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NCT07224373 · ClinicalTrials.gov registry record · Phase 1

An Open-label Study of AZD0120 in Adults With Multiple Sclerosis

A Phase 1 study of Multiple Sclerosis, sponsored by AstraZeneca.

Recruiting
Registry status
Phase 1
Development phase
24
Enrollment target
13
Study locations

NCT07224373 is a Phase 1 study of Multiple Sclerosis that is actively recruiting participants, run by AstraZeneca. The registered enrollment target is 24 participants, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (96% lower). The trial reports 13 study locations across 10 states.

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The verdict

NCT07224373, a Phase 1 study of Multiple Sclerosis, is actively recruiting participants, sponsored by AstraZeneca.

RECRUITING
Registry status
Phase 1
Development phase
24 participants
Enrollment target
13
Study locations

Study Summary

This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with Multiple Sclerosis.

Conditions Studied

Multiple Sclerosis

Interventions

  • BIOLOGICAL AZD0120 - Regimen 1
  • BIOLOGICAL AZD0120 - Regimen 2

Study Locations (13)

Other

  • Research Site - Liverpool
  • Research Site - Melbourne
  • Research Site - Waratah

New York

  • Research Site - New York
  • Research Site - New York

Arizona

  • Research Site - Tucson

Colorado

  • Research Site - Aurora

District of Columbia

  • Research Site - Washington D.C.

Missouri

  • Research Site - St Louis

Ohio

  • Research Site - Cleveland

Washington

  • Research Site - Seattle

Trial Details

FieldValue
Enrollment Target 24 participants
Start Date 2025-12-09
Est. Completion 2028-12-07
Phase Phase 1

Sponsor

AstraZeneca

1,285 total trials

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What the Registry Record Tells You About NCT07224373

The ClinicalTrials.gov registry entry for NCT07224373 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 585-participant average among 315 other Multiple Sclerosis trials with a reported enrollment target (96% lower). The listed sponsor is AstraZeneca, which has 1,285 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Multiple Sclerosis appearing as the primary indexed condition, and to 2 interventions - of which AZD0120 - Regimen 1 is the first listed.

NCT07224373 reports 13 study locations spanning 10 distinct geographic areas - top geographies include Other, New York, Arizona.

Frequently Asked Questions

What is clinical trial NCT07224373 about?

NCT07224373 is a clinical study titled "An Open-label Study of AZD0120 in Adults With Multiple Sclerosis". This trial is a Phase 1b, open-label, multi-center, clinical study of AZD0120, a BCMA/CD19 dual targeting CAR+ T-cell therapy, to evaluate the safety and tolerability in adult participants with Multiple Sclerosis.

What is the current status of trial NCT07224373?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2025-12-09. Estimated completion is 2028-12-07.

What conditions does trial NCT07224373 study?

This clinical trial studies the following conditions: Multiple Sclerosis.

What interventions are being tested in trial NCT07224373?

The interventions under investigation include: AZD0120 - Regimen 1 (BIOLOGICAL), AZD0120 - Regimen 2 (BIOLOGICAL).

Who is sponsoring clinical trial NCT07224373?

This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07224373 being conducted?

This trial has 13 study locations across Arizona, Colorado, District of Columbia, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.