Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 203 recruiting now official registry

Non-Small Cell Lung Cancer clinical trials

203 of 450 indexed Non-Small Cell Lung Cancer trials are currently recruiting.

450 US clinical trials · 203 currently recruiting

Non-Small Cell Lung Cancer is the subject of 450 registered US clinical trials on ClinicalTrials.gov, 203 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 324 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 24 of these trials.

The research picture

Non-Small Cell Lung Cancer has 450 registered US clinical trials, 203 of them open to new participants right now, about 45% of the total.

203
recruiting participants now
45%
of trials open to enrollment
65
in Phase 3–4 (later-stage)
24
top sponsor: AstraZeneca
Phase 1201Phase 2123Phase 362Phase 43

Active & Recent Trials

450 total, page 4 of 9

RECRUITING Phase 2 66 participants

A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC

Teligene US

NCT06010329

RECRUITING NA 60 participants

Dyadic Yoga Program for Patients Undergoing Thoracic Radiotherapy and Their Family Caregivers: The Testing of a Mobile Application Delivery

M.D. Anderson Cancer Center

NCT06919874

RECRUITING Phase 2 60 participants

Using E-Nose Technology to Track Treatment Response in People With Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT07218601

RECRUITING Phase 1 60 participants

A Study of Tolododekin Alfa (ANK-101) in Combination With an Anti-PD-1/PD-L1 Antibody in Participants With Advanced Non-Small Cell Lung Cancer

Ankyra Therapeutics

NCT07027514

RECRUITING Phase 1 60 participants

Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer

Karen Reckamp, MD, MS

NCT05401110

RECRUITING Phase 1 60 participants

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

BioEclipse Therapeutics

NCT04282044

RECRUITING Phase 1 60 participants

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

AstraZeneca

NCT07115043

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Phase 2 60 participants

Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment

BioNTech SE

NCT06841055

RECRUITING Phase 2 59 participants

Carboplatin, Taxane And Ramucirumab for Patients With NSCLC After Pemetrexed or Pembrolizumab Maintenance

Abramson Cancer Center at Penn Medicine

NCT04332367

RECRUITING Phase 1 56 participants

A Study of Lorlatinib in Combination With Ramucirumab in People With Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT06007937

RECRUITING Phase 2 56 participants

Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung Cancer

University of California, Davis

NCT07250477

RECRUITING NA 54 participants

High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)

H. Lee Moffitt Cancer Center and Research Institute

NCT06337552

RECRUITING Phase 1 52 participants

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

Obsidian Therapeutics

NCT06060613

RECRUITING Phase 3 48 participants

Personalized Escalation of Consolidation Treatment Following Chemoradiotherapy and Immunotherapy in Stage III NSCLC in Stage III NSCLC

Maximilian Diehn

NCT04585490

RECRUITING Phase 1 46 participants

A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

AstraZeneca

NCT05877599

RECRUITING Phase 1 45 participants

Trabedersen (OT-101) With Pembrolizumab for Newly Diagnosed Advanced NSCLC and Positive PD-L1

University of Nebraska

NCT06579196

RECRUITING Phase 2 40 participants

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

Virginia Commonwealth University

NCT06731413

RECRUITING Phase 2 40 participants

A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer

Wayshine Biopharm

NCT06868485

RECRUITING Phase 1 40 participants

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Memgen

NCT05076760

RECRUITING Phase 1 40 participants

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 MAb, Administered Alone and in Combination with a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

Phanes Therapeutics

NCT05431270

RECRUITING NA 40 participants

Feasibility Testing of a Dyadic Exercise Program for Patients Undergoing Thoracic Radiotherapy and Their Family Caregivers

M.D. Anderson Cancer Center

NCT07234799

RECRUITING Phase 2 38 participants

Phase 2 Study of Fingolimod in Lung Cancers

Medical University of South Carolina

NCT06424067

RECRUITING Phase 2 37 participants

DRP-104 in Patients With NFE2L2/KEAP1-altered Non-Small Cell Lung Cancer

NYU Langone Health

NCT07249372

RECRUITING Phase 1 36 participants

Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer

Yale University

NCT04210492

RECRUITING Phase 2 34 participants

Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)

Medical College of Wisconsin

NCT06305715

RECRUITING Phase 1 33 participants

Phase 1 Trial of ZM008 as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Zumutor Biologics

NCT06451497

RECRUITING Phase 3 30 participants

Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

InSightec

NCT05317858

RECRUITING Phase 1 30 participants

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

University of Arizona

NCT06814496

RECRUITING Phase 1 30 participants

Tumor Treating Fields for Locally Advanced NSCLC

University of Utah

NCT06124118

RECRUITING Phase 2 30 participants

Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases

Ryan Gentzler, MD

NCT06248606

RECRUITING Phase 2 30 participants

ctDNA to Predict Response to Chemo-Immunotherapy and Detect Minimal Residual Disease in Non-Small Cell Lung Cancer

University of Miami

NCT06902272

RECRUITING Phase 2 29 participants

A Phase 2 Platform Study of Immunomodulatory Compounds in ICI-refractory Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT07133425

RECRUITING Phase 1 28 participants

Study of Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2

University of Rochester

NCT04297605

RECRUITING NA 26 participants

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

Memorial Sloan Kettering Cancer Center

NCT05837767

RECRUITING Phase 2 26 participants

Study of Healthy Donor FMT (hdFMT) and Pembrolizumab in Relapsed/Refractory (R/R) PD-L1 Positive NSCLC

Diwakar Davar

NCT05669846

RECRUITING Phase 2 25 participants

Repositioning Immunotherapy in VetArans With Lung Cancer

VA Office of Research and Development

NCT06275360

RECRUITING Phase 2 25 participants

A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

Memorial Sloan Kettering Cancer Center

NCT07323732

RECRUITING Phase 2 25 participants

BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab

Brown University

NCT04933903

RECRUITING Early Phase 1 24 participants

Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer

UNC Lineberger Comprehensive Cancer Center

NCT05620342

RECRUITING Phase 2 24 participants

DISCERN: Dual Versus Single ICB in PDL-1 Negative NSCLC

University of Alabama at Birmingham

NCT06364917

RECRUITING Phase 1 21 participants

Neoadjuvant Dupilumab and Cemiplimab in Patients With Early-stage Resectable NSCLC

Icahn School of Medicine at Mount Sinai

NCT06088771

RECRUITING NA 21 participants

Promoting Immunotherapy Efficacy With Low-Dose Liver RT

Jordan Kharofa

NCT07225036

RECRUITING Phase 1 20 participants

Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

University of California, Davis

NCT05452005

RECRUITING 20 participants

Cancer-related Fatigue During Maintenance Immunotherapy for Non-small Cell Lung Cancer (NSCLC): a Qualitative Study

Wake Forest University Health Sciences

NCT06567704

RECRUITING Phase 1 18 participants

A Study Evaluating Neoadjuvant Chemoimmunotherapy With Immunosensitizing Radiation for Borderline Resectable Non-Small Cell Lung Cancer

University of Maryland, Baltimore

NCT06800339

RECRUITING Phase 2 14 participants

A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT07428044

RECRUITING Phase 1 12 participants

KRAS-Targeted Vaccine With Nivolumab and Ipilimumab for Patients With NSCLC

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05254184

RECRUITING Early Phase 1 12 participants

Concurrent Chemotherapy Plus HFR Radiation Therapy in Inoperable NSCLC

State University of New York - Upstate Medical University

NCT02619448

RECRUITING Phase 1 12 participants

Liver SBRT in Combination With Immune Checkpoint Inhibition in Patients With Metastatic Non-small Cell Lung Cancer

VA Ann Arbor Healthcare System

NCT05430009

← Previous Page 4 of 9 Next →

Phase Distribution

PhaseTrial count
Phase 1 201
Phase 2 123
Phase 3 62
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Small Cell Lung Cancer Trial Landscape

450 indexed Non-Small Cell Lung Cancer studies · 203 recruiting (45%).

Phase mix: 65 late (III/IV) vs 324 early (I/II).

Top sponsor: AstraZeneca (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Small Cell Lung Cancer?

PlainTrial tracks 450 US clinical trials for Non-Small Cell Lung Cancer, of which 203 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.