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NCT05094271 · ClinicalTrials.gov registry record · Phase 1
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
A Phase 1 study of Alzheimer Disease and Obstructive Sleep Apnea, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 260
- Enrollment target
- 1
- Study location
NCT05094271: Recruiting Phase 1 study of Alzheimer Disease and Obstructive Sleep Apnea, sponsored by University of California, San Diego.
NCT05094271 is a Phase 1 study of Alzheimer Disease and Obstructive Sleep Apnea that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 260 participants, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05094271, a Phase 1 study of Alzheimer Disease and Obstructive Sleep Apnea, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 260 participants
- Enrollment target
- 1
- Study location
Study Summary
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.
Primary Outcome
The number of times a person stops breathing and periods of shallow breathing with a marked decrease in blood oxygen concentration every hour on average. A score lower than five indicates normal sleep (no sleep apnea), 5-15 indicates mild sleep apnea, 15-30 indicates moderate sleep apnea, and a score greater than 30 indicates severe sleep apnea. Result specified as change from room air condition to oxygen condition during the crossover trial
Conditions Studied
Interventions
- OTHER Supplemental Oxygen
- DEVICE Continuous Positive Airway Pressure Machine
- OTHER Room Air
Study Locations (1)
California
- UCSD Sleep Research - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 260 participants |
| Start Date | 2021-06-30 |
| Est. Completion | 2025-05-20 |
| Phase | Phase 1 |
What NCT05094271 shows while recruiting
NCT05094271 is an interventional study that assigns participants to a tested intervention. The registered 260 participants enrollment target is mid-sized for trials with a published cap, below the 2,750-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (91% lower).
The record links to 4 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 3 interventions - of which Supplemental Oxygen is the first listed.
NCT05094271 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05094271 about?
NCT05094271 is a clinical study titled "Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?". Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apn...
What is the current status of trial NCT05094271?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 260 participants. The study started on 2021-06-30. Estimated completion is 2025-05-20.
What conditions does trial NCT05094271 study?
This clinical trial studies the following conditions: Alzheimer Disease, Obstructive Sleep Apnea, Sleep Apnea, OSA.
What interventions are being tested in trial NCT05094271?
The interventions under investigation include: Supplemental Oxygen (OTHER), Continuous Positive Airway Pressure Machine (DEVICE), Room Air (OTHER).
Who is sponsoring clinical trial NCT05094271?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05094271 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05094271's enrollment target sits among peer trials
260 88th of 306 higher than 219 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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