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NCT05050383 · ClinicalTrials.gov registry record · NA
DISE: Phenotyping Obstruction Patterns
A NA study of Obstructive Sleep Apnea, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- NA
- Development phase
- 241
- Enrollment target
- 1
- Study location
NCT05050383: Recruiting NA study of Obstructive Sleep Apnea, sponsored by University of Pennsylvania.
NCT05050383 is a NA study of Obstructive Sleep Apnea that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 241 participants, above the 220-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (10% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05050383, a NA study of Obstructive Sleep Apnea, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- NA
- Development phase
- 241 participants
- Enrollment target
- 1
- Study location
Study Summary
Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction. The investigators will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships, deriving functional determinants of upper airway obstruction during sleep. In addition, they will use objective anatomic measurements from computerized tomography (CT) and submental ultrasound. The findings will allow the investigators to streamline the upper airway exam during DISE, and will further the goal of developing personalized solutions that address specific pathogenic mechanisms of pharyngeal collapse and airflow obstruction during sleep. The investigators will use the physiologic and anatomic features derived from DISE and imaging to determine which are predictive of success to standard-of-care surgical interventions (e.g. skeletal, soft tissue, neurostimulation) .
Primary Outcome
Change in pre-operative to post-operative AHI
Conditions Studied
Interventions
- OTHER Pharyngeal Manometry
- OTHER Submental Ultrasound
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 241 participants |
| Start Date | 2021-11-12 |
| Est. Completion | 2027-09 |
| Phase | NA |
What NCT05050383 shows while recruiting
NCT05050383 is an interventional study that assigns participants to a tested intervention. The registered 241 participants enrollment target is mid-sized for trials with a published cap, above the 220-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target (10% higher).
The record links to 1 condition, with Obstructive Sleep Apnea appearing as the primary indexed condition, and to 2 interventions - of which Pharyngeal Manometry is the first listed.
NCT05050383 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05050383 about?
NCT05050383 is a clinical study titled "DISE: Phenotyping Obstruction Patterns". Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction. The investigators will ap...
What is the current status of trial NCT05050383?
This trial is currently recruiting. It is a NA study. The enrollment target is 241 participants. The study started on 2021-11-12. Estimated completion is 2027-09.
What conditions does trial NCT05050383 study?
This clinical trial studies the following conditions: Obstructive Sleep Apnea.
What interventions are being tested in trial NCT05050383?
The interventions under investigation include: Pharyngeal Manometry (OTHER), Submental Ultrasound (OTHER).
Who is sponsoring clinical trial NCT05050383?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05050383 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05050383's enrollment target sits among peer trials
241 31st of 155 higher than 125 of 155 other Obstructive Sleep Apnea trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obstructive Sleep Apnea trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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