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ClinicalTrials.gov 120 recruiting now official registry

Multiple Sclerosis clinical trials

120 of 317 indexed Multiple Sclerosis trials are currently recruiting.

317 US clinical trials · 120 currently recruiting

Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.

The research picture

Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.

120
recruiting participants now
38%
of trials open to enrollment
41
in Phase 3–4 (later-stage)
13
top sponsor: Biogen
Phase 141Phase 233Phase 324Phase 417

Active & Recent Trials

317 total, page 4 of 7

ACTIVE NOT RECRUITING NA 52 participants

Lifestyle Physical Activity Intervention for Persons Newly Diagnosed With Multiple Sclerosis

University of Illinois at Chicago

NCT06355804

ACTIVE NOT RECRUITING NA 51 participants

Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis

University of Illinois at Chicago

NCT05930821

ACTIVE NOT RECRUITING NA 50 participants

A Study to Evaluate White Matter Hyperintensities in Migraine

Mayo Clinic

NCT05112289

ACTIVE NOT RECRUITING Phase 1 45 participants

MitoQ for Fatigue in Multiple Sclerosis (MS)

VA Office of Research and Development

NCT04267926

ACTIVE NOT RECRUITING 42 participants

Serum Neurofilament Light in Multiple Sclerosis

Dent Neuroscience Research Center

NCT06282081

ACTIVE NOT RECRUITING NA 40 participants

The Synergistic Effects of AIH and FES in Persons With MS

Shirley Ryan AbilityLab

NCT06413602

ACTIVE NOT RECRUITING Phase 4 40 participants

Cladribine Tablets After Treatment With Natalizumab (CLADRINA)

University of Texas Southwestern Medical Center

NCT04178005

ACTIVE NOT RECRUITING Phase 1 31 participants

WEBCAMS: Walking Exercise for Brain and Cognition in Adults With Multiple Sclerosis

Kessler Foundation

NCT05755061

ACTIVE NOT RECRUITING Early Phase 1 24 participants

Acute Effects of Walking Exercise on Brain Functioning in Multiple Sclerosis

Kessler Foundation

NCT06233370

ACTIVE NOT RECRUITING Phase 2 23 participants

A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis

Hoffmann-La Roche

NCT04075266

ACTIVE NOT RECRUITING Phase 1 20 participants

Safety of Bryostatin in Patients With MS

Robert Fox

NCT06190912

ACTIVE NOT RECRUITING NA 20 participants

Wearables for the Bladder: an In-home Treatment Feasibility Pilot Study

University of California, San Francisco

NCT05715268

ACTIVE NOT RECRUITING 14 participants

Investigating the Impact of Sex Hormones in Multiple Sclerosis

Milap Sandhu

NCT07081594

ACTIVE NOT RECRUITING Phase 2 12 participants

Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

National Institute of Neurological Disorders and Stroke (NINDS)

NCT04742400

ACTIVE NOT RECRUITING NA 11 participants

HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) - Multiple Sclerosis (MS)

Dartmouth-Hitchcock Medical Center

NCT06145737

ACTIVE NOT RECRUITING Phase 2 10 participants

"HB-adMSCs for the Treatment of Patients With Multiple Sclerosis"

Hope Biosciences Research Foundation

NCT06800404

ACTIVE NOT RECRUITING Early Phase 1 9 participants

Oral FMT (Fecal Microbial Transplant) in Subjects with Multiple Sclerosis

Griffin Hospital

NCT04096443

COMPLETED 4,361 participants

Risk Perception in Multiple Sclerosis

Novartis Pharmaceuticals

NCT05528666

COMPLETED 2,878 participants

Therapy Optimization in Multiple Sclerosis (MS)

Teva Neuroscience

NCT00819000

COMPLETED 2,182 participants

The MS-LINK™ Outcomes Study

EMD Serono Research & Development Institute

NCT04735406

COMPLETED Phase 3 1,133 participants

Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis

Actelion

NCT02425644

COMPLETED Phase 3 1,106 participants

Safety and Efficacy of Orally Administered Laquinimod Versus Placebo for Treatment of Relapsing Remitting Multiple Sclerosis (RRMS)

Teva Branded Pharmaceutical Products R&D

NCT00509145

COMPLETED Phase 4 1,001 participants

Using Patient Reported Outcomes (PROs) to Evaluate Teriflunomide Treatment in Relapsing Multiple Sclerosis (RMS) Patients

