Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 7 of 8
Lower Extremity Splinting to Manage Pain and Sleep Disturbances Associated With HIV/AIDS Related Peripheral Neuropathy
Texas Woman's University
NCT01419314
Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel
Academic and Community Cancer Research United
NCT01637077
Evaluation of Dexmedetomidine on Post-operative Narcotic Requirements and Pain Scores in Bariatric Patients
West Virginia University
NCT02604940
Initial Assessment of an Internet-based Symptom Management Intervention in Early Stage Breast Cancer
University of Michigan
NCT02495155
Bridge Device for Surgical Pain for Rotator Cuff Surgery
Steven Orebaugh
NCT06071884
D-cycloserine in the Management of Chronic Low Back Pain
Thomas J. Schnitzer
NCT00125528
Exercise Dosing for Pain in Healthy Participants
Duquesne University
NCT03642938
Topical Lidocaine for Pain Control With Intrauterine Device (IUD) Insertion
University of Wisconsin, Madison
NCT01445756
Brain Mechanisms Supporting Meditation-based Analgesia
University of California, San Diego
NCT03414138
Duration of Skin Numbing Effect Created by the S-Caine™ Peel
ZARS Pharma
NCT00110253
Virtual Reality in Plastic Surgery: Pain Control and Augmented Satisfaction
The Guthrie Clinic
NCT03914937
Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer
Virginia Commonwealth University
NCT01196442
Pilot Functional Imaging Study to Evaluate Mechanisms Underlying Chronic Pain in Breast Cancer Patients
Lynn Henry
NCT01639417
Flow-Restorative Yoga to Decrease Pain and Inflammation
Cornell University
NCT03790098
Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media
Arbor Pharmaceuticals
NCT01588535
Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion
University of Wisconsin, Madison
NCT00205101
Acupuncture for the Treatment of Vulvodynia
Schlaeger, Judith M., CNM, LAc, PhD
NCT02197429
Pain Sensitivity During Puberty
Washington University School of Medicine
NCT05145595
Ultravision Visual Clearing System in Laparoscopic Hysterectomy and Myomectomy
Mercy Research
NCT03634306
Stereotactic Body Radiation Therapy and Vertebroplasty in Treating Patients With Localized Spinal Metastasis
University of Texas Southwestern Medical Center
NCT00855803
Port Size and Post-Operative Pain Perception by Patients
Loyola University
NCT02521987
Exercise-induced Hypoalgesia After Comparative Forms of Exercise
University of Wisconsin, Madison
NCT01883895
Negating Opioid and Pain Actively Through Intervention
Loma Linda University
NCT03306147
Modifying Exercise for the COPD Patient
Angela N Fellner PhD CCRP
NCT02143206
Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors
Ohio State University Comprehensive Cancer Center
NCT01929720
Intravenous Lidocaine Versus Morphine for Severe Pain in the ED
Alameda Health System
NCT02912195
Improving Care of Patients With Heart Failure
University of California, San Francisco
NCT01461681
Perioperative Inflammation and Cyclooxygenase 2 (COX-2)
University of Washington
NCT00122096
Auranofin in Decreasing Pain in Patients With Paclitaxel-Induced Pain Syndrome
Mayo Clinic
NCT02063698
Effect of Samarium on the Relief of Pain Due to Vertebral Metastases
New York Presbyterian Brooklyn Methodist Hospital
NCT00374751
Non-Randomized Trial Assessing Pain Efficacy With Radium-223 in Symptomatic Metastatic Castration-Resistant Prostate Cancer
Memorial Sloan Kettering Cancer Center
NCT02278055
Virtual Reality in Burn Pain Management
United States Army Institute of Surgical Research
NCT00593086
Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
University of North Carolina, Chapel Hill
NCT03562481
Safety and Efficacy of a Low Dose Naloxone Infusion in NICU Patients
Children's Mercy Hospital Kansas City
NCT00669175
A Randomized Study Investigating Oral Desmetramadol Dose Proportionality and Food Effect In Normal Human Subjects
Syntrix Biosystems
NCT04683926
Clonidine Versus Adenosine to Treat Neuropathic Pain
Wake Forest University Health Sciences
NCT00349921
Efficacy of Steroid Supplementation After TMJ Rinsing for Pain Management
University of Florida
NCT01770912
An Investigator Initiated, Within-Subject, Proof of Concept Study to Assess the Efficacy and Safety of Voltaren Gel in Subjects With DOMS
Lotus Clinical Research
NCT02087748
Effect of Temperature on Pain and Brown Adipose Activity in Fibromyalgia
University of Minnesota
NCT01322425
Pain Management Smartphone Application for Patients With Stage III-IV Head and Neck Cancer Undergoing Radiation Therapy
Vanderbilt-Ingram Cancer Center
NCT02324881
Comparing Mirror Therapy Rehabilitation Device to Conventional Mirror Therapy
Yale University
NCT06842888
A Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-993
Vertex Pharmaceuticals Incorporated
NCT06508762
Effect of the DentalVibe Injection System on Pain During Local Anesthesia Injections in Children
University of Nebraska
NCT03374982
Pain Control in Hospice Patients With Cancer-Related Pain
Vanderbilt-Ingram Cancer Center
NCT00609297
Management of Pain in Persons With Multiple Sclerosis
University of Washington
NCT00621374
Novel Technique for Botulinum Toxin Injection to Minimize Patient Discomfort
Henry Ford Health System
NCT00628472
Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children
Columbia University
NCT01549002
Reducing Brief Thermal and Electrical Pain (Four Study Days)
University of Washington
NCT00682682
Ropivacaine Pharmacokinetics in ESP Blocks
Thomas Jefferson University
NCT04807504
Testing the Effects of an Algorithm for Neuropathic Pain on Patient and System Outcomes
Dartmouth-Hitchcock Medical Center
NCT00130130
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.