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NCT01782898 · ClinicalTrials.gov registry record · NA
The Effect of Intraoperative Esmolol to Improve Postoperative Quality of Recovery and Pain After Ambulatory Surgery
A NA study of Pain, sponsored by Northwestern University.
- Completed
- Registry status
- NA
- Development phase
- 70
- Enrollment target
- 1
- Study location
NCT01782898 is a NA study of Pain that has completed, run by Northwestern University. The registered enrollment target is 70 participants, below the 304-participant average among 374 other Pain trials with a reported enrollment target (77% lower). The trial reports 1 study location across 1 state.
The verdict
NCT01782898, a NA study of Pain, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 70 participants
- Enrollment target
- 1
- Study location
Study Summary
Seventy percent of surgeries performed in the United States are done in an outpatient setting.Pain Control after ambulatory surgery is very challenging because patients do not have access to fast and potent intravenous medications Pain after ambulatory surgery is poorly controlled in the United States with up to seventy five percent of patients having moderate to severe pain after ambulatory procedures. Postoperative pain have been associated with serious morbidity, including myocardial infarction and pulmonary embolism. The use of intraoperative opioids can result in an exaggerated response to pain (hyperalgesia) and contribute to an exacerbation of pain after surgical procedures.Opioids are commonly given intraoperative, not in response to pain, but in response to hyperdynamic cardiovascular states. Esmolol is a short acting beta 1 antagonist that can be used to treat/prevent hyperdynamic states during surgery. More importantly, esmolol has been shown to have central antihyperalgesic effects that might contribute to a reduction in postoperative pain. It is therefore conceivable that the use of intraoperative esmolol instead of opioids to avoid hyperdynamic states during surgery can result in lower postoperative pain. Since postoperative pain can substantially affect postoperative quality of recovery, it is also conceivable that the use of intraoperative esmolol might result in an improved postoperative quality of recovery to surgical patients. The main objective of the current study is to examine the effect of intraoperative esmolol on postoperative quality of recovery. A secondary objective is to examine the effect of esmolol on postoperative pain. Significance: Postoperative pain after ambulatory surgery has been shown to be poorly managed in The United States. The goal of this study is to investigate if a change in the intraoperative pharmacologic management of patients undergoing ambulatory surgery can improve their postoperative quality of recovery and pai
Conditions Studied
Interventions
- DRUG Esmolol administered at a rate of 0.5 mg/kg followed by an infusion of 5-15 mcg/kg/min
- DRUG Placebo Comparator: .9 normal saline
Study Locations (1)
Illinois
- Prentice Womens Hospital - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2013-01 |
| Est. Completion | 2014-12 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01782898
The ClinicalTrials.gov registry entry for NCT01782898 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 304-participant average among 374 other Pain trials with a reported enrollment target (77% lower). The listed sponsor is Northwestern University, which has 1,209 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Pain appearing as the primary indexed condition, and to 2 interventions - of which Esmolol administered at a rate of 0.5 mg/kg followed by an infusion of 5-15 mcg/kg/min is the first listed.
NCT01782898 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.
Frequently Asked Questions
What is clinical trial NCT01782898 about?
NCT01782898 is a clinical study titled "The Effect of Intraoperative Esmolol to Improve Postoperative Quality of Recovery and Pain After Ambulatory Surgery". Seventy percent of surgeries performed in the United States are done in an outpatient setting.Pain Control after ambulatory surgery is very challenging because patients do not have access to fast and potent intravenous medications Pain after ambulatory surgery is poorly controlled in the United Stat...
What is the current status of trial NCT01782898?
This trial is currently completed. It is a NA study. The enrollment target is 70 participants. The study started on 2013-01. Estimated completion is 2014-12.
What conditions does trial NCT01782898 study?
This clinical trial studies the following conditions: Pain.
What interventions are being tested in trial NCT01782898?
The interventions under investigation include: Esmolol administered at a rate of 0.5 mg/kg followed by an infusion of 5-15 mcg/kg/min (DRUG), Placebo Comparator: .9 normal saline (DRUG).
Who is sponsoring clinical trial NCT01782898?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01782898 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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