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NCT05350332 · ClinicalTrials.gov registry record · NA
Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy
A NA study of Obstructive Sleep Apnea, sponsored by Emory University.
- Recruiting
- Registry status
- NA
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT05350332: Recruiting NA study of Obstructive Sleep Apnea, sponsored by Emory University.
NCT05350332 is a NA study of Obstructive Sleep Apnea that is actively recruiting participants, run by Emory University. The registered enrollment target is 200 participants, roughly in line with the 220-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05350332, a NA study of Obstructive Sleep Apnea, is actively recruiting participants, sponsored by Emory University.
- RECRUITING
- Registry status
- NA
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
Obstructive sleep apnea (OSA) is a disorder where a person has recurrent choking episodes during sleep. Surgery can treat OSA and drug induced sleep endoscopy (DISE) is a procedure that surgeons use to evaluate the throat while a person is sedated, mimicking sleep, to help determine if surgery might be effective. Lung volume can influence OSA severity but the relationship between lung function and throat collapse seen on DISE has not been well studied. This study aims to see if lung volume influences what is happening in the throat during DISE. Participants will be recruited from the sleep surgery clinic where they are being evaluated for surgery to treat their OSA. Participants will have a DISE that is performed as part of their routine surgical workup for treatment of OSA. Additionally, during the DISE, they will participate in one of two study groups. One group will have a negative pressure "turtle shell" ventilator placed over the participants chest during DISE to manipulate lung volumes to see if it can improve throat collapse. A second group will have electrodes placed over the neck to stimulate the phrenic nerve to contract the diaphragm to improve lung volumes to see if it can improve throat collapse. Both groups will also have a lung function test performed.The findings of this study will be important in improving pre-surgical evaluation of patients to better predict if surgery can help as well as potentially develop new surgical therapies for the treatment of OSA.
Primary Outcome
ERV is the volume of extra air that can be forcefully breathed out after exhaling normally. ERV is impacted by body size and altitude and the normal range for adults is about 0.7 to 1.1 liters (L). ERV is obtained as part of the pulmonary function test.
Conditions Studied
Interventions
- DEVICE Negative Pressure Ventilator
- DEVICE Pulmonary Function Testing (PFT)
- DEVICE Transcutaneous Phrenic Nerve Stimulation
Study Locations (1)
Georgia
- Emory University Hospital Midtown - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2022-06-30 |
| Est. Completion | 2026-06 |
| Phase | NA |
What NCT05350332 shows while recruiting
NCT05350332 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 220-participant average among 155 other Obstructive Sleep Apnea trials with a reported enrollment target.
The record links to 1 condition, with Obstructive Sleep Apnea appearing as the primary indexed condition, and to 3 interventions - of which Negative Pressure Ventilator is the first listed.
NCT05350332 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT05350332 about?
NCT05350332 is a clinical study titled "Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy". Obstructive sleep apnea (OSA) is a disorder where a person has recurrent choking episodes during sleep. Surgery can treat OSA and drug induced sleep endoscopy (DISE) is a procedure that surgeons use to evaluate the throat while a person is sedated, mimicking sleep, to help determine if surgery might...
What is the current status of trial NCT05350332?
This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2022-06-30. Estimated completion is 2026-06.
What conditions does trial NCT05350332 study?
This clinical trial studies the following conditions: Obstructive Sleep Apnea.
What interventions are being tested in trial NCT05350332?
The interventions under investigation include: Negative Pressure Ventilator (DEVICE), Pulmonary Function Testing (PFT) (DEVICE), Transcutaneous Phrenic Nerve Stimulation (DEVICE).
Who is sponsoring clinical trial NCT05350332?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05350332 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05350332's enrollment target sits among peer trials
200 39th of 155 higher than 113 of 155 other Obstructive Sleep Apnea trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obstructive Sleep Apnea trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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