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RECRUITING Phase 2

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

NCT06731907 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are investigating new treatments for untreated advanced non-small cell lung cancer (NSCLC), which is the most common form of lung cancer and lung cancer that has spread beyond surgical removal. Standard treatments include immunotherapy, such as pembrolizumab, and chemotherapy. This study aims to determine the effectiveness of adding other treatments, including the human epidermal growth factor receptor 3-directed antibody-drug conjugate (HER3-DXd) patritumab deruxtecan, to pembrolizumab, with or without chemotherapy. The primary goals are to assess safety and efficacy of the treatments.

Conditions Studied

Interventions

  • BIOLOGICAL Pembrolizumab
  • DRUG Carboplatin
  • DRUG Pemetrexed
  • DRUG Paclitaxel
  • DRUG Nab-paclitaxel

Study Locations (20)

Other

  • European Interbalkan Medical Center-Oncology Department ( Site 0205) — Thessaloniki
  • Országos Korányi Pulmonológiai Intézet ( Site 0060) — Budapest
  • Rambam Health Care Campus ( Site 0076) — Haifa
  • Shaare Zedek Medical Center ( Site 0075) — Jerusalem
  • Meir Medical Center ( Site 0071) — Kfar Saba
  • Rabin Medical Center ( Site 0074) — Petah Tikva
  • Sheba Medical Center ( Site 0070) — Ramat Gan
  • Sourasky Medical Center ( Site 0077) — Tel Aviv

Region M. de Santiago

  • Centro de Estudios Clínicos SAGA ( Site 0162) — Santiago
  • FALP ( Site 0161) — Santiago
  • Bradfordhill ( Site 0160) — Santiago

Kentucky

  • University of Kentucky ( Site 0019) — Lexington

Maryland

  • MedStar Franklin Square Medical Center ( Site 0033) — Baltimore

North Dakota

  • Sanford Fargo Medical Center ( Site 0039) — Fargo

Pennsylvania

  • Abramson Cancer Center ( Site 0010) — Philadelphia

South Dakota

  • Sanford Cancer Center ( Site 0038) — Sioux Falls

Attica

  • THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 0204) — Athens

Trial Details

FieldValue
Enrollment Target 90 participants
Start Date 2025-03-30
Est. Completion 2032-03-12
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06731907

The ClinicalTrials.gov registry entry for NCT06731907 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06731907 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Other, Region M. de Santiago, Kentucky. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06731907 about?

NCT06731907 is a clinical study titled "A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)". Researchers are investigating new treatments for untreated advanced non-small cell lung cancer (NSCLC), which is the most common form of lung cancer and lung cancer that has spread beyond surgical removal. Standard treatments include immunotherapy, such as pembrolizumab, and chemotherapy. This study...

What is the current status of trial NCT06731907?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 90 participants. The study started on 2025-03-30. Estimated completion is 2032-03-12.

What conditions does trial NCT06731907 study?

This clinical trial studies the following conditions: Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06731907?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Carboplatin (DRUG), Pemetrexed (DRUG), Paclitaxel (DRUG), Nab-paclitaxel (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06731907?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06731907 being conducted?

This trial has 20 study locations across Kentucky, Maryland, North Dakota, Pennsylvania, South Dakota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial