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Multiple Sclerosis clinical trials
120 of 317 indexed Multiple Sclerosis trials are currently recruiting.
317 US clinical trials · 120 currently recruiting
Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.
The research picture
Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.
- 120
- recruiting participants now
- 38%
- of trials open to enrollment
- 41
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Biogen
Active & Recent Trials
317 total, page 4 of 7
Lifestyle Physical Activity Intervention for Persons Newly Diagnosed With Multiple Sclerosis
University of Illinois at Chicago
NCT06355804
Exercise Training, Cognition, and Mobility in Older Adults With Multiple Sclerosis
University of Illinois at Chicago
NCT05930821
A Study to Evaluate White Matter Hyperintensities in Migraine
Mayo Clinic
NCT05112289
MitoQ for Fatigue in Multiple Sclerosis (MS)
VA Office of Research and Development
NCT04267926
Serum Neurofilament Light in Multiple Sclerosis
Dent Neuroscience Research Center
NCT06282081
The Synergistic Effects of AIH and FES in Persons With MS
Shirley Ryan AbilityLab
NCT06413602
Cladribine Tablets After Treatment With Natalizumab (CLADRINA)
University of Texas Southwestern Medical Center
NCT04178005
WEBCAMS: Walking Exercise for Brain and Cognition in Adults With Multiple Sclerosis
Kessler Foundation
NCT05755061
Acute Effects of Walking Exercise on Brain Functioning in Multiple Sclerosis
Kessler Foundation
NCT06233370
A Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis
Hoffmann-La Roche
NCT04075266
Safety of Bryostatin in Patients With MS
Robert Fox
NCT06190912
Wearables for the Bladder: an In-home Treatment Feasibility Pilot Study
University of California, San Francisco
NCT05715268
Investigating the Impact of Sex Hormones in Multiple Sclerosis
Milap Sandhu
NCT07081594
Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)
NCT04742400
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH) - Multiple Sclerosis (MS)
Dartmouth-Hitchcock Medical Center
NCT06145737
"HB-adMSCs for the Treatment of Patients With Multiple Sclerosis"
Hope Biosciences Research Foundation
NCT06800404
Oral FMT (Fecal Microbial Transplant) in Subjects with Multiple Sclerosis
Griffin Hospital
NCT04096443
Risk Perception in Multiple Sclerosis
Novartis Pharmaceuticals
NCT05528666
Therapy Optimization in Multiple Sclerosis (MS)
Teva Neuroscience
NCT00819000
The MS-LINK™ Outcomes Study
EMD Serono Research & Development Institute
NCT04735406
Oral Ponesimod Versus Teriflunomide In Relapsing MUltiple Sclerosis
Actelion
NCT02425644
Safety and Efficacy of Orally Administered Laquinimod Versus Placebo for Treatment of Relapsing Remitting Multiple Sclerosis (RRMS)
Teva Branded Pharmaceutical Products R&D
NCT00509145
Using Patient Reported Outcomes (PROs) to Evaluate Teriflunomide Treatment in Relapsing Multiple Sclerosis (RMS) Patients
Sanofi
NCT01895335
Multi-center Database Registry to Study Thalamus Changes Using AI in MS
University at Buffalo
NCT03920995
The MURDOCK Study Community Registry and Biorepository Multiple Sclerosis Cohort
Duke University
NCT01723709
Efficacy and Safety Study of Prolonged-Release Fampridine in Participants With Multiple Sclerosis
Biogen
NCT02219932
Oral Cladribine in Early Multiple Sclerosis (MS)
EMD Serono Research & Development Institute
NCT00725985
Prospective, Open-label Tolerability and Safety Monitoring Study of Novantrone in a Selected Cohort of Multiple Sclerosis Patients
EMD Serono
NCT00262314
Optical Coherence Tomography (OCT) Trial in Multiple Sclerosis
Novartis Pharmaceuticals
NCT02907281
A Study of the Safety and Efficacy of ONO-4641 in Patients With Relapsing-Remitting Multiple Sclerosis
Ono Pharma USA
NCT01081782
Pregnancy Exposure Registry for Tysabri®
Biogen
NCT00472992
Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis
RVL Pharmaceuticals
NCT01743651
A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS
RVL Pharmaceuticals
NCT03319732
CogMS - A Real-world Study Into Cognitive Impairment in People With Multiple Sclerosis
icometrix
NCT05671055
A 12 Week Randomized Open Label Parallel Group Multicenter Study to Evaluate Bioequivalence of 20 mg Subcutaneous Ofatumumab Injected by Pre-filled Syringe or Autoinjector in Adult RMS Patients
Novartis Pharmaceuticals
NCT03560739
Online Program to Reduce Depression in MS
Charite University, Berlin, Germany
NCT02740361
Study of Subcutaneous Daclizumab in Patients With Active, Relapsing Forms of Multiple Sclerosis
PDL BioPharma
NCT00109161
Characterizing Upper Extremity Function in Individuals With Multiple Sclerosis
Mount Sinai Rehabilitation Hospital
NCT02398149
Duloxetine for Multiple Sclerosis Pain
Eli Lilly and Company
NCT00755807
Efficacy and Safety of Arbaclofen Placarbil in Subjects With Spasticity Due to Multiple Sclerosis
XenoPort
NCT01359566
An Observational Study on Teriflunomide-exposed Pregnancies
Sanofi
NCT03198351
Cognitive Testing for the Pain Quality Assessment Scale (PQAS)
University of Washington
NCT00715598
Study to Compare GI Tolerability Following Oral Administration of Bafiertam™ or Tecfidera to Healthy Volunteers
Banner Life Sciences
NCT04022473
Safety of Switching From Rituximab to Ocrelizumab in MS Patients
University of Colorado, Denver
NCT02980042
Longitudinal Analysis And Sample Collection To Evaluate PML Risk Host Markers for PML Risk Host Markers for PML Risk
Rocky Mountain MS Research Group
NCT02440126
Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients
Novartis Pharmaceuticals
NCT03623243
Power Over Pain (POP) Study
University of Washington
NCT01800604
Telephone Interview of Patients That Participated in the the Pivotal Betaferon MS Trial.
Bayer
NCT01031459
Real World Effectiveness, Persistence, Tolerability, and Safety of Ofatumumab in Clinical Practice
Novartis Pharmaceuticals
NCT06737419
Comparison of Brain Atrophy Rates, Cognition, and Patient-Reported Outcomes in MS Patients Using Long-term Fingolimod and Glatiramer Acetate
University of Colorado, Denver
NCT02307877
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 33 |
| Phase 3 | 24 |
| Phase 4 | 17 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Multiple Sclerosis Trial Landscape
317 indexed Multiple Sclerosis studies · 120 recruiting (38%).
Phase mix: 41 late (III/IV) vs 74 early (I/II).
Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Multiple Sclerosis?
PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Multiple Sclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.