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NCT06043440 · ClinicalTrials.gov registry record · Phase 2
Down Syndrome Obstructive Sleep Apnea
A Phase 2 study of Obstructive Sleep Apnea and Down Syndrome, sponsored by Brigham and Women's Hospital.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 230
- Enrollment target
- 7
- Study locations
NCT06043440: Recruiting Phase 2 study of Obstructive Sleep Apnea and Down Syndrome, sponsored by Brigham and Women's Hospital.
NCT06043440 is a Phase 2 study of Obstructive Sleep Apnea and Down Syndrome that is actively recruiting participants, run by Brigham and Women's Hospital. The registered enrollment target is 230 participants, roughly in line with the 220-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target. The trial reports 7 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06043440, a Phase 2 study of Obstructive Sleep Apnea and Down Syndrome, is actively recruiting participants, sponsored by Brigham and Women's Hospital.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 230 participants
- Enrollment target
- 7
- Study locations
Study Summary
The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).
Primary Outcome
Change from baseline in the Behavior Rating Inventory of Executive Function 2 (BRIEF2) working memory score (BRIEF2wm). The score ranges from 35-90. A higher score is a worse outcome.
Conditions Studied
Interventions
- DRUG Oxygen
Study Locations (7)
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
- Rainbow Babies and Children's Hospital, Case Medical Center - Cleveland
California
- Children's Hospital of Los Angeles - Los Angeles
Michigan
- University of Michigan, Ann Arbor Hospital - Ann Arbor
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Virginia
- East Virginia Medical Center - Norfolk
Washington
- Seattle Children's Hospital - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 230 participants |
| Start Date | 2023-10-24 |
| Est. Completion | 2027-12-30 |
| Phase | Phase 2 |
What NCT06043440 shows while recruiting
NCT06043440 is an interventional study that assigns participants to a tested intervention. The registered 230 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 220-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target.
The record links to 2 conditions, with Obstructive Sleep Apnea appearing as the primary indexed condition, and to 1 intervention - of which Oxygen is the first listed.
NCT06043440 lists 7 locations in 6 states (Ohio, California, Michigan).
Frequently Asked Questions
What is clinical trial NCT06043440 about?
NCT06043440 is a clinical study titled "Down Syndrome Obstructive Sleep Apnea". The purpose of this study is to assess whether oxygen supplementation during sleep improves working memory and other clinical and patient-reported outcomes among children who have Down Syndrome (DS) with moderate to severe Obstructive Sleep Apnea (OSA).
What is the current status of trial NCT06043440?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 230 participants. The study started on 2023-10-24. Estimated completion is 2027-12-30.
What conditions does trial NCT06043440 study?
This clinical trial studies the following conditions: Obstructive Sleep Apnea, Down Syndrome.
What interventions are being tested in trial NCT06043440?
The interventions under investigation include: Oxygen (DRUG).
Who is sponsoring clinical trial NCT06043440?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06043440 being conducted?
This trial has 7 study locations across California, Michigan, Ohio, Pennsylvania, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obstructive Sleep Apnea
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06043440's enrollment target sits among peer trials
230 35th of 155 higher than 121 of 155 other Obstructive Sleep Apnea trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obstructive Sleep Apnea trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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