Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

NCT06465329 · View on ClinicalTrials.gov ↗

Study Summary

This study will enroll adult participants with early-stage (stage II-IIIB) non-small cell lung cancer for whom surgery is planned. The aim is to find out whether an investigational treatment (consisting of the immunotherapy drug cemiplimab plus chemotherapy plus a third drug) works better than cemiplimab plus chemotherapy without the additional drug. The study is also looking at several other research questions, including: * What are the side effects associated with the investigational treatments in comparison to the control treatment? * Do the investigational treatments or the control treatment have an effect on the type of surgery that is performed? * How much of the study drug(s) are in the blood at a given time? * Does the body make antibodies against the study drug(s) (which could make the drug(s) less effective or could lead to side effects)?

Conditions Studied

Interventions

  • DRUG Cemiplimab
  • DRUG Platinum-based chemotherapy
  • DRUG REGN7075

Study Locations (20)

Tennessee

  • University of Tennessee Medical Center — Knoxville
  • Sarah Cannon Research Institute (SCRI) Oncology Partners — Nashville
  • Tennessee Oncology — Nashville

Michigan

  • Karmanos Cancer Institute — Detroit
  • Detroit Clinical Research Center — Farmington Hills

New Jersey

  • Morristown Medical Center — Morristown
  • Rutgers Cancer Institute of New Jersey — New Brunswick

Oregon

  • Providence Portland Medical Center — Portland
  • University Of Nebraska Medical Center — Portland

Minas Gerais

  • Instituto Mario Penna — Belo Horizonte
  • Instituto Sul Mineiro De Oncologia LTDA — Pouso Alegre

California

  • University of California Irvine — Orange

Illinois

  • Orchard Healthcare Research Inc. — Skokie

Rhode Island

  • Lifespan Cancer Institute — Providence

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2024-11-18
Est. Completion 2030-05-02
Phase Phase 2

Sponsor

Regeneron Pharmaceuticals

290 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06465329

The ClinicalTrials.gov registry entry for NCT06465329 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Regeneron Pharmaceuticals, which has 290 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 3 interventions — of which Cemiplimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06465329 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Tennessee, Michigan, New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06465329 about?

NCT06465329 is a clinical study titled "A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)". This study will enroll adult participants with early-stage (stage II-IIIB) non-small cell lung cancer for whom surgery is planned. The aim is to find out whether an investigational treatment (consisting of the immunotherapy drug cemiplimab plus chemotherapy plus a third drug) works better than cemi...

What is the current status of trial NCT06465329?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 120 participants. The study started on 2024-11-18. Estimated completion is 2030-05-02.

What conditions does trial NCT06465329 study?

This clinical trial studies the following conditions: Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06465329?

The interventions under investigation include: Cemiplimab (DRUG), Platinum-based chemotherapy (DRUG), REGN7075 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06465329?

This trial is sponsored by Regeneron Pharmaceuticals, which has 290 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06465329 being conducted?

This trial has 20 study locations across California, Illinois, Michigan, New Jersey, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial