Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

NCT05742607 · View on ClinicalTrials.gov ↗

Study Summary

The study is intended to assess the safety and efficacy of neoadjuvant combination of IPH5201 and durvalumab in addition to standard chemotherapy and adjuvant combination of IPH5201 and durvalumab in untreated patients with resectable, early-stage (stage II to IIIA) non-small cell lung cancer (NSCLC).

Conditions Studied

Interventions

  • DRUG IPH5201 + durvalumab + standard chemotherapy

Study Locations (20)

Other

  • Angers University Hospital Center — Angers
  • University Hospital Center Caen — Caen
  • Hospital Calmette — Lille
  • CHU de Limoges — Limoges
  • Leon Berard Center — Lyon
  • Marseille University Hospital Center - North Hospital — Marseille
  • Rennes University Hospital Center - Hospital Pontchaillou — Rennes
  • Charles Nicolle Hospital — Rouen
  • Gustave Roussy — Villejuif
  • Henry Dunant Hospital Center — Athens
  • University General Hospital "Attikon" — Athens
  • University General Hospital of Ioannina — Ioannina
  • University General Hospital of Patras — Pátrai
  • Koranyi National Institute of Pulmonology, 14th Department of Pulmonology — Budapest

Florida

  • St. Anthony's Hospital - BayCare Health System — St. Petersburg
  • H. Lee Moffitt Cancer Center & Research Institute — Tampa

Illinois

  • University of Chicago Medical Center — Chicago

New York

  • Northwell Health Cancer Institute / Center for Novel Cancer Therapeutics — Lake Success

Texas

  • Millennium Research & Clinical Development — Houston

Wisconsin

  • UW Carbone Cancer Center - Cancer Connect — Madison

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2023-06-23
Est. Completion 2026-09
Phase Phase 2

Sponsor

Innate Pharma

63 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05742607

The ClinicalTrials.gov registry entry for NCT05742607 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Innate Pharma, which has 63 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non Small Cell Lung Cancer appearing as the primary indexed condition, and to 1 intervention — of which IPH5201 + durvalumab + standard chemotherapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05742607 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Other, Florida, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05742607 about?

NCT05742607 is a clinical study titled "IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)". The study is intended to assess the safety and efficacy of neoadjuvant combination of IPH5201 and durvalumab in addition to standard chemotherapy and adjuvant combination of IPH5201 and durvalumab in untreated patients with resectable, early-stage (stage II to IIIA) non-small cell lung cancer (NSCLC...

What is the current status of trial NCT05742607?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2023-06-23. Estimated completion is 2026-09.

What conditions does trial NCT05742607 study?

This clinical trial studies the following conditions: Non Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05742607?

The interventions under investigation include: IPH5201 + durvalumab + standard chemotherapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05742607?

This trial is sponsored by Innate Pharma, which has 63 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05742607 being conducted?

This trial has 20 study locations across Florida, Illinois, New York, Texas, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial