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RECRUITING Phase 2

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

NCT04302025 · View on ClinicalTrials.gov ↗

Study Summary

This trial will evaluate the efficacy and safety of various therapies in participants with Stage IB, IIA, IIB, IIIA, or selected IIIB resectable and untreated NSCLC tumors that meet protocol-specified biomarker criteria.

Conditions Studied

Interventions

  • DRUG Vemurafenib
  • DRUG Alectinib
  • DRUG Entrectinib
  • DRUG Cobimetinib
  • DRUG Pralsetinib

Study Locations (20)

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • City of Hope - Orange County Lennar Foundation Cancer Center — Irvine
  • USC Norris Cancer Center — Los Angeles
  • Cedars-Sinai Medical Center — Los Angeles
  • University of California Los Angeles - Jonsson Comprehensive Cancer Center — Los Angeles
  • The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange — Orange
  • UC Davis Comprehensive Cancer Center — Sacramento
  • UCSF Helen Diller Family CCC — San Francisco

Illinois

  • Northwestern University — Chicago
  • Northwestern Medicine Cancer Center Kishwaukee — DeKalb
  • Northwestern Medicine Cancer Center Delnor — Geneva
  • Northwestern Medicine Cancer Center Warrenville — Warrenville

Massachusetts

  • Boston Medical Center — Boston
  • Dana-Farber Cancer Institute — Boston

Michigan

  • University of Michigan — Ann Arbor
  • Karmanos Cancer Institute - Farmington Hills/Weisberg Cancer Treatment Center — Farmington Hills

Colorado

  • University of Colorado - Anschutz Medical Campus (University of Colorado Health Sciences Center) — Aurora

Connecticut

  • Yale Cancer Center — New Haven

District of Columbia

  • MedStar Georgetown University Hospital (Lombardi Comprehensive Cancer Center) — Washington D.C.

Florida

  • Moffitt Cancer Center — Tampa

Trial Details

FieldValue
Enrollment Target 99 participants
Start Date 2020-11-06
Est. Completion 2030-05-30
Phase Phase 2

Sponsor

Genentech

206 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04302025

The ClinicalTrials.gov registry entry for NCT04302025 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 99 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Vemurafenib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04302025 reports 20 study locations spanning 8 distinct geographic areas — top geographies include California, Illinois, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04302025 about?

NCT04302025 is a clinical study titled "A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)". This trial will evaluate the efficacy and safety of various therapies in participants with Stage IB, IIA, IIB, IIIA, or selected IIIB resectable and untreated NSCLC tumors that meet protocol-specified biomarker criteria.

What is the current status of trial NCT04302025?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 99 participants. The study started on 2020-11-06. Estimated completion is 2030-05-30.

What conditions does trial NCT04302025 study?

This clinical trial studies the following conditions: Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04302025?

The interventions under investigation include: Vemurafenib (DRUG), Alectinib (DRUG), Entrectinib (DRUG), Cobimetinib (DRUG), Pralsetinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04302025?

This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04302025 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial