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NCT06413602 · ClinicalTrials.gov registry record · NA
The Synergistic Effects of AIH and FES in Persons With MS
A NA study of Multiple Sclerosis and Multiple Sclerosis (Relapsing Remitting), sponsored by Shirley Ryan AbilityLab.
- Active
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06413602: Active NA study of Multiple Sclerosis and Multiple Sclerosis (Relapsing Remitting), sponsored by Shirley Ryan AbilityLab.
NCT06413602 is a NA study of Multiple Sclerosis and Multiple Sclerosis (Relapsing Remitting) that is active but no longer recruiting, run by Shirley Ryan AbilityLab. The registered enrollment target is 40 participants, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06413602, a NA study of Multiple Sclerosis and Multiple Sclerosis (Relapsing Remitting), is active but no longer recruiting, sponsored by Shirley Ryan AbilityLab.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine how neuromuscular electrical stimulation (NMES), may synergistically enhance corticospinal excitability in people with relapsing form multiple sclerosis (MS). This is an important intermediate step to evaluate the potential of AIH + NMES as a plasticity-priming strategy for more efficacious interventions for persons with MS. This study will measure ankle torque generation and amplitude of motor evoked potentials (MEPs) using a repeated measures study design in order to better understand the effects of AIH combined with NMES, as compared to only receiving NMES, and only receiving AIH.
Primary Outcome
The MEPs will be elicited by Transcranial Magnetic Stimulation (TMS), a procedure that uses magnetic fields to stimulate nerve cells in the brain.
Conditions Studied
Interventions
- OTHER Acute Intermittent Hypoxia
- OTHER Neuromuscular Electrical Stimulation
Study Locations (1)
Illinois
- Shirley Ryan AbilityLab - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-11-01 |
| Est. Completion | 2027-08 |
| Phase | NA |
What the registry record for NCT06413602 still lists
NCT06413602 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (93% lower).
The record links to 3 conditions, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions - of which Acute Intermittent Hypoxia is the first listed.
NCT06413602 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06413602 about?
NCT06413602 is a clinical study titled "The Synergistic Effects of AIH and FES in Persons With MS". The purpose of this study is to examine how neuromuscular electrical stimulation (NMES), may synergistically enhance corticospinal excitability in people with relapsing form multiple sclerosis (MS). This is an important intermediate step to evaluate the potential of AIH + NMES as a plasticity-primin...
What is the current status of trial NCT06413602?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2024-11-01. Estimated completion is 2027-08.
What conditions does trial NCT06413602 study?
This clinical trial studies the following conditions: Multiple Sclerosis, Multiple Sclerosis (Relapsing Remitting), Multiple Sclerosis, Secondary Progressive.
What interventions are being tested in trial NCT06413602?
The interventions under investigation include: Acute Intermittent Hypoxia (OTHER), Neuromuscular Electrical Stimulation (OTHER).
Who is sponsoring clinical trial NCT06413602?
This trial is sponsored by Shirley Ryan AbilityLab, which has 138 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06413602 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Sclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06413602's enrollment target sits among peer trials
40 197th of 315 higher than 108 of 315 other Multiple Sclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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