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Pain: full-pipeline trial registry
106 of 377 indexed Pain trials are currently recruiting.
Corpus placement: #16 of 28,707 conditions by registered trial count.
377 US clinical trials · 106 currently recruiting · #16 of 28,707 conditions by registered trial count
Pain: 377 US clinical trials tracked, 106 recruiting.
Pain is the subject of 377 registered US clinical trials on ClinicalTrials.gov, 106 of them currently open to new participants. 73 are in Phase 3-4 (later-stage) and 79 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 9 of these trials.
Enrollment posture brief
Registry condition pain
OPEN 106 | RECR 28% | LATE 73 | EARLY 79 | RANK #16 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Astigmatism (28% recruiting · 32 trials)
Pain lists 106 open slots (28% of 377 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Pain is recruiting below its size-band peers.
106 of 377 indexed trials (28.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Pain trials is spread across many organizations.
University of Florida accounts for 9 of 377 trials (2.4%). 214 distinct sponsors appear on at least one study for this condition label.
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Typical Pain enrolment sits around 84 participants.
Median target enrolment is 84 among the 375 trials that report a genuine target (sentinel values excluded). 201 of those (53.6%) plan for fewer than 100 participants.
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Pain research is mostly interventional.
319 interventional and 58 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
377 total, page 5 of 8
Thermal Analgesia in Newborns
University of Chicago
NCT00740298
Intravenous Tapentadol in Post-Bunionectomy Pain
Grünenthal
NCT01435577
Patient-Empowered Mobile Technology in Hospitalized Patients (TRU-PAIN)
Duke University
NCT02895841
Legacy Intervention Family Enactment (LIFE)
University of Alabama, Tuscaloo
NCT02007564
A Study to Evaluate Safety and Efficacy Following Dosing of Oxycodone/Naltrexone for Treatment of Adults With Pain Following Bunionectomy Surgery
Elite Laboratories
NCT02401750
Preventing Propofol-associated Injection Pain
Benaroya Research Institute
NCT00864682
Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children With Moderate to Severe Malignant and/ or Nonmalignant Pain Requiring Opioids
Purdue Pharma
NCT01192295
Local Anesthetics for Pain Reduction Prior to IV Line Placement
Allina Health System
NCT01759459
Surveillance Trial to Evaluate a Shortened Infusion Time of Intravenous Ibuprofen
Cumberland Pharmaceuticals
NCT01334944
Role of B2 Adrenergic Receptors in Labor Pain
Columbia University
NCT00385294
Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery
Nemours Children's Clinic
NCT03062488
Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children
Lachlan Pharma Holdings
NCT03116737
Double Blinded Randomized Trial Between Lidocaine And Plain Gel For Urethral Straight Catheterization And The Q-Tip Test
Baystate Medical Center
NCT00883103
Validation of the Sickle Cell Disease Pain Burden Interview
Connecticut Children's Medical Center
NCT00804362
Telehealth Outreach for Chronic Back Pain
VA Office of Research and Development
NCT00608530
Nurse-Provided Care or Standard Care in Treating Patients With Pancreatic Cancer
City of Hope Medical Center
NCT00902733
Chronic Pain After Amputation
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00006427
Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis
Montefiore Medical Center
NCT01482091
A Study of Ibuprofen (IBU) 250mg/APAP 500mg In The Treatment Of Post-Surgical Dental Pain
Pfizer
NCT02837952
Enhancing Management of Chronic Pain and Symptoms Among Women Treated for Breast Cancer (Lymph-Flow)
NYU Langone Health
NCT02462226
A Study to Assess the Analgesic Properties of a Sublingual Wafer Formulation of Ketamine Following Third Molar Extraction
Lotus Clinical Research
NCT02199678
Mind Engagement With Music for Nondrug Pain Relief
University of Utah
NCT00103870
Pain Management for Veterans Filing Compensation Claims
Yale University
NCT02049086
Study to Evaluate the OrthoCor Active System for Pain Relief
Caerus Corporation
NCT05244187
Preoperative Psychosocial Support for Postoperative Recovery and Health: Mechanistic Substudy
University of Utah
NCT04520958
Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee
ZARS Pharma
NCT00108810
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
Mylan
NCT04571515
Randomized Control Trial of a Topical Anesthetic to Evaluate Pain and Anxiety During Venipuncture
Jenny Boucher, PharmD
NCT00676364
Assessing the Impact of LIve Music in the Intensive Care Unit (ICU) to Improve Care for Critically Ill Patients
Vanderbilt University Medical Center
NCT03948984
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
Mylan Specialty
NCT05317312
Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department
Hennepin Healthcare Research Institute
NCT02404610
Multiple Dose Dental Pain Study Of Ibuprofen Extended Release
Pfizer
NCT01266161
Palliative Radiation Therapy in Reducing Pain in Patients With Bone Metastasis
Wake Forest University Health Sciences
NCT02699697
Regenerex Tibial Tray Multi-Center Data Collection
Zimmer Biomet
NCT00859963
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Cedars-Sinai Medical Center
NCT03723447
Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00001725
Music and Local Anesthesia During Dermatologic Procedures
Washington University School of Medicine
NCT04317170
Mechanisms of Sleep Disruption Hyperalgesia
Johns Hopkins University
NCT01794689
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Ohio State University
NCT01574807
Additional Positron Emission Tomography (PET) Scan of Brain in Patients Undergoing PET Scan for Diseases Unrelated to Brain
Asokumar Buvanendran
NCT00729092
Video Education Intervention in the Emergency Department
Medical College of Wisconsin
NCT01471769
Brachial Plexus Block in Post-Op Pain Control After Distal Upper Extremity Fracture: A Prospective Randomized Study
NYU Langone Health
NCT01968824
Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain
Vanderbilt-Ingram Cancer Center
NCT00666211
Applying Num Vapocoolant Spray to Cervix Before Paracervical Block to Decrease Pain During Gynecology Procedures
Queen's Medical Center
NCT06227052
Study of a Multimodality Pain Management Protocol on Postoperative Neurosurgical Pain
University of Florida
NCT01693588
Neurofeedback Treatment of Pain in Persons With Spinal Cord Injury (SCI)
University of Washington
NCT00947999
Brain Response to Pain Control in People With Chronic Pain
National Center for Complementary and Integrative Health (NCCIH)
NCT01878019
Evaluation of Pain Measurement Device
Stanford University
NCT02036567
Psychological Treatments for Scleroderma
Johns Hopkins University
NCT00007267
Single Shot vs Continuous Interscalene Block for Rotator Cuff Repair
University of Chicago
NCT01122745
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 40 |
| Phase 2 | 39 |
| Phase 3 | 36 |
| Phase 4 | 37 |
Top Sponsors
Named interventions
Most-linked intervention names on Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Pain page
377 registered trials, 106 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 106 Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Florida sponsors the most Pain trials on record, review their full trial history before evaluating a specific study. See University of Florida's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Pain condition card totals 377 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.