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NCT06395662 · ClinicalTrials.gov registry record

Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.

A clinical trial of Multiple Sclerosis and Radiologically Isolated Syndrome, sponsored by Centre Hospitalier Universitaire de Nīmes.

Active
Registry status
320
Enrollment target
3
Study locations

NCT06395662: Active study of Multiple Sclerosis and Radiologically Isolated Syndrome, sponsored by Centre Hospitalier Universitaire de Nīmes.

NCT06395662 is a study of Multiple Sclerosis and Radiologically Isolated Syndrome that is active but no longer recruiting, run by Centre Hospitalier Universitaire de Nīmes. The registered enrollment target is 320 participants, below the 584-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (45% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06395662, a study of Multiple Sclerosis and Radiologically Isolated Syndrome, is active but no longer recruiting, sponsored by Centre Hospitalier Universitaire de Nīmes.

ACTIVE NOT RECRUITING
Registry status
320 participants
Enrollment target
3
Study locations

Study Summary

Radiologically isolated syndrome (RIS) often precedes Multiple Sclerosis (MS) but some patients have no symptoms. This study aims to use biological samples and magnetic resonance imaging (MRI) data from four large cohorts of patients with MS in the United States, Europe and France, to stratify the chances of RIS developing into MS. Identifying early biomarkers to predict greater disease severity would have a significant impact, not only on RIS but also on the entire clinical spectrum of multiple sclerosis.

Primary Outcome

Quantitative in g/mL, SIMOA (TM) in all cohorts: ARISE, TERIS, OFSEP and SFSEP. n=327

Conditions Studied

Multiple Sclerosis Radiologically Isolated Syndrome

Interventions

  • OTHER Observational

Study Locations (3)

Texas

  • University of Texas, Southwestern - Dallas

Alpes-Maritimes

  • COTE D'AZUR UNIVERSITY, URRIS-UR2CA. Hôpital Pasteur 2, 30, Voie Romaine - Nice

Rhône

  • INTERNATIONAL CENTER OF RESEARCH IN INFECTIOLOGY, LYON UNIVERSITY, INSERM U1111, CNRS UMR 5308, ENS, UCBL 46 Allée d'Italie - Lyon

Trial Details

FieldValue
Enrollment Target 320 participants
Start Date 2024-04-15
Est. Completion 2025-07
Centre Hospitalier Universitaire de Nīmes

1 total trials

What the registry record for NCT06395662 still lists

NCT06395662 is an observational study that tracks outcomes without assigning an intervention. The registered 320 participants enrollment target is mid-sized for trials with a published cap, below the 584-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (45% lower).

The record links to 2 conditions, with Multiple Sclerosis appearing as the primary indexed condition, and to 1 intervention - of which Observational is the first listed.

NCT06395662 reports a single indexed study location in Texas, Alpes-Maritimes, Rhône.

Frequently Asked Questions

What is clinical trial NCT06395662 about?

NCT06395662 is a clinical study titled "Stratification of Risks of Conversion of Radiologically Isolated Syndromes (RIS) by Identifying Biomarkers in Serum and Cerebrospinal Fluid.". Radiologically isolated syndrome (RIS) often precedes Multiple Sclerosis (MS) but some patients have no symptoms. This study aims to use biological samples and magnetic resonance imaging (MRI) data from four large cohorts of patients with MS in the United States, Europe and France, to stratify the c...

What is the current status of trial NCT06395662?

This trial is currently active not recruiting. The enrollment target is 320 participants. The study started on 2024-04-15. Estimated completion is 2025-07.

What conditions does trial NCT06395662 study?

This clinical trial studies the following conditions: Multiple Sclerosis, Radiologically Isolated Syndrome.

What interventions are being tested in trial NCT06395662?

The interventions under investigation include: Observational (OTHER).

Who is sponsoring clinical trial NCT06395662?

This trial is sponsored by Centre Hospitalier Universitaire de Nīmes, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06395662 being conducted?

This trial has 3 study locations across Texas, Alpes-Maritimes, Rhône. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Multiple Sclerosis

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06395662's enrollment target sits among peer trials

320 55th of 315 higher than 261 of 315 other Multiple Sclerosis trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Multiple Sclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT06395662, the US trial registry maintained by the National Library of Medicine. NCT06395662 (mid enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.