of Medicine
NCT04269239
Cannabinoids for Pain Control During Medical Abortion
Oregon Health and Science University
NCT03604341
The Effect of Intraoperative Esmolol to Improve Postoperative Quality of Recovery and Pain After Ambulatory Surgery
Northwestern University
NCT01782898
Nicotine Patch as an Analgesic Adjuvant After Surgery
Columbia University
NCT00440830
A Study to Evaluate the Safety and Pharmacokinetics of CNTX-6016 in Healthy Subjects
Centrexion Therapeutics
NCT04154501
An Implantable Spinal Cord Stimulation Pain Management System
Boston Scientific Corporation
NCT00205855
A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain
Antonios Likourezos
NCT04860804
Magnesium vs Placebo for Tonsillectomy
Ann & Robert H Lurie Children's Hospital of Chicago
NCT02218424
Attenuation of Pain in Men and Women
University of Wisconsin, Madison
NCT01220414
Pharmacokinetics, Safety, and Efficacy of SPRIX in 12 to 17 Year Old Patients vs. Adult Patients Undergoing Open Surgical Procedures
American Regent
NCT01819610
The Learning and Memory of the Experience of Pain
Massachusetts General Hospital
NCT01731314
A Comparison of INSORB Staples With Metal Staples in Total Hip Replacement
Orthopaedic Research Foundation
NCT00940446
5-minute Mindful Pain Management Strategy
Florida State University
NCT06394765
The Role of Opioidergic Systems in Breathing Based Analgesia
University of California, San Diego
NCT03419858
Omega-3 Fatty Acid in Treating Pain in Patients With Breast or Ovarian Cancer Receiving Paclitaxel
New Mexico Cancer Research Alliance
NCT01821833
Combined Spinal-Epidural Temperature and Duration of Action
Wake Forest University Health Sciences
NCT02020304
Medrol Dose Packs for Post-Operative Pain Control
University of Utah
NCT06453083
Safety/Efficacy of Nepafenac Punctal Plug Delivery System Compared to Placebo to Control Ocular Pain/Inflammation After Cataract
Mati Therapeutics
NCT03496467
Efficacy of Probiotic Bacteria in Subjects With IBS or Functional Diarrhea/ Bloating
University of North Carolina, Chapel Hill
NCT00618904
H2O VR for Burns 2015
National Institute of General Medical Sciences (NIGMS)
NCT02729259
Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement
Trinity Health Of New England
NCT01805661
Dilution of Verapamil During Intraarterial Administration
University of Illinois at Chicago
NCT05625503
Intrathecal Hydromorphone for Cesarean Section
Thomas Jefferson University
NCT02067520
A Bioequivalence Study of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) Versus Advil Dual Action Caplets (125 mg/250 mg) and Bioavailability Assessment of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) and Advil Liqui-Gels (200 mg) in Healthy Adult Subjects
HALEON
NCT06802185
Cutaneous Effects of Cryogen Spray Cooling
University of California, Irvine
NCT00581568
Intravitreal Injection Site and Perceived Pain
The University of Texas Medical Branch, Galveston
NCT05640895
Ibuprofen 5% Topical Gel CIPT
Pfizer
NCT01771822
The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients
Northwestern University
NCT01433081
Rheumatoid Arthritis Coping Enhancement
Duke University
NCT04246827
S1008: Exercise, Diet, & Counseling in Improving Weight Loss in Overweight Female Breast or Colorectal Cancer Survivors
SWOG Cancer Research Network
NCT01453452
Pain Evaluation and Treatment
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00362167
Pilot Study to Evaluate the Effect of Aromatase Inhibitor Therapy on Pain Threshold in Breast Cancer Patients
University of Michigan Rogel Cancer Center
NCT01814397
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)
University of Utah
NCT04772222
A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adults
Sparian Biosciences
NCT05721287
Ketamine: Comparison of IV Push vs. IV Drip
Antonios Likourezos
NCT02363270
Study of Pain Processing in Experienced Yoga Practitioners
National Center for Complementary and Integrative Health (NCCIH)
NCT02055235
The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENT
University of Florida
NCT02729350
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.