Sanofi

NCT01895335

COMPLETED 1,000 participants

Multi-center Database Registry to Study Thalamus Changes Using AI in MS

University at Buffalo

NCT03920995

COMPLETED 973 participants

The MURDOCK Study Community Registry and Biorepository Multiple Sclerosis Cohort

Duke University

NCT01723709

COMPLETED Phase 3 646 participants

Efficacy and Safety Study of Prolonged-Release Fampridine in Participants With Multiple Sclerosis

Biogen

NCT02219932

COMPLETED Phase 3 617 participants

Oral Cladribine in Early Multiple Sclerosis (MS)

EMD Serono Research & Development Institute

NCT00725985

COMPLETED 509 participants

Prospective, Open-label Tolerability and Safety Monitoring Study of Novantrone in a Selected Cohort of Multiple Sclerosis Patients

EMD Serono

NCT00262314

COMPLETED 414 participants

Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis

Novartis Pharmaceuticals

NCT02907281

COMPLETED Phase 2 407 participants

A Study of the Safety and Efficacy of ONO-4641 in Patients With Relapsing-Remitting Multiple Sclerosis

Ono Pharma USA

NCT01081782

COMPLETED 376 participants

Pregnancy Exposure Registry for Tysabri®

Biogen

NCT00472992

COMPLETED Phase 3 353 participants

Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis

RVL Pharmaceuticals

NCT01743651

COMPLETED Phase 3 323 participants

A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS

RVL Pharmaceuticals

NCT03319732

COMPLETED 300 participants

CogMS - A Real-world Study Into Cognitive Impairment in People With Multiple Sclerosis

icometrix

NCT05671055

COMPLETED Phase 2 284 participants

A 12 Week Randomized Open Label Parallel Group Multicenter Study to Evaluate Bioequivalence of 20 mg Subcutaneous Ofatumumab Injected by Pre-filled Syringe or Autoinjector in Adult RMS Patients

Novartis Pharmaceuticals

NCT03560739

COMPLETED NA 279 participants

Online Program to Reduce Depression in MS

Charite University, Berlin, Germany

NCT02740361

COMPLETED Phase 2 270 participants

Study of Subcutaneous Daclizumab in Patients With Active, Relapsing Forms of Multiple Sclerosis

PDL BioPharma

NCT00109161

COMPLETED 267 participants

Characterizing Upper Extremity Function in Individuals With Multiple Sclerosis

Mount Sinai Rehabilitation Hospital

NCT02398149

COMPLETED Phase 3 239 participants

Duloxetine for Multiple Sclerosis Pain

Eli Lilly and Company

NCT00755807

COMPLETED Phase 3 228 participants

Efficacy and Safety of Arbaclofen Placarbil in Subjects With Spasticity Due to Multiple Sclerosis

XenoPort

NCT01359566

COMPLETED 220 participants

An Observational Study on Teriflunomide-exposed Pregnancies

Sanofi

NCT03198351

COMPLETED 213 participants

Cognitive Testing for the Pain Quality Assessment Scale (PQAS)

University of Washington

NCT00715598

COMPLETED Phase 1 210 participants

Study to Compare GI Tolerability Following Oral Administration of Bafiertam™ or Tecfidera to Healthy Volunteers

Banner Life Sciences

NCT04022473

COMPLETED Phase 3 200 participants

Safety of Switching From Rituximab to Ocrelizumab in MS Patients

University of Colorado, Denver

NCT02980042

COMPLETED 196 participants

Longitudinal Analysis And Sample Collection To Evaluate PML Risk Host Markers for PML Risk Host Markers for PML Risk

Rocky Mountain MS Research Group

NCT02440126

COMPLETED Phase 3 185 participants

Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients

Novartis Pharmaceuticals

NCT03623243

COMPLETED NA 177 participants

Power Over Pain (POP) Study

University of Washington

NCT01800604

COMPLETED 176 participants

Telephone Interview of Patients That Participated in the the Pivotal Betaferon MS Trial.

Bayer

NCT01031459

COMPLETED 175 participants

Real World Effectiveness, Persistence, Tolerability, and Safety of Ofatumumab in Clinical Practice

Novartis Pharmaceuticals

NCT06737419

COMPLETED 157 participants

Comparison of Brain Atrophy Rates, Cognition, and Patient-Reported Outcomes in MS Patients Using Long-term Fingolimod and Glatiramer Acetate

University of Colorado, Denver

NCT02307877

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Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 33
Phase 3 24
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis Trial Landscape

317 indexed Multiple Sclerosis studies · 120 recruiting (38%).

Phase mix: 41 late (III/IV) vs 74 early (I/II).

Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis?

PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